DAPSONE

PRODUCT IDENTIFICATION
CAS NO. 80-08-0

DAPSONE
EINECS NO. 201-248-4
FORMULA (H2NC6H4)2SO2
MOL WT. 248.30

H.S. CODE

  

TOXICITY

 Oral rat LD50: 1000mg/kg
SMILES

 
SYNONYMS 4,4'-Sulfonylbisbenzamine; DDS;
1,1'-Sulfonylbis(4-aminobenzene); 4,4'-Diaminodiphenyl sulfone; 4,4'-Diaminophenyl sulfone; 4,4-Sulfonyldianiline; 4,4'-Sulfonylbisbenzenamine; 4-Aminophenyl sulfone; Sulfonyldianiline;

CLASSIFICATION

  

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white crystalline powder
MELTING POINT 175 - 180 C
BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER Insoluble
pH  
VAPOR DENSITY

8.3
AUTOIGNITION

 
NFPA RATINGS Health: 1; Flammability: 0; Reactivity: 0

REFRACTIVE INDEX

  
FLASH POINT

 
STABILITY

Stable under ordinary conditions

APPLICATIONS
Sulfoxide (R2SO) is any of various organic sulfur compounds having the group -SO (sulfinyl group) whereas sulfone (RSOOR) with the group -SO2 (sulfonyl group). They are derived from oxidation of sulfides. They are widely used as solvent of both extraction and reaction as well as intermediates for the synthesis of textile chemicals and pharmaceuticals and agrochemicals.

Organosulfone compounds are widely used in refineries, steamcrackers, aromatic extraction and petrochemical manufacturing as they acts as;

  • Hydrotreating catalysts
  • Initial catalyst improvers
  • Sulfur sources
  • Catalyst presulfiding
  • Natural gas sulfur recovery

Organosulfone compounds are also used in;

  • Organic synthesis as organosulfur sources into target organic molecules for the manufacture of pharmaceuticals, adhesives biocides and agricultural products.
  • Polymer production
  • Lubricant and fuel additives for extreme pressure functionality
  • Extraction and reaction solvent
  • Metal treatment
  • Fungicide
Dapsone (4,4'-sulfonylbisbenzenamine) is a parent compound in preparing sulfonamide antibacterial agents such as acedapsone, acetosulfone, glucosulfone, sulfoxone and solapsone. Dapsone and its derivatives have bacteriostatic activity against a broad spectrum of gram-negative and gram-positive organisms. Dapsone is a primary treatment for Dermatitis herpetiformis and in the treatment of leprosy (Mycobacterium leprae infections) leads to apparent improvementas. It is used in the prophylaxis of falciparum malaria. It is a white crystalline powder; melting point 175 - 180C; insoluble in water and vegetable oils.

Dapsone is also widely used in polymer industry as a cross linkage agent in manufacturing polysulfone amide engineering plastics. Sulfone-containing engineering plastics are thermally stable and have high resistance property to acids and alkalis.
SALES SPECIFICATION

APPEARANCE

 white crystalline powder

PURITY

99.5% min

LOSS ON DRYING

0.5% max

MELTING POINT

175 - 180 C
TRANSPORTATION
PACKING
25kgs in fiber drum
HAZARD CLASS  
UN NO.  
OTHER INFORMATION
Hazard Symbols: XN, Risk Phrases: 22, Safety Phrases: 22-28A-37-45