PRODUCT IDENTIFICATION

H.S. CODE

TOXICITY

CLASSIFICATION

Antagonist, Anti-ulcer agent, Gastrointestinal agent, Histamine agent, Histamine H2 antagonist, Guanidine, Thiazole, Thioether, Sulfonamide

EXTRA NOTES

PHYSICAL AND CHEMICAL PROPERTIES

REFRACTIVE INDEX

Stable under ordinary conditions.

EXTERNAL LINKS & GENERAL DESCRIPTION

Wikipedia Linking

Google Scholar Search

Drug Information Portal (U.S. National Library of Medicine) - Famotidine

http://www.drugbank.ca/
Mechanism of action: Famotidine binds competitively to H2-receptors located on the basolateral membrane of the parietal cell, blocking histamine affects. This competitive inhibition results in reduced basal and nocturnal gastric acid secretion and a reduction in gastric volume, acidity, and amount of gastric acid released in response to stimuli including food, caffeine, insulin, betazole, or pentagastrin.

http://www.egeneralmedical.com/
The active ingredient in Pepcid is a histamine H₂-receptor antagonist. Famotidine is N'-(aminosulfonyl)-3-[[[2-[(diaminomethylene)amino]-4-thiazolyl]methyl]thio] propanimidamide. The empirical formula of famotidine is C₈H₁₅N₇O₂S₃ and its molecular weight is 337.43. Famotidine is a white to pale yellow crystalline compound that is freely soluble in glacial acetic acid, slightly soluble in methanol, very slightly soluble in water, and practically insoluble in ethanol. Each tablet for oral administration contains either 20 mg or 40 mg of famotidine. Inactive Ingredients: Hydroxypropyl cellulose, hydroxypropyl methylcellulose, iron oxides, magnesium stearate, microcrystalline cellulose, starch, talc, titanium dioxide. Each Pepcid RPD orally disintegrating tablet for oral administration contains either 20 mg or 40 mg of famotidine and the following inactive ingredients: aspartame, mint flavor, gelatin, mannitol, red ferric oxide, and xanthan gum. Each 5 ml of the oral suspension when prepared as directed contains 40 mg of famotidine and the following inactive ingredients: citric acid, flavors, microcrystalline cellulose and carboxymethylcellulose sodium, sucrose and xanthan gum. Added as preservatives are sodium benzoate 0.1%, sodium methylparaben 0.1%, and sodium propylparaben 0.02%. Each ml of the solution for intravenous injection contains 10 mg of famotidine. Inactive Ingredients: L-aspartic acid 4 mg, mannitol 20 mg, and Water for Injection q.s. 1 ml. The multidose injection also contains benzyl alcohol 0.9% added as preservative.

Local:
Famotidine is a histamine H₂-receptor antagonist (also called H₂-blocker) which decreases the amount of acid produced by the stomach and is used to treat gastric and duodenal ulcers by blocking the H2 subtype of histamine receptors. Examples of H2-blockers are cimetidine, famotidine and nizatidine. The chemical designation of famotidine is N'-(aminosulfonyl)-3-[[[2- [(diaminomethylene) amino]- 4-thiazolyl] methyl]thio] propanimidamide. It is a white to pale yellow crystalline compound; very slightly soluble in water, insoluble in alcohol, chloroform (slightly soluble in methanol), freely soluble in glacial acetic and DMF; melting point 161 - 163 C. Examples of H₂-receptor antagonist include

APPEARANCE

IDENTIFICATION

passes test A,B

98.0.% - 101.0%

RELATED SUBSTANCE

Complies

RESIDUE ON IGNITION

0.1% max

VOLATILES

Complies

HEAVY METALS

10ppm max