GABAPENTIN

PRODUCT IDENTIFICATION
CAS NO. 60142-96-3

GABAPENTIN

EINECS NO. 262-076-3
FORMULA C9H17NO2
MOL WT. 171.24

H.S. CODE

 2922.49.4050

TOXICITY

 Oral Rat LD50: > 8gm/kg
SYNONYMS 1-(Aminomethyl)cyclohexaneacetic acid; Gabapentino;
Aclonium; Gabapentine; Gabapentino; Gabapentinum; Neuontin; Neurontin;
SMILES C1(CC(O)=O)(CCCCC1)CN

CLASSIFICATION

Analgesic, Anti-Dyskinesia agent, Anti-anxiety agent, Anticonvulsant, Antimanic agent, Antiparkinson agent, Calcium Channel Blocker, Cardiovascular Agent, Excitatory Amino Acid Antagonist, Membrane Transport Modulator, Psychotropic, Tranquilizing agent

EXTRA NOTES

 Can be viewed as a cyclohexane-GABA; an oral medication for add-on therapy in the treatment of partial seizures in adult epilepsy; inhibits dopamine release from rabbit caudate nucleus.

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white to off-white crystalline powder
MELTING POINT  
BOILING POINT

 

SPECIFIC GRAVITY

 

SOLUBILITY IN WATER 4490 mg/l
pH 6.5 - 7.5
VAPOR DENSITY

 

AUTOIGNITION

 

VAPOR PRESSURE 2.94E-10 (mmHg at 25 C)
HENRY LAW CONSTANT 1.81E-10 (atm-m3/mole at 25 C)
OH RATE CONSTANT 4.01E-11 (cm3/molecule-sec at 25 C Atmospheric)

NFPA RATINGS

Health hazard: 2, Fire: 0, Reactivity Hazard: 0

REFRACTIVE INDEX

 

FLASH POINT

 

STABILITY

Stable under ordinary conditions.

EXTERNAL LINKS & GENERAL DESCRIPTION

Wikipedia Linking

http://www.cancer.org/
Gabapentin is used as a non-opioid pain reliever. It belongs to a general class of drugs called anticonvulsants (anti-seizure drugs). It is given along with pain medicines to help control neuropathic pain (numbness, tingling, burning, shooting, or electric-shock-like pain). It is also used to help prevent seizures and for other purposes.

Google Scholar Search

http://medlibrary.org/
Gabapentin is structurally related to the neurotransmitter GABA (gamma-aminobutyric acid) but it does not modify GABAA or GABAB radioligand binding, it is not converted metabolically into GABA or a GABA agonist, and it is not an inhibitor of GABA uptake or degradation. Gabapentin was tested in radioligand binding assays at concentrations up to 100 µM and did not exhibit affinity for a number of other common receptor sites, including benzodiazepine, glutamate, N-methyl-D-aspartate (NMDA), quisqualate, kainate, strychnine-insensitive or strychnine-sensitive glycine, alpha 1, alpha 2, or beta adrenergic, adenosine A1 or A2, cholinergic muscarinic or nicotinic, dopamine D1 or D2, histamine H1, serotonin S1 or S2, opiate mu, delta or kappa, cannabinoid 1, voltage-sensitive calcium channel sites labeled with nitrendipine or diltiazem, or at voltage-sensitive sodium channel sites labeled with batrachotoxinin A 20-alpha-benzoate. Furthermore, gabapentin did not alter the cellular uptake of dopamine, noradrenaline, or serotonin.

Drug Information Portal (U.S. National Library of Medicine) - GABAPENTIN

Local: Gabapentin is used in adjunctive therapy to treat partial seizures. It is chemically related to gamma--aminobutyric acid (GABA) which is the principal inhibitory neurotransmitter in the brain. Gabapentin is an anti-epileptic agent (anticonvulsant). Chemically, gabapentin is described as 1-(Aminomethyl)cyclohexaneacetic acid; white crystalline powder. Other structurally GABA class anticonvulsants include Pregabalin [3-isobutyl GABA, CAS RN: 148553-50-8], Vigabatrin [gamma-Vinyl GABA, CAS RN: 60643-86-9]

APIs for Treatments of Alcohol Dependence

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Fluoxetine

 54910-89-3

Nalmefene

 55096-26-9
Fluoxetine hydrochloride 56296-78-7
Gabapentin 60142-96-3
Apraclonidine 66711-21-5
Apraclonidine hydrochloride 73218-79-8
Acamprosate calcium 77337-73-6
Acamprosate 77337-76-9

Topiramate

97240-79-4
Ondansetron hydrochloride dihydrate  99614-01-4
Ondansetron 99614-02-5
Ondansetron hydrochloride 103639-04-9
SALES SPECIFICATION

APPEARANCE

 white to off-white crystalline powder

IDENTIFICATION

complies

ASSAY

 99.0 - 101.0%
RESIDUE ON IGNITION

0.1% max
WATER

0.5% max

HEAVY METALS

10ppm max
TRANSPORTATION
PACKING
 
HAZARD CLASS Not regulated
UN NO.  
SAFETY INFORMATION

GHS

 
SIGNAL WORD Danger

PICTOGRAMS

HAZARD STATEMENTS

H315 Causes skin irritation
H319 Causes serious eye irritation
H335 May cause respiratory irritation
H360 May damage fertility or the unborn child.

PRECAUTIONARY STATEMENTS

P201 Obtain special instructions before use
P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing
P308 + P313 IF exposed or concerned: Get medical advice/ attention
EC DIRECTIVES

 
HAZARD CODES

 

RISK PHRASES

 

SAFETY PHRASES

 

PRICE INFORMATION