GLIMEPIRIDE

PRODUCT IDENTIFICATION
CAS NO. 93479-97-1

GLIMEPIRIDE

EINECS NO.  
FORMULA C24H34N4O5S
MOL WT. 490.62

H.S. CODE

  

TOXICITY

  
SMILES

 
SYNONYMS Amaryl; Glimepirid; Glimepirida; Glimepiridum;

1-[[p-[2-(3-ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido) ethyl]phenyl] sulfonyl]-3-(trans-4- methyl cyclohexyl) Urea; trans-2,5-Dihydro-3-ethyl-4-methyl-N-(2-(4-(((((4-methylcyclohexyl)amino) carbonyl)amino)sulfonyl)phenyl)ethyl)-2-oxo-1H-pyrrole-1-carboxamide; Endial;

CLASSIFICATION

 HYPOGLYCEMIC AGENTS / IMMUNOSUPPRESSIVE AGENTS /

PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE white to yellowish crystalline powder
MELTING POINT 188 - 192 C
BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER  
pH  
VAPOR DENSITY

 

AUTOIGNITION

 

NFPA RATINGS

  

REFRACTIVE INDEX

  
FLASH POINT

 

STABILITY Stable under ordinary conditions.

GENERAL DESCRIPTION & APPLICATIONS
Sulfonylureas: a class of oral hypoglycaemic agents that exert hypoglycemic activity by stimulating the pancreas to secrete more insulin, active in type II diabetes only. Sulfonylureas have a phenyl ring nucleus with two branched chains in chemical structure. They can can induce hypoglycemia which  is potential life threatening side effect in case of over-dose.

Glimepiride, belongs to the class of sulfonylurea, is an oral blood-glucose-lowering drug actong for medium- to-long period. It is a white to yellowish crystalline powder with odorless; melting point 205 -207 C. The chemical designation is 1-[[p-[2-(3-ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido) ethyl]phenyl] sulfonyl]-3-(trans-4-methylcyclohexyl) Urea.

Some classes of drugs of anti-diabete include:

  • Sulfonylureas
    • Chlorpropamide (CAS#: 94-20-2)
    • Tolbutamide (CAS#: 64-77-7)
    • Tolazamide (CAS#: 1156-19-0)
    • Glipizide (CAS#: 29094-61-9)
    • Glyburide (CAS#: 10238-21-8)
    • Gliclazide (CAS#: 21187-98-4)
    • Glibenclamide (CAS#: 10238-21-8)
    • Glimepiride (CAS#: 93479-97-1)
    • Gliquidone (CAS#: 33342-05-1)
  • Meglitinide analogues
    • Repaglinide (CAS#: 135062-02-1)
    • Nateglinide (CAS#: 105816-04-4)
    • Meglitinide (CAS#: 54870-28-9)
    • Mitiglinide (CAS#: 145375-43-5)
    • Mitiglinide Calcium (CAS #: 145525-41-3)
  • Biguanide
    • Metformin (CAS#: 657-24-9)
    • Phenformin (CAS#: 114-86-3)
  • Thiazolidinediones (Glitazones)
    • Rosiglitazone (CAS#: 155141-29-0)
    • Pioglitazone (CAS#: 111025-46-8)
  • Alpha-glucosidase Inhibitors
    • Acarbose (CAS#: 56180-94-0)
    • Miglitol (CAS#: 72432-03-2)
  • Dipeptidylpeptidase IV inhibitor
    • Saxagliptin (CAS#: 361442-04-8)
    • Sitagliptin (CAS#: 790712-60-6)
    • Vildagliptin (CAS#: 274901-16-5)
SALES SPECIFICATION

APPEARANCE

 white to yellowish crystalline powder

ASSAY (HPLC)

 99.0% min

MELTING POINT

205 - 207 C

LOSS ON DRYING

0.5% max

TOTAL IMPURITY

1.0% max
HEAVY METALS

20ppm max
TRANSPORTATION
PACKING

 

HAZARD CLASS  
UN NO.  
OTHER INFORMATION