| CAS
NO. |
127-07-1 |
|
| EINECS
NO. |
204-821-7 |
| FORMULA |
HONHCONH2 |
| MOL
WT. |
76.06 |
|
H.S.
CODE
|
|
|
TOXICITY
|
Oral
rat LD50: 5760 mg/kg |
| SYNONYMS |
Hydrea;
Hydroxycarbamide; Hydroxycarbamine; 羟基脲;
|
| Hydura;
Hydurea; N-Carbamoylhydroxylamine; N-Hydroxyurea;
Oxyurea; N-(aminocarbonyl)hydroxylamine;
1-hydroxyurea; Hidroxicarbamida; |
| PRICE |
|
|
CLASSIFICATION
|
|
|
PHYSICAL
AND CHEMICAL PROPERTIES
|
| PHYSICAL
STATE |
white
to light yellow powder |
| MELTING
POINT |
135
- 140 C |
| BOILING
POINT |
|
| SPECIFIC
GRAVITY |
|
| SOLUBILITY
IN WATER |
freely
soluble (decomposes in the presence of moisture) |
| pH |
|
| VAPOR
DENSITY |
|
|
AUTOIGNITION
|
|
|
NFPA
RATINGS
|
|
|
REFRACTIVE
INDEX
|
|
| FLASH
POINT |
|
| STABILITY |
Stable
under ordinary conditions (hygroscopic) |
|
APPLICATIONS
|
|
Hydroxyurea is an antimetabolite to be used as an antineoplastic agent. It acts
as an inhibitor of ribonucleoside reductase, an enzyme involved in the
conversion of ribonucleotides to deoxyribonucleotides, an essential process in
DNA synthesis. Hydroxyurea is also used as an immunosuppressant by decreasing
the amount of intracellular deoxynucleotides, essential in viral replication. It
is believed that it inhibits human immunodeficiency virus 1 (HIV-1). It is used
to treat some types of leukaemia and carcinoma of the head and neck, ovary, and
cervix, malignant melanoma, and blood disease polycythemia vera. Antimetabolite is a chemical compound that closely resembles a metabolite in
molecular structure, but can interfering with the normal reactions of the
essential metabolite. It prevent the cell from the utilization of the genuine
substance necessary to normal biochemical reactions. Chemically modified
nucleotides substituted or attached by special chemical groups or elements are
studied and used to inactivate the normal biological operation in the living
organism and the function of important enzymes. Aminopterin (4-aminofolic acid)
and methotrexate (mthylaminopterin) are antagonists of folic acid, and used in
the treatment of some neoplastic diseases. Azathioprine and mercaptopurine are
purine antagonists. 5-Fluorouracil and fluorodeoxyuridine are examples of
pyrimidine antagonists; used as an antineoplastic and as a component of
chemotherapy regimens. DNA synthesis inhibitors for antitumor effects
include:
|
| SALES
SPECIFICATION |
|
APPEARANCE
|
white
to light yellow powder |
|
PURITY
|
98.0%
min
|
| MELTING
POINT |
135
- 140 C |
| TRANSPORTATION |
| PACKING |
|
| HAZARD
CLASS |
|
| UN
NO. |
1851 |
| OTHER
INFORMATION |
| Hazard Symbols: XN, Risk Phrases: 22/33/36/37/38,
Safety Phrases: 24/25 |