ISONIAZID (PYRIDINE-4-CARBOHYDRAZIDE)

ISONIAZID
PRODUCT IDENTIFICATION
CAS NO.	54-85-3
EINECS NO.	200-214-6
FORMULA	C₆H₇N₃O
MOL WT.	137.14
H.S. CODE
TOXICITY
SYNONYMS	Pyridine-4-carbohydrazide;
4-Pyridinecarboxylic acid hydrazide; Isonicotinic acid hydrazide; Isonicotinoyl hydrazide;
SMILES
CLASSIFICATION
PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE	white crystalline powder
MELTING POINT	170 - 173 C
BOILING POINT
SPECIFIC GRAVITY
SOLUBILITY IN WATER	soluble
pH
VAPOR DENSITY
AUTOIGNITION
NFPA RATINGS	`Health: 1; Flammability: 0; Reactivity: 0`
REFRACTIVE INDEX
FLASH POINT
STABILITY	stable under ordinary conditions.
APPLICATIONS
Isonicotinic acid, an isomer of nicotinic acid, is a six-membered ring structure compound composed of five carbon atoms and a nitrogen which replace one carbon-hydrogen unit in the benzene ring, plus a carboxyl side chain at 4-position (nicotinic acid has a carboxyl side chain at 3-position). Isonicotinic acid is chiefly used in antituberculosis drugs especially Isoniazid (isonicotinic acid hydrazide), the most effective one. Isonicotinic acid and its derivatives are used in manufacturing pharmaceuticals and agrochemicals. Niacin acts to reduce plasma cholesterol, as a vasodilator and to treat pellagra. Niacin is used for the prophylaxis. Their derivatives are used for these effects. Isoniazid is an antibacterial by inhibiting the mycolic acid cell wall synthesis. It is used as a tuberculostatic. chemically, it is known as isonicotinyl hydrazine or isonicotinic acid hydrazide. It is a white crystalline powder; melting point 170 C; soluble in water, sparingly soluble in alcohol, and slightly soluble in chloroform and ether.
SALES SPECIFICATION ( USP25)
APPEARANCE	white crystalline powder
ASSAY	98.0 - 102.0%
IDENTIFICATION	pass
RESIDUE ON IGNITION	0.2% max
HEAVY METALS	20ppm max
pH	6,5 - 7.5
MELTING POINT	170 - 173 C
ORGANIC IMPURITY	0.5% max
TRANSPORTATION
PACKING
HAZARD CLASS
UN NO.
OTHER INFORMATION
`Hazard Symbols: XN, Risk Phrases: 22/36/37/38, Safety Phrases: 24/25`