|
|
|
| LIDOCAINE | ||
|
PRODUCT IDENTIFICATION |
||
| CAS NO. | 137-58-6 (Base), 73-78-9 (HCl) |
|
| EINECS NO. |
205-302-8 |
|
| FORMULA |
(CH3)2C6H3NHCOCH2N(C2H5)2 |
|
| MOL WT. | 234.34 | |
|
H.S. CODE |
||
| SMILES |
|
|
|
TOXICITY |
||
| SYNONYMS | 2-(Diethylamino)-2',6'-Acetoxylidide; Lida-Mantle; Xilina; | |
| 2-(diethylamino)-N-(2,6-dimethylphenyl)-Acetamide; Xyloneural; Cappicaine; alpha-(Diethylamino)-2,6-acetoxylidide; Duncaine; Gravocain; Isicaina; Isicaine; Leostesin; Lignocaine; Maricaine; Xycaine; Xylestesin; Xylocain; Xylocaine; Xylocitin; Xylotox; 2-(Diethylamino)-2',6'-acetoxylidide; Diethylaminoaceto-2,6-xylidide; alpha-Diethylamino-2,6-dimethylacetanilide; alpha-Diethylaminoaceto-2,6-xylidide; Xllina; | ||
|
CLASSIFICATION |
||
|
GENERAL DESCRIPTION OF LOCAL ANESTHETIC |
||
| Local anesthetic is a substance that causes loss of sensation only to the area to which it is applied without affecting consciousness. Most local anesthetics structures have amino-ester or an amino-amide group which are linked to hydrophilic (secondary or tertiary amine) and to hydrophobic group (aromatics) on the other sid. The ester can be hydrolysed in plasma by the enzyme pseudocholinesterase into para-aminobenzoic acid. Amide is stable for longer acting and more systemic distribution. Ester types include Procaine (Novocain), Chloroprocaine (Nesacaine), Cocaine, Tetracaine (Pontocaine), Benzocaine, Tetracaine. Amide types include Lidocaine (Xylocaine), Mepivacaine(Carbocaine), Prilocaine (Citanest), Bupivacaine (Marcaine), Etidocaine (Duranest). Tricaine is used in aquaculture, fishery and veterinary. | ||
|
PHYSICAL AND CHEMICAL PROPERTIES |
||
| PHYSICAL STATE | White crystalline powder | |
| MELTING POINT |
66 - 69 C |
|
| BOILING POINT | ||
| SPECIFIC GRAVITY | ||
| SOLUBILITY IN WATER | ||
| pH | ||
| VAPOR DENSITY |
|
|
| AUTOIGNITION |
|
|
| NFPA RATINGS | ||
|
REFRACTIVE INDEX |
||
| FLASH POINT |
|
|
| STABILITY |
Stable under ordinary conditions. |
|
|
APPLICATIONS |
||
| Lidocaine, the first amide type, is used chiefly as a local anesthetic and antiarrhythmic agent in the form of its hydrochloride. | ||
| SALES SPECIFICATION | ||
| BP/USP | ||
|
APPEARANCE |
White crystalline powder | |
|
ASSAY |
98.5 - 101.0% |
|
| MELTING POINT |
66 - 69 C |
|
|
LOSS ON DRYING |
0.3% max |
|
|
RESIDUE ON IGNITION |
0.1% max |
|
|
HEAVY METALS |
20ppm max |
|
| TRANSPORTATION | ||
| PACKING |
25kgs
in fiber drum
|
|
| HAZARD CLASS | ||
| UN NO. | ||
| OTHER INFORMATION | ||
| Hazard Symbols: , Risk Phrases: 36/37/38, Safety Phrases: 22-26-36 | ||
|
|
|
