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| LORATADINE | ||
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PRODUCT IDENTIFICATION |
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| CAS NO. | 79794-75-5 |
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| EINECS NO. | ||
| FORMULA | C22H23ClN2O2 | |
| MOL WT. | 382.89 | |
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H.S. CODE |
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TOXICITY |
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| SYNONYMS | ||
| Claratyne; Claritin; 4-(8-chloro-5,6-dihydro-11H-benzo[5,6] cyclohepta[1,2-b]pyridin- 11-ylidene)-1-piperidinecarboxylate, ethyl ester; | ||
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CLASSIFICATION |
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PHYSICAL AND CHEMICAL PROPERTIES |
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| PHYSICAL STATE | White powder | |
| MELTING POINT | 132 - 135 C | |
| BOILING POINT | ||
| SPECIFIC GRAVITY | ||
| SOLUBILITY IN WATER | Insoluble | |
| pH | ||
| VAPOR DENSITY |
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AUTOIGNITION |
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NFPA RATINGS |
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REFRACTIVE INDEX |
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| FLASH POINT |
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| STABILITY | Stable under ordinary conditions. | |
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APPLICATIONS |
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| Antihistamine is a group of drugs characterized by the ability to block the action of histamines on H1 receptors. The principal use is to treat allergies, hives, and other local and systemic hypersensitivity reactions. Some antihistamines can also be used in the control of insomnia, motion sickness, or vertigo. First-generation antihistamines can cause side effect of sedation. Second-generation antihistamines (fexofenadine, loratadine) are nonsedating. Loratadine is a white to off-white powder; insoluble in water; soluble in acetone, alcohol, and chloroform. It is chemically described as 4-(8-chloro-5,6-dihydro-11H-benzo[5,6] cyclohepta [1,2-b]pyridin- 11-ylidene)- 1-piperidinecarboxylate, ethyl ester. It is used an H1 receptor antagonist; administered orally. | ||
| SALES SPECIFICATION | ||
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APPEARANCE |
White powder | |
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IDENTIFICATION |
Complies ( IR spectrum) |
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ASSAY (HPLC) |
98.5 - 101.0% | |
| SOLUTION CLARITY | clear (in methanol) | |
| HEAVY METALS |
20ppm max |
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INDIVIDUAL IMPURITY |
0.5% max |
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| SULFATED ASH | 0.1% max | |
| TRANSPORTATION | ||
| PACKING | 25kgs in fiber drum | |
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| OTHER INFORMATION | ||
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