N,N'-CARBONYLDIIMIDAZOLE

N,N'-CARBONYLDIIMIDAZOLE

PRODUCT IDENTIFICATION

CAS NO.

530-62-1; 128456-94-0

N,N'-CARBONYLDIIMIDAZOLE

EINECS NO.

208-488-9

FORMULA

(C₃H₃N₂)₂CO

MOL WT.

162.15

H.S. CODE

TOXICITY

SYNONYMS

1,1'-Carbonylbis-1H-Imidazole; CDI;

1,1'-Carbonyldiimidazole; 1,1'-Carbonylbis-1H-imidazol (German); 1,1'-Carbonilbis-1H-imidazol (Spanish); 1,1'-carbonylbis-1H-imidazole (French); Diimidazol-1-yl ketone; N,N'-Carbonylbis(imidazole); 1-Oxomethylenebis(N-imidazole);

SMILES

CLASSIFICATION

COUPLING REAGENTS /

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE

white powder

MELTING POINT

117 - 122 C

BOILING POINT

SPECIFIC GRAVITY

SOLUBILITY IN WATER

Decomposes

VAPOR DENSITY

AUTOIGNITION

NFPA RATINGS

Health: 2; Flammability: 1; Reactivity:

REFRACTIVE INDEX

FLASH POINT

STABILITY

Stable under ordinary conditions. Moisture sensitive.

APPLICATIONS

N,N'-Carbonyldiimidazole is a white crystals with a melting point of 116 C. It is hydrolyzed by water quickly. It is used as a coupling agent for the synthesis of peptides. When reacted with amino acids or peptide esters, it releases the imidazole group to couple the peptides. CDI is also a very reactive reagent in organic synthesis, mainly in converting alcohols and amines into esters, amides, ketones, and ureas. The reactivity is similar to acid chlorides for the activation of acids as imidazolides reagent. CDI undergoes reaction with peroxide to form the peroxycarboxylic acid and imidazole group can be reduced to form aldehydes from the carboxylic acid. CDI reagent is also used to make beta-keto sulfones, sulfoxides and beta-enamino acid derivatives. CDI is a carbonyl-transfer reagent for the synthesis of various heterocycles.

CARBODIIMIDES

Product	CAS RN
N,N'-Dicyclohexylcarbodiimide	538-75-0
N,N'-Diphenylcarbodiimide	622-16-2
N,N'-Di-tert-butylcarbodiimide	691-24-7
N,N'-Diisopropylcarbodiimide	693-13-0
1,3-Di-p-tolylcarbodiimide	726-42-1
Bis(3-chloro-2-methylphenyl)carbodiimide	961-63-7
Bis(trimethylsilyl)carbodiimide	1000-70-0
Bis(o-tolylcarbodiimide)	1215-57-2
1-tert-Butyl-3-ethylcarbodiimide	1433-27-8
N-(3-Dimethylaminopropyl)-N'-ethylcarbodiimide	1892-57-5
Bis(2,6-diisopropylphenyl)carbodiimide	2162-74-5
Bis(2,6-diethylphenyl)carbodiimide	2162-75-6
N-Cyclohexyl-N'-(2-morpholinoethyl)carbodiimide metho-p-toluenesulfonate	2491-17-0
N-Cyclohexyl-N'-isopropylcarbodiimide	3496-83-1
N-Methyl-N'-phenylcarbodiimide	4172-91-2
1-Cyclohexyl-3-(2-(4-morpholinyl)ethyl)carbodiimide	15580-20-8
1-(3-(Dimethylamino)propyl)-3-ethylcarbodiimide methiodide	22572-40-3
N,N'-Dicyclohexyl-N-methylcarbodiimidium iodide	36049-77-1
N-(2,2,6,6-Tetramethylpiperidyl-1-oxyl) N'-(cyclohexyl)carbodiimide	42249-40-1
1-Ethyl-3-(4-azonia-4,4-dimethylpentyl)carbodiimide	45024-77-9
Bis(2,4,6-triisopropyl-3-isocyanatophenyl)carbodiimide	68083-39-6
1-Phenyl-3-trimethylaminopropyl carbodiimide	79322-24-0
N-Cyclohexyl-N'-(4-dimethylamino-alpha-naphthyl)carbodiimide	86332-16-3
N-Cyclohexyl-N'-(1-pyrenyl)carbodiimide	98540-87-5
1-Ethyl-3-(3-dimethylaminoethyl)carbodiimide	141650-20-6

SALES SPECIFICATION

APPEARANCE

white powder

ASSAY

98.0% min

TRANSPORTATION

PACKING

HAZARD CLASS

UN NO.

OTHER INFORMATION

Hazard Symbols: XI, Risk Phrases: 36/37/38, Safety Phrases: 24/25
Price: