N-(2-HYDROXYETHYL)PIPERAZINE

PRODUCT IDENTIFICATION
CAS NO. 103-76-4

N-(2-HYDROXYETHYL)PIPERAZINE

EINECS NO. 203-142-3
FORMULA C6H14N2O
MOL WT. 130.19

H.S. CODE

 

TOXICITY

 Oral rat LD50: 4920 ul/kg
SYNONYMS Hydroxyethylpiperazine;
1-(2-Hydroxyethyl)piperazine; 2-Piperazin-1-ylethanol (German); 2-piperazin-1-iletanol (Spanish); 2-pipérazine-1-yléthanol (French); 1-Piperazineethanol;
SMILES

 

CLASSIFICATION

  

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE 
clear to pale yellow liquid
MELTING POINT -10 C
BOILING POINT 246 C
SPECIFIC GRAVITY 1.06
SOLUBILITY IN WATER Miscible
pH  
VAPOR DENSITY

4.5

AUTOIGNITION

280 C

NFPA RATINGS Health: 1 ; Flammability: 1 ; Reactivity: 0

REFRACTIVE INDEX

  
FLASH POINT

135 C

STABILITY

Stable under ordinary conditions

GENERAL DESCRIPTION & APPLICATIONS
Piperazine is a heterocyclic compound containing four carbon atoms and two of nitrogen at 1,4 position ( als called 1,4-hexahydropyrazine). It is a deliquescent crystalline compound melting at 105 C; soluble in water, alcohol, glycerol, and glycols. It is used as a main ingredient of anthelmintics used to treat intestinal roundworms (ascariasis) infection in human and  poultry and to treat pinworms (enterobiasis; oxyuriasis) by altering cell membrane permeability and causing hyperpolarization of the membrane. Piperazine is a main moiety in psychoactive drugs. Certain piperazine derivatives are suspected of ecstasy substitutes. Benzylpiperazine is bannaed in many countries. Benzylpiperazine  has been used as a anthelmintic (antiparastic effect). Nitrogen in piperazine ring plays an important role in biological research and drug manufacturing industry including the preparation of anthelmintic, antiallergenic, antibacterial, antihistamic, antiemetic and antimigraine agents. The piperazine ring and piperazine derivatives are important cyclic components in industrial field as raw materials for hardener of epoxy resins, corrosion inhibitors, insecticides, accelerators for rubber, urethane catalysts and antioxidants. N-(2-Hydroxyethyl)piperazine is used in the synthesis of triethylene diamine which is an important catalyst in the production of polyurethane foams. It is used as an intermediate of drugs like antipsychotic agent ( fluphenazine), dyes, agrochemicals, surfactants and other chemical compounds.
SALES SPECIFICATION
APPEARANCE 
clear to pale yellow liquid

PURITY

99.5% min

WATER

 0.5% max

INDIVIDUAL IMPURITY

0.5% max
TRANSPORTATION
PACKING
200kgs in a drum
HAZARD CLASS  
UN NO.  
OTHER INFORMATION
Hazard Symbols: XI, Risk Phrases: 38-41, Safety Phrases: 26-37