| CAS
NO. |
6284-40-8 |
|
| EINECS NO. |
228-506-9 |
| FORMULA |
CH3NHCH2(CHOH)4CH2OH |
| MOL
WT. |
195.22 |
|
H.S.
CODE
|
2922.19 |
|
TOXICITY
|
|
| SYNONYMS |
1-Deoxy-1-methylaminosorbitol;
N-Methyl-d-glucamine;
|
|
SMILES |
|
|
CLASSIFICATION
|
|
|
PHYSICAL AND CHEMICAL PROPERTIES
|
| PHYSICAL
STATE |
white powder |
| MELTING POINT |
128 - 132 C |
| BOILING
POINT |
|
| SPECIFIC GRAVITY |
|
| SOLUBILITY
IN WATER |
|
| pH |
|
| VAPOR DENSITY |
|
|
AUTOIGNITION
|
350
C
|
|
NFPA
RATINGS
|
Health: 0; Flammability: 0; Reactivity: 1 |
|
REFRACTIVE
INDEX
|
|
| FLASH
POINT |
|
| STABILITY |
Stable
under ordinary conditions |
|
GENERAL
DESCRIPTION AND APPLICATIONS
|
|
Glucamine, 1-amino-1-deoxy-D-sorbitol, is an amine formed by reduction of
glucosylamine or glucose oxime. N-alkylated glucamines are prepared from
D-glucose and relevant alkylamines. Meglumine is N-methyl glucamine, a derivative of sorbitol in which the hydroxyl group in position 1 is replaced
by a methylamino group. It is a
white crystalline powder; melting at 130 C. Meglumine is used in the preparation
of certain radiopaque media such as diatrizoate meglumine and iodipamide
meglumine. Meglumine is combined as an excipient (an inert substance) not an
active ingredient. Excipients are added to ensure that the shelf-life of the active ingredients can be long enough
to be active until internal use. Excipients are combined also to support the active ingredients, so that the latter
can be easily administered or absorbed in the body. Examples of
meglumine-combined drugs are flunixin meglumine (non-steroidal anti-inflammatory
drugs, used as a veterinary anti-inflammatory and analgesic) and meglumine
antimoniate (antiprotozoal to treat leishmaniasis). Meglumine is used in
ion-exchange resins to chelate boron ions selectively. N-alkyl glucamines are used in
preparing functional surfactants and some solutions which are stable over a wide range of pH and ionic strength. |
| SALES
SPECIFICATION |
|
APPEARANCE
|
white
powder |
|
ASSAY
|
99.0%
min
|
|
OPTICAL
ROTATION
|
-15.5°
~ -17.5°
|
|
LOSS
ON DRYING
|
0.5%
max
|
| TRANSPORTATION |
| PACKING |
25kgs
in fiber drum |
| HAZARD CLASS |
|
| UN
NO. |
|
| OTHER
INFORMATION |
|
Hazard
Symbols: , Risk Phrases: , Safety Phrases: 24/25 |
|
EXAMPLES OF
EXCIPIENT |
| Excipient |
CAS
RN
|
| Acacia
gum |
9000-01-5 |
| Calcium sulfate |
7778-18-9 |
| Carboxymethylcellulose
Sodium |
9004-32-4 |
| Carrageenan
gum |
9000-07-1 |
| Crospovidone |
9003-39-8 |
| 1-Deoxy-1-(octylamino)-D-glucitol |
23323-37-7 |
| Dimethyl sulfoxide |
67-68-5 |
| Dioctyl sulfosuccinic acid
and its salts |
|
| Fosveset |
193901-91-6 |
| Gelatin |
9000-70-8 |
| Hydroxypropyl
methylcellulose |
9004-65-3 |
| Karaya gum |
9000-36-6 |
| Laurocapram |
59227-89-3 |
| Meglumine |
6284-40-8 |
| Nonoxynol
|
26027-38-3 |
| N-Stearoylglycine
|
158305-64-7 |
| Octabenzone |
1843-05-6 |
| Octoxynol |
9002-93-1 |
| Phthaloyl chloride |
88-95-9 |
| Polipropene |
9003-07-0 |
| Poloxamer |
106392-12-5 |
| Polyethylene glycol ethers |
25322-68-3 |
| Propyleneglycol
esters |
|
| Sorbitol
|
50-70-4 |
| Sucrose |
57-50-1 |
| Talc |
14807-96-6 |
| Taurodeoxycholic acid
|
516-50-7 |
| Tragacanth
|
9000-65-1 |
| Tricaprilin |
538-23-8 |
| Tromethamine |
77-86-1 |
|