NAFTOPIDIL DIHYDROCHLORIDE

PRODUCT IDENTIFICATION

CAS NO. 57149-07-2

NAFTOPIDIL

EINECS NO.  
FORMULA C24H28N2O3·2HCl
MOL WT. 465.42

H.S. CODE

 

TOXICITY

 
SYNONYMS  
4-(2-Methoxyphenyl)-alpha-((1-naphthalenyloxy)methyl)-1-pioerazineethanol dichloride; (+-)-1-(4-(2-Methoxyphenyl)piperazinyl)-3-(1-naphthyloxy)propan-2-ol dichloride;
SMILES

 

CLASSIFICATION

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE

white to off-white crystalline powder

MELTING POINT 125 - 126 C
BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER Insoluble
pH  
VAPOR DENSITY

 

AUTOIGNITION

 

NFPA RATINGS  

REFRACTIVE INDEX

 
FLASH POINT  
STABILITY

Stable under ordinary conditions.

GENERAL DESCRIPTION & APPLICATIONS

Naftopidil, an alpha1-adrenoceptor antagonist, is used to treat benign prostatic hypertrophy (BPH) which causes urinary problems by prostate gland enlargement. It acts to smooth muscles of the prostate and thus increase urinary flow rate; known as more effective than finasteride. Chemically it is described as (+-)-1-(4-(2-Methoxyphenyl) piperazinyl)- 3-(1-naphthyloxy)propan-2-ol. The dichloride salt of naftopidil is a white crystalline powder; insoluble in water, soluble in methanol; 125 - 126 C; administered orally.
SALES SPECIFICATION

APPEARANCE

white crystalline powder

IDENTIFICATION

Complies Test A,B

PURITY

99.0 - 101.0%

MELTING POINT

125 - 126 C

HEAVY METALS

10ppm max

LOSS ON DRYING

0.5% max

RESIDUE OF IGNITION

0.1% max
TRANSPORTATION
PACKING
 
HAZARD CLASS  
UN NO.  
OTHER INFORMATION