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| NAFTOPIDIL DIHYDROCHLORIDE | ||
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PRODUCT IDENTIFICATION |
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| CAS NO. | 57149-07-2 |
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| EINECS NO. | ||
| FORMULA | C24H28N2O3·2HCl | |
| MOL WT. | 465.42 | |
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H.S. CODE |
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TOXICITY |
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| SYNONYMS | ||
| 4-(2-Methoxyphenyl)-alpha-((1-naphthalenyloxy)methyl)-1-pioerazineethanol dichloride; (+-)-1-(4-(2-Methoxyphenyl)piperazinyl)-3-(1-naphthyloxy)propan-2-ol dichloride; | ||
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CLASSIFICATION |
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PHYSICAL AND CHEMICAL PROPERTIES |
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| PHYSICAL STATE |
white to off-white crystalline powder |
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| MELTING POINT | 125 - 126 C | |
| BOILING POINT | ||
| SPECIFIC GRAVITY | ||
| SOLUBILITY IN WATER | Insoluble | |
| pH | ||
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| AUTOIGNITION |
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REFRACTIVE INDEX |
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| FLASH POINT | ||
| STABILITY |
Stable under ordinary conditions. |
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GENERAL DESCRIPTION & APPLICATIONS |
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| Naftopidil, an alpha1-adrenoceptor antagonist, is used to treat benign prostatic hypertrophy (BPH) which causes urinary problems by prostate gland enlargement. It acts to smooth muscles of the prostate and thus increase urinary flow rate; known as more effective than finasteride. Chemically it is described as (+-)-1-(4-(2-Methoxyphenyl) piperazinyl)- 3-(1-naphthyloxy)propan-2-ol. The dichloride salt of naftopidil is a white crystalline powder; insoluble in water, soluble in methanol; 125 - 126 C; administered orally. | ||
| SALES SPECIFICATION | ||
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APPEARANCE |
white crystalline powder | |
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IDENTIFICATION |
Complies Test A,B |
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| PURITY |
99.0 - 101.0% |
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| MELTING POINT |
125 - 126 C |
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HEAVY METALS |
10ppm max |
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LOSS ON DRYING |
0.5% max |
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RESIDUE OF IGNITION |
0.1% max | |
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| OTHER INFORMATION | ||
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