| CAS
NO. |
50-65-7 |
|
| EINECS
NO. |
200-056-8 |
| FORMULA |
C13H8Cl2N2O4 |
| MOL
WT. |
327.12 |
|
H.S.
CODE
|
|
|
TOXICITY
|
|
| SYNONYMS |
|
| 2',5-dichloro-4'-nitrosalicylanilide;
2-Hydroxy-5-chloro-N-(2-chloro-4-nitrophenyl)benzamide;
5-Chloro-2'-chloro-4'-nitrosalicylanilide;
5-Chloro-N-(2-chloro-4-nitrophenyl)salicylamide; Bayluscid; 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxy
Benzamide; Dichlosale; Cestocid; Devermine;
|
| SMILES |
|
| CLASSIFICATION
|
|
|
PHYSICAL
AND CHEMICAL PROPERTIES
|
| PHYSICAL
STATE |
white
to yellowish
odourless crystalline powder |
| MELTING
POINT |
224
- 229 C |
| BOILING
POINT |
|
| SPECIFIC
GRAVITY |
|
| SOLUBILITY
IN WATER |
Insoluble |
| pH |
|
| VAPOR
DENSITY |
|
| AUTOIGNITION |
|
| NFPA
RATINGS |
|
|
REFRACTIVE
INDEX
|
|
| FLASH
POINT |
|
| STABILITY |
Stable
under ordinary conditions. |
|
GENERAL
DESCRIPTION & APPLICATIONS
|
| Niclosamide is a chlorinated salicylanilide pesticide principally used against
aquatic vertebrates and crustaceans.It is an anthelmintic effective in the
treatment of diphyllobothriasis, diphyllobothriasis, hymenolepiasis. It is used
to treat broad tapeworms (or fish, dwarf and beef). Niclosamide is a white to
yellowish
odourless crystalline powder; melting point 224 C; not soluble in water;
sparingly soluble in ether, ethanol, chloroform, and soluble in acetone;
administered orally to humans, cats, and dogs. The commercially available
ethanolamine salt issolves in distilled water. Anthelmintic (also spelled anthelminthic) is a chemical substance used to expel
or destroy tapeworms in domestic animals. Some common anthelmintic active
ingredients classified by chemical structure include;
- Benzimidazoles
- Albendazole
(CAS #: 54965-21-8)
- Fenbendazole
(CAS #: 43210-67-9)
- Mebendazole
(CAS #: 31431-39-7)
- Oxfendazole
(CAS #: 53716-50-0)
- Oxibendazole
((CAS #: 20559-55-1)
- Triclabendazole (CAS #: 68786-66-3)
- Diphenylsulfides
- Bithionol (CAS
#:97-18-7)
- Febantel (CAS
#: 58306-30-2)
- Hexahydropyrazines
- Diethylcarbamazine (CAS
#: 90-89-1)
- Piperazine
(CAS #: 110-85-0)
- Praziquantel
(CAS #: 55268-74-1)
- Imidazothiazoles
-
Levamisole (CAS
#: 14769-73-4)
- Tetramisol (CAS
#: 5036-02-2)
- Macrocylic
Lactones
- Abamectin
(CAS #: 71751-41-2)
- Doramectin
(CAS #: 117704-25-3)
- Eprinomectin (CAS
#: 123997-26-2)
- Eprinomectin B1a (CAS#:
133305-88-1)
- Eprinomectin B1b (CAS
#: 133305-89-2)
- Ivermectin (CAS
#: 70288-86-7)
- Ivermectin B1a (CAS #: 70161-11-4)
- Ivermectin B1b (CAS #: 70209-81-3)
- Moxidectin
(CAS #: 113507-06-5)
- Salicylanilide
- Closantel (CAS
#: 57808-65-8)
- Niclosamide
Base (CAS #: 50-65-7)
- Niclosamide Monohydrate (CAS #: 7336-56-2)
- Niclosamide Ethanolamine salt (CAS #: 1420-04-8)
- Niclosamide Piperazine salt (CAS #: 34892-17-6)
- Oxyclozanide (CAS
#: 2277-92-1)
- Rafoxanide
(CAS #: 22662-39-1)
- Tetrahydropyrimidines
- Morantel (CAS
#: 20574-50-9)
- Pytrantel Pamoate (CAS
#: 22204-24-6)
- Others
- Clorsulon (CAS
#: 60200-06-8)
- Nitroxinil (CAS
#: 1689-89-0)
|
| SALES
SPECIFICATION (as per B.P STANDARD) |
|
NICLOSAMIDE
BASE
|
|
APPEARANCE
|
white
to yellowish
odourless crystalline powder |
|
IDENTIFICATION
|
Complies
Test A, B
|
|
ASSAY
|
98.0
- 102.0%
|
|
CHLORIDE
|
0.05%
max
|
|
RELATED
SUBSTANCES
|
0.1%
max
|
|
WATER
|
0.5%
max
|
|
SULFATED
ASH
|
0.1%
max
|
|
NICLOSAMIDE PIPERAZINE SALT
|
|
ASSAY
|
98.0
- 102.0%
|
|
PIPERAZINE
|
10.0
- 13.0%
|
|
NICLOSAMIDE ETHANOLAMINE SALT
|
|
ASSAY
|
50.0%
min, 70.0% min, 83.0% min, 94.0% min
|
|
NICLOSAMIDE
|
42.0%
min, 59.0% min, 70.0% min
|
| TRANSPORTATION |
| PACKING |
25kgs
in fiber drum
|
| HAZARD
CLASS |
|
| UN
NO. |
|
| OTHER
INFORMATION |
| Hazard Symbols: T, Risk Phrases: 61-36/37/38,
Safety Phrases: 53-26-37/39-45 |
GENERAL
DESCRIPTION OF SALICYLANILIDE
|
Salicylic
Acid is a white crystalline powder or needle-shaped
crystals with sweetish taste; soluble in acetone, ether,
alcohol,
boiling water, benzene and
turpentine,
sparingly soluble in chloroformbenzene,
slightly soluble in water; melts at 158 C. It is prepared
commercially by sodium salicylate which derived from
sodium phenolate with carbon dioxide under heating and
pressure. It contains both a hydroxyl and a carboxyl
group, which react with either an acid or an alcohol.
The carboxyl group forms esters with alcohols; e.g.
methyl salicylate is formed with methanol, which used
in food flavorings and preservatives; menthyl salicylate
is formed with methanol, which is used in suntan lotions;
phenyl salicylate (called salol) is formed with phenol,
which is used as an antiseptic and antipyretic agent.
The hydroxyl group reacts with acetic acid to form acetylsalicylic
acid (called aspirin). Salicylic Acid is important for
the preparation of other pharmaceutical products, dyes,
flavours, and preservatives. The sodium salt (Sodium
salicylate), a shiny white powder, is used for antiseptics
preparations and as a preservative. Salicylic
Acid derivatives are used in formulating flavors,
preservatives and UV
absorbers for food and cosmetics as well as plastics.
They are used in manufacturing pharmaceuticals mainly
analgestics and antipyretics for the relief of pain
and fever. Anilide is an amide in which one or more hydrogens are replaced by phenyl;
having the C6H5NH2-group. Brominated salicylanilides are used as disinfectants with antibacterial and
antifungal activities, used mainly in medicated soaps. Bromsalans are examples:
- Dibromsalan (CAS #: 87-12-7):
4',5-Dibromosalicylanilide
- Metabromsalan (CAS #: 2577-72-2):
3,5-Dibromosalicylanilide
- Tribromsalan (CAS #: 87-10-5):
3,4',5-Tribromosalicylanilide
Some salicylanilide derivatives are used as
aromatic amide pesticides and anthelmintics.
|