NIMODIPINE

PRODUCT IDENTIFICATION
CAS NO. 66085-59-4

NIMODIPINE
EINECS NO. 266-127-0
FORMULA C21H26N2O7
MOL WT. 418.45

H.S. CODE

  

TOXICITY

  
SMILES

 
SYNONYMS  
1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-Pyridinedicarboxylic acid 2-methoxyethyl 1-methylethyl ester; (1S,2R)-D-erythro-2-(N-Myristoylamino)-1-phenyl-1-propanol; Isopropyl (2-methoxyethyl)1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5- pyridine dicarboxylate

CLASSIFICATION

  

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE yellow crystalline powder
MELTING POINT 123 - 126 C
BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER Insoluble
pH  
VAPOR DENSITY

 

AUTOIGNITION

 

NFPA RATINGS

  

REFRACTIVE INDEX

 
FLASH POINT  
STABILITY

Stable under ordinary conditions.

APPLICATIONS
Calcium ions are needed for electrical activity for the contraction of cardiac and smooth muscle and conduction of nerve cell. Calcium channel blocker is a drug which inhibits the entry of excess calcium into cells and/or prevents form the mobilization of calcium from intracellular stores, resulting in relaxation of blood vessel walls and cardiac muscle for blood to flow more freely, lowering blood pressure thereby reducing oxygen demand in the heart and relieving anginal pain. It is used in the treatment of angina, cardiac arrhythmias, and hypertension.

Some major calcium channel blockers upon chemical structure are:

  • Dihydropyridine calcium channel blockers ; Amlodipine, Lacidipine, Lercanidipine, Nicardipine, Nifedipine, Nisoldipine, Nitrendipine, Nimodipine.
  • Phenylalkylamine calcium channel blockers ; Gallopamil, Verapamil
  • Benzothiazepine calcium channel blockers Diltiazem
  • Diarylaminopropylamine ethers: Bepridil, Mibefradil

Nimodipine is used as a vasodilator in the treatment of cerebral arterial spasm following subarachnoid hemorrhage from a ruptured intracranial aneurysm. The chemical designation is 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-Pyridinedicarboxylic acid 2-methoxyethyl- 1-methylethyl ester. It is a  yellow crystalline powder; insoluble in water, soluble in alcohol, chloroform and ethyl acetate; melting point 123-126 C; administered orally.
SALES SPECIFICATION

APPEARANCE

 yellow crystalline powder

IDENTIFICATION

Complies Test A,B

ASSAY (HPLC)

98.0 - 101.5% (Anhydrous basis)

IMPURITY

1.0% max (Individual impurity: 0.5% max)

RESIDUE ON IGNITION

0.2% max

HEAVY METALS

10ppm max

MELTING POINT

123 - 126 C
TRANSPORTATION
PACKING
 
HAZARD CLASS  
UN NO.  
OTHER INFORMATION
Hazard Symbols: XN, Risk Phrases: 20/21/22, Safety Phrases: 36