NISOLDIPINE

NISOLDIPINE
PRODUCT IDENTIFICATION
CAS NO.	63675-72-9, 103573-36-0, 103573-38-2
EINECS NO.	264-407-7
FORMULA	C₂₀H₂₄N₂O₆
MOL WT.	388.42
H.S. CODE	2933.39.4100
TOXICITY	Oral Rat LD50: 1257mg/kg
SYNONYMS	Nisoldipino; Nisocor; Nisoldipino; Nisoldipinum; Sular;
1,4-Dihydro-2,6- dimethyl-4-(2-nitrophenyl)-3,5-pyridine dicarboxylic acid, methyl 2-methylpropyl ester; Iosbutyl methyl-1,4-dihydro-2,6-dimethyl-4-(o- nitrophenyl)-3,5- pyridinedicarboxylate; Isobutyl 1,4-dihydro-5-methoxycarbonyl-2,6-dimethyl-4-(2-nitrophenyl)-3-pyridincarboxylate;
SMILES	c1([C@@H]2C(=C(NC(=C2C(OC)=O)C)C)C(OCC(C)C)=O)c(cccc1) [N+](=O)[O-]
CLASSIFICATION	Antihypertensive agent, Calcium channel blocker, Cardiovascular Agent, Vasodilator agent, Dihydropyridine
EXTRA NOTES	A dihydropyridine calcium channel antagonist that acts as a potent arterial vasodilator and antihypertensive agent. It is also effective in patients with cardiac failure and angina. L-type (CaV1.2) calcium channel blocker; dihydropyridine-type calcium channel blocker with selectivity for smooth muscle (CaV1.2b) over cardiac muscle (CaV1.2a). Arterial vasodilator and antihypertensive agent.
PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE	yellow crystalline powder
MELTING POINT	150 - 155 C
BOILING POINT
SPECIFIC GRAVITY
SOLUBILITY IN WATER	Insoluble
pH	soluble in acetone, ethanol and methanol
VAPOR DENSITY
AUTOIGNITION
log P	3.26 (Octanol-water)
VAPOR PRESSURE	3.04E-09 (mmHg at 25 C)
HENRY LAW CONSTANT	1.71E-13 (atm-m3/mole at 25 C)
OH RATE CONSTANT	1.17E-10 (cm3/molecule-sec at 25 C Atmospheric)
NFPA RATINGS	Health hazard: 1, Fire: 0, Reactivity Hazard: 0
REFRACTIVE INDEX
FLASH POINT
STABILITY	Stable under ordinary conditions.
EXTERNAL LINKS & GENERAL DESCRIPTION
Wikipedia Linking Google Scholar Search Drug Information Portal (U.S. National Library of Medicine) - Nisoldipine PubChem Compound Summary - Nisoldipine http://www.nejm.org/doi/ The Effect of Nisoldipine as Compared with Enalapril on Cardiovascular Outcomes in Patients with Non-Insulin-Dependent Diabetes and Hypertension Local: Calcium ions are needed for electrical activity for the contraction of cardiac and smooth muscle and conduction of nerve cell. Calcium channel blocker is a drug which inhibits the entry of excess calcium into cells and/or prevents form the mobilization of calcium from intracellular stores, resulting in relaxation of blood vessel walls and cardiac muscle for blood to flow more freely, lowering blood pressure thereby reducing oxygen demand in the heart and relieving anginal pain. It is used in the treatment of angina, cardiac arrhythmias, and hypertension. Some major calcium channel blockers upon chemical structure are: Dihydropyridine calcium channel blockers ; Amlodipine, Lacidipine, Lercanidipine, Nicardipine, Nifedipine, Nisoldipine, Nitrendipine, Nimodipine. Phenylalkylamine calcium channel blockers ; Gallopamil, Verapamil Benzothiazepine calcium channel blockers Diltiazem Diarylaminopropylamine ethers: Bepridil, Mibefradil Nisoldipine is used in the treatment of high blood pressure. The chemical designation is 1,4-Dihydro-2,6-dimethyl-4-(2- nitrophenyl)-3,5- pyridine dicarboxylic acid, methyl 2-methylpropyl ester; It is a yellow crystalline powder; insoluble in water , soluble in ethanol, ethyl acetate, chloroform; melting point 150 - 155 C; administered orally.
SALES SPECIFICATION
APPEARANCE	yellow crystalline powder
IDENTIFICATION	Complies Test A,B
ASSAY (HPLC)	98.0 - 102.0%
IMPURITY	1.0% max (Individual impurity: 0.5% max)
LOSS ON DRYING	1.0% max
HEAVY METALS	10ppm max
MELTING POINT	150 - 155 C
TRANSPORTATION
PACKING
HAZARD CLASS
UN NO.
SAFETY INFORMATION
HAZARD OVERVIEW	OSHA Hazards:Target Organ Effect, Harmful by ingestion., Harmful by skin absorption. Target Organs:Cardiovascular system.
GHS
SIGNAL WORD	Warning
PICTOGRAMS
HAZARD STATEMENTS	H302 + H312 Harmful if swallowed or in contact with skin
PRECAUTIONARY STATEMENTS	P280 Wear protective gloves/ protective clothing.
EC DIRECTIVES
HAZARD CODES	Xn Harmful
RISK PHRASES	20/21/22: Harmful by inhalation, in contact with skin and if swallowed
SAFETY PHRASES	36 Wear suitable protective clothing
PRICE INFORMATION