NITRENDIPINE

PRODUCT IDENTIFICATION
CAS NO. 39562-70-4

NITRENDIPINE
EINECS NO. 254-513-1
FORMULA C18H20N2O6
MOL WT. 360.37

H.S. CODE

  

TOXICITY

  
SYNONYMS  
1,4-Dihydro-2,6-dimethyl-4-(meta-nitrophenyl)-3,5-pyridinedicarboxylic aicd, ethyl methyl ester; Ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(meta-nitrophenyl)-3,5- pyridine dicarboxylate;
SMILES

 

CLASSIFICATION

  

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE yellow crystalline powder
MELTING POINT 156 - 160 C
BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER Insoluble
pH  
VAPOR DENSITY

 

AUTOIGNITION

 

NFPA RATINGS

  

REFRACTIVE INDEX

 
FLASH POINT  
STABILITY

Stable under ordinary conditions.

APPLICATIONS
Calcium ions are needed for electrical activity for the contraction of cardiac and smooth muscle and conduction of nerve cell. Calcium channel blocker is a drug which inhibits the entry of excess calcium into cells and/or prevents form the mobilization of calcium from intracellular stores, resulting in relaxation of blood vessel walls and cardiac muscle for blood to flow more freely, lowering blood pressure thereby reducing oxygen demand in the heart and relieving anginal pain. It is used in the treatment of angina, cardiac arrhythmias, and hypertension.

Some major calcium channel blockers upon chemical structure are:

  • Dihydropyridine calcium channel blockers ; Amlodipine, Lacidipine, Lercanidipine, Nicardipine, Nifedipine, Nisoldipine, Nitrendipine, Nimodipine.
  • Phenylalkylamine calcium channel blockers ; Gallopamil, Verapamil
  • Benzothiazepine calcium channel blockers Diltiazem
  • Diarylaminopropylamine ethers: Bepridil, Mibefradil

 

Nitrendipine is used in the treatment of high blood pressure. The chemical structure is related with nifedipine but nitro griop is at meta position. It is characterized in the peripheral circulation, reducing both systolic and diastolic pressures.  The chemical designation is 1,4-Dihydro-2,6-dimethyl-4-(meta-nitrophenyl)-3,5-pyridinedicarboxylic aicd, ethyl methyl ester. It is a yellow crystalline powder; insoluble in water , slightly soluble in methanol; soluble in chloroform and acetone; melting point 156 - 160 C; administered orally.
SALES SPECIFICATION

APPEARANCE

 yellow crystalline powder

IDENTIFICATION

Complies Test A,B

ASSAY (HPLC)

98.0 - 102.0%

IMPURITY

1.0% max
(Individual impurity: 0.2% max, Nitrosophenylpyridine: 0.2% max)

LOSS ON DRYING

0.5% max

SULFATED ASH

0.5% max

HEAVY METALS

10ppm max

MELTING POINT

156 - 160 C
TRANSPORTATION
PACKING
 
HAZARD CLASS  
UN NO.  
OTHER INFORMATION
Hazard Symbols: XN, Risk Phrases: 20/21/22, Safety Phrases: 36