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NORPHENAZONE
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PRODUCT IDENTIFICATION |
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| CAS NO. | 89-25-8 |
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| EINECS NO. | 201-891-0 | |
| FORMULA | C10H10N2O | |
| MOL WT. | 174.20 | |
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H.S. CODE |
2933.19 | |
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TOXICITY |
Oral rat LD50: 1915 mg/kg | |
| SYNONYMS | 3-Methyl-1-phenyl-2-pyrazolin-5-one; Norantipyrine; | |
| 2,4-Dihydro-5-methyl-2-phenyl-3H-pyrazol-3-one; Phenylmethylpyrazolone; 1-Phenyl-3-methyl-5-oxo-2-pyrazoline; 3-methyl-1-phenyl-5-pyrazolone; C.I. developer 1; developer z; 1-phenyl-3-methylpyrazolone-5; 1-Fenyl-3-methyl-2-pyrazolin-5-on; 1-Phenyl-3-methylpyrazolone-5; | ||
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CLASSIFICATION |
PYRAZOLONES / | |
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PHYSICAL AND CHEMICAL PROPERTIES |
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| PHYSICAL STATE | light yellow crystalline powder | |
| MELTING POINT | 129 -130 C | |
| BOILING POINT | Decomposes | |
| SPECIFIC GRAVITY | ||
| SOLUBILITY IN WATER | Soluble in hot water | |
| pH | ||
| VAPOR DENSITY |
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| AUTOIGNITION |
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| NFPA RATINGS | Health: 1; Flammability: 0; Reactivity: 0 | |
| REFRACTIVE INDEX |
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| FLASH POINT | ||
| STABILITY |
stable under ordinary conditions. Light sensitive | |
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APPLICATIONS |
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| Pyrazolone is a five-membered lactam ring compound containing two nitrogens and ketone in the same molecule. Lactam structure is an active nucleuses in pharmacological activity. Pyrazolone is an active moiety as a pharmaceutical ingredient, especially in the class of nonsteroidal antiinflammatory agents used in the treatment of arthritis and other musculoskeletal and joint disorders. The term of pyrazolone sometimes refers to nonsteroidal anti-inflammatory agents. Antipyrine (also called phenazone) is a pyrazolone class analgesic agent in otic solutions in combination with other analgesic such as benzocaine, and phenylephrine. Antipyrine has been used as an antipyretic, but replaced due to the possibility of agranulocytosis side effect. Lactams have big demand in artificial fibre industry. Pyrazolone derivatives, as lactam structure related compounds, are also widely used in preparing dyes and pigments. Norphenazone possibly can be used in the synthesis of drugs (antipyretic and analgesic medicines), dyes, pesticides and other organic compounds. The prefix "nor-" describes normal structure which has no branched chain of carbon atoms. In case of norphenazone, it has one less methylene group than its homologue, antipyrine. Pyrazolone class NSAID (nonsteroidal anti-inflammatory drug) includes phenylbutazone, oxyphenbutazone, dipyrone, and ramifenazone. | ||
| SALES SPECIFICATION | ||
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APPEARANCE |
light yellow crystalline powder | |
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ASSAY |
99.0% min |
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| MELTING POINT | 129 -130 C | |
| LOSS ON DRYING |
0.5% max |
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| TRANSPORTATION | ||
| PACKING | 25kgs
in bag | |
| HAZARD CLASS | not regulated | |
| UN NO. | ||
| REMARKS | ||
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Hazard
Symbols: n/a, Risk Phrases: n/a, Safety Phrases: 24/25
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