NORPHENAZONE

PRODUCT IDENTIFICATION

CAS NO. 89-25-8

NORPHENAZONE

EINECS NO. 201-891-0
FORMULA C10H10N2O
MOL WT. 174.20

H.S. CODE

2933.19

TOXICITY

Oral rat LD50: 1915 mg/kg
SYNONYMS 3-Methyl-1-phenyl-2-pyrazolin-5-one; Norantipyrine;
2,4-Dihydro-5-methyl-2-phenyl-3H-pyrazol-3-one; Phenylmethylpyrazolone; 1-Phenyl-3-methyl-5-oxo-2-pyrazoline; 3-methyl-1-phenyl-5-pyrazolone; C.I. developer 1; developer z; 1-phenyl-3-methylpyrazolone-5; 1-Fenyl-3-methyl-2-pyrazolin-5-on; 1-Phenyl-3-methylpyrazolone-5;
SMILES

 

CLASSIFICATION

PYRAZOLONES /

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE light yellow crystalline powder
MELTING POINT 129 -130 C
BOILING POINT Decomposes
SPECIFIC GRAVITY  
SOLUBILITY IN WATER Soluble in hot water
pH  
VAPOR DENSITY

 

AUTOIGNITION

 

NFPA RATINGS Health: 1; Flammability: 0; Reactivity: 0

REFRACTIVE INDEX

 
FLASH POINT  
STABILITY

stable under ordinary conditions. Light sensitive

APPLICATIONS

Pyrazolone is a five-membered lactam ring compound containing two nitrogens and ketone in the same molecule. Lactam structure is an active nucleuses in pharmacological activity. Pyrazolone is an active moiety as a pharmaceutical ingredient, especially in the class of nonsteroidal antiinflammatory agents used in the treatment of arthritis and other musculoskeletal and joint disorders. The term of pyrazolone sometimes refers to nonsteroidal anti-inflammatory agents. Antipyrine (also called phenazone) is a pyrazolone class analgesic agent in otic solutions in combination with other analgesic such as benzocaine, and phenylephrine. Antipyrine has been used as an antipyretic, but replaced due to the possibility of agranulocytosis side effect. Lactams have big demand in artificial fibre industry. Pyrazolone derivatives, as lactam structure related compounds, are also widely used in preparing dyes and pigments. Norphenazone possibly can be used in the synthesis of drugs (antipyretic and analgesic medicines), dyes, pesticides and other organic compounds. The prefix "nor-" describes normal structure which has no branched chain of carbon atoms. In case of norphenazone, it has one less methylene group than its homologue, antipyrine. Pyrazolone class NSAID (nonsteroidal anti-inflammatory drug) includes phenylbutazone, oxyphenbutazone, dipyrone, and ramifenazone.
SALES SPECIFICATION

APPEARANCE

light yellow crystalline powder

ASSAY

99.0% min

MELTING POINT 129 -130 C
LOSS ON DRYING

0.5% max

TRANSPORTATION
PACKING
25kgs in bag
HAZARD CLASS not regulated
UN NO.  
REMARKS
Hazard Symbols: n/a, Risk Phrases: n/a, Safety Phrases: 24/25