PRODUCT IDENTIFICATION

H.S. CODE

TOXICITY

CLASSIFICATION

PHYSICAL AND CHEMICAL PROPERTIES

REFRACTIVE INDEX

180 C

Stable under ordinary conditions

APPLICATIONS

Propiophenone (Phenyl ethyl ketone) is a useful intermediate to prepare nervous system drugs (anxiolytic and hypnotic drugs). Bupropion is an example which has propiophenone moiety. Bupropion is an aminoketone class antidepressant. Propiophenone is used in the synthesis of  ketoamphetamines such as cathinone and methcathinone. Propiophenone can also be converted to synthetic aryl alkenes such as cinnamic acids. some propiophenone derivatives such as paroxypropione (4-hydroxypropiophenone) is a drug called adrenergic beta-antagonist which bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety. Propiophenone is a constituent of synthetic perfumes, flavouring agents, and of paints to stabilize other ingredients. Ketones can be made by the oxidation of secondary alcohols and the destructive distillation of certain salts of organic acids. In addition to as polar solvents, ketones are important intermediates in the syntheses of organic compounds such as alkoxides, hydroxyalkynes, imines, alcohols (primary, secondary as well as tertiary), acetals, thioacetals, phosphine oxides, geminal diols, hydrazones, organic sulfite and cyanohydrins. Propiophenone is a clear liquid that is insoluble in water, but miscible with methanol, ethanol, diethyl ether, benzene and toluene.

Members of aryl ketone

APPEARANCE

PURITY

99.0% min

LOSS ON DRYING

0.5% max

RESIDUE ON IGNITION

0.2% max

HEAVY METALS

10ppm max