PROSTAGLANDIN A₁

PRODUCT IDENTIFICATION

14152-28-4

H.S. CODE

TOXICITY

9-Oxo-15S-hydroxy-prosta-10,13E-dien-1-oic acid; PGA1;

CLASSIFICATION

Anti-Infective, Antiviral

EXTRA NOTES

PHYSICAL AND CHEMICAL PROPERTIES

REFRACTIVE INDEX

Stable under ordinary conditions.

EXTERNAL LINKS & GENERAL DESCRIPTION

Wikipedia Linking

Google Scholar Search

Drug Information Portal (U.S. National Library of Medicine) - Prostaglandin A1

PubChem Compound Summary - Prostaglandin A1

Drug Bank -  Prostaglandin A1

KEGG (Kyoto Encyclopedia of Genes and Genomes) -  Prostaglandin A1

http://www.ebi.ac.uk/chebi/ -  Prostaglandin A1

http://www.ncbi.nlm.nih.gov/ -  Prostaglandin A1

Human Metabolome Database - Prostaglandin A1

Local:
Prostaglandin is any member of a group of physiologically active compounds derived from unsaturated 20-carbon polyunsaturated fatty acids, primarily arachidonic acid. Prostaglandins are lipids having two long side chains and a 5 carbon ring structure. They are found in normal human semen in highest concentrations. Their activities affect the nervous system, circulation, female reproductive organs, and metabolism similar to local hormone functions But they are not classified in hormones.

Prostaglandin belongs to eicosanoids, biologically active 20-carbon substances including prostaglandins, thromboxanes, prostacyclins, and leukotrienes. Eicosanoids are oxygenated hydrophobic cytokines, small proteins that are the core of communication between immune systems. Prostaglandins, thromboxanes, prostacyclins are derived via the cyclooxygenase pathway, while leukotrienes are via 5-lipoxygenase pathway. Prostaglandins are eicosanoids having a cyclopentane ring. Prostaglandins have two double bonds typically, while leukotrienes have four.

Prostaglandins act in the cells in which they are synthesized and surrounding cells, and their actions and effects vary with concentration, hormonal environment, and cell type. Prostaglandins mediate a wide range of physiological functions, such as control of blood pressure, regulation of muscle, glandular secretion, transmission of nerve impulses, and modulation of inflammation. Specific Prostaglandins designated by adding a letter on PG (the abbreviation for prostaglandin) to indicate the type of ring structure and a numerical subscript to indicate the number of double bonds. The subscript alpha or beta indicates the three-dimensional configuration of alcoholic groups attached to the ring structures. Alpha denotes a substituent below the plane of the ring, beta, above the plane.

APPEARANCE

ASSAY

98.0 % min