RAFOXANIDE

PRODUCT IDENTIFICATION
CAS NO. 22662-39-1

RAFOXANIDE
EINECS NO. 245-148-9
FORMULA C19H11Cl2I2NO3
MOL WT. 626.02

H.S. CODE

  
SMILES

 

TOXICITY

  
SYNONYMS Disalan; Flukanide;
N-(3-chloro-4-(4-chlorophenoxy)phenyl)-2-hydroxy-3,5-diiodobenzamide; 3'-Chloro-4'-(p-chlorophenoxy)-3,5-diiodosalicylanilide;

CLASSIFICATION

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE gray to yellow powder
MELTING POINT  
BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER Insoluble
pH  
VAPOR DENSITY

 
AUTOIGNITION

 
NFPA RATINGS  

REFRACTIVE INDEX

  
FLASH POINT

 
STABILITY

Stable under ordinary conditions.

GENERAL DESCRIPTION & APPLICATIONS
Rafoxanide is a salicylanilide class anthelmintic used in cattle and sheep. It is a gray to yellow powder; insoluble in water; slightly soluble in methanol. soluble in chloroform, ethyl Acetate. The chemical designation is 3’-Chloro-4’-(p-Chlorophenoxy)-3,5-diiodosalicyl anilide.

Anthelmintic (also spelled  anthelminthic) is a chemical substance used to expel or destroy tapeworms in domestic animals. Some common anthelmintic active ingredients classified by chemical structure include;

  • Benzimidazoles
    • Albendazole (CAS #: 54965-21-8)
    • Fenbendazole (CAS #: 43210-67-9)
    • Mebendazole (CAS #: 31431-39-7)
    • Oxfendazole (CAS #: 53716-50-0)
    • Oxibendazole ((CAS #: 20559-55-1)
    • Triclabendazole (CAS #: 68786-66-3)
  • Diphenylsulfides
    • Bithionol (CAS #:97-18-7)
    • Febantel (CAS #: 58306-30-2)
  • Hexahydropyrazines
    • Diethylcarbamazine (CAS #: 90-89-1)
    • Piperazine (CAS #: 110-85-0)
    • Praziquantel (CAS #: 55268-74-1)
  • Imidazothiazoles
    • Levamisole (CAS #: 14769-73-4)
    • Tetramisol (CAS #: 5036-02-2)
  • Macrocylic Lactones
    • Abamectin (CAS #: 71751-41-2)
    • Doramectin (CAS #: 117704-25-3)
    • Eprinomectin (CAS #: 123997-26-2)
      • Eprinomectin B1a (CAS#: 133305-88-1)
      • Eprinomectin B1b (CAS #: 133305-89-2)
    • Ivermectin (CAS #: 70288-86-7)
      • Ivermectin B1a (CAS #: 70161-11-4)
      • Ivermectin B1b (CAS #: 70209-81-3)
    • Moxidectin (CAS #: 113507-06-5)
  • Salicylanilide
    • Closantel (CAS #: 57808-65-8)
    • Niclosamide Base (CAS #: 50-65-7)
      • Niclosamide Monohydrate (CAS #: 7336-56-2)
      • Niclosamide Ethanolamine salt (CAS #: 1420-04-8)
      • Niclosamide Piperazine salt (CAS #: 34892-17-6)
    • Oxyclozanide (CAS #: 2277-92-1)
    • Rafoxanide  (CAS #: 22662-39-1)
  • Tetrahydropyrimidines
    • Morantel (CAS #: 20574-50-9)
    • Pytrantel Pamoate (CAS #: 22204-24-6)
  • Others
    • Clorsulon (CAS #: 60200-06-8)
    • Nitroxinil (CAS #: 1689-89-0)
SALES SPECIFICATION (as per B.P STANDARD)

APPEARANCE

 gray to yellow powder

IDENTIFICATION

Complies Test A, B

ASSAY

98.0 - 102.0%

CHLORIDE

0.25% max

LOSS ON DRYING

0.5% max

SULFATED ASH

0.1% max
TRANSPORTATION
PACKING
 
HAZARD CLASS  
UN NO.  
OTHER INFORMATION
Hazard Symbols: T, Risk Phrases: 61-36/37/38, Safety Phrases: 53-26-37/39-45

GENERAL DESCRIPTION  OF SALICYLANILIDE
Salicylic Acid is a white crystalline powder or needle-shaped crystals with sweetish taste; soluble in acetone, ether, alcohol, boiling water, benzene and turpentine, sparingly soluble in chloroformbenzene, slightly soluble in water; melts at 158 C. It is prepared commercially by sodium salicylate which derived from sodium phenolate with carbon dioxide under heating and pressure. It contains both a hydroxyl and a carboxyl group, which react with either an acid or an alcohol. The carboxyl group forms esters with alcohols; e.g. methyl salicylate is formed with methanol, which used in food flavorings and preservatives; menthyl salicylate is formed with methanol, which is used in suntan lotions; phenyl salicylate (called salol) is formed with phenol, which is used as an antiseptic and antipyretic agent. The hydroxyl group reacts with acetic acid to form acetylsalicylic acid (called aspirin). Salicylic Acid is important for the preparation of other pharmaceutical products, dyes, flavours, and preservatives. The sodium salt (Sodium salicylate), a shiny white powder, is used for antiseptics preparations and as a preservative. Salicylic Acid derivatives are used in formulating flavors, preservatives and UV absorbers for food and cosmetics as well as plastics. They are used in manufacturing pharmaceuticals mainly analgestics and antipyretics for the relief of pain and fever. Anilide is an amide in which one or more hydrogens are replaced by phenyl; having the C6H5NH2-group. Brominated salicylanilides are used as disinfectants with antibacterial and antifungal activities, used mainly in medicated soaps. Bromsalans are examples:
  • Dibromsalan (CAS #: 87-12-7): 4',5-Dibromosalicylanilide
  • Metabromsalan (CAS #: 2577-72-2): 3,5-Dibromosalicylanilide
  • Tribromsalan (CAS #: 87-10-5): 3,4',5-Tribromosalicylanilide

Some salicylanilide derivatives are used as aromatic amide pesticides and anthelmintics.