PRODUCT IDENTIFICATION

80214-83-1

C₄₁H₇₆N₂O₁₅

H.S. CODE

TOXICITY

O([C@H]1[C@@H]([C@@H](O[C@@H]2[C@@H]([C@@H](C[C@@H] (O2) C)N(C)C)O)[C@](C[C@H](\C([C@H](C)[C@H]([C@]([C@H] (OC([C@@H]1C)=O)CC)(C)O)O)=N/OCOCCOC)C)(C)O)C)[C@@ H]1C[C@@] ([C@@H](O)[C@@H](O1)C)(OC)C

CLASSIFICATION

PHYSICAL AND CHEMICAL PROPERTIES

AUTOIGNITION

NFPA RATINGS

REFRACTIVE INDEX

Stable under ordinary conditions

GENERAL DESCRIPTION & EXTERNAL LINKS

The macrolides, derived from Streptomyces bacteria, are a group of antibiotics that inhibits protein synthesis by bacteria at the 50S ribosome. They are characterized by a macrocyclic ring (a large ring molecule with many functional groups bonded to it) and a large lactone ring in the molecular structure. They are usually used for respiratory tract, skin, and genitourinary infections. Roxithromycin might be useful in treating toxoplasmosis, cryptosporidiosis, isospora (an infection which, like cryptosporidiosis, causes severe diarrhea), and possibly MAI. Cryptosporidiosis, a parasitic infection, often leads to severe diarrhea and weight loss and is potentially fatal. Unfortunately, there is no standard treatment for cryptosporidiosis. Roxithromycin is widely used in Latin America and Europe as a safe and effective treatment for a number of bacterial infections. Roxithromycin is similar to erythromycin in chemical structure and mechanism of action. This preparations are made from microcoated roxithromycin powder. This  preparations, which are removed of bitter taste of  roxithromycin and absorbed well into the gastrointestinal  tract, descrease the side effects, but  increase the safety.

The macrolides are:

• Azithromycin (CAS RN: 83905-01-5)
• Brefeldin A (CAS RN: 20350-15-6)
• Clarithromycin (CAS RN: 81103-11-9)
• Erythromycin (CAS RN: 114-07-8)
• Erythromycin Estolate (CAS RN: 3521-62-8)
• Erythromycin Ethyl Succinate (CAS RN: 1264-62-6)
• Erythromycin Stearate (CAS RN: 643-22-1)
• Josamycin (CAS RN: 16846-24-5)
• Kitasamycin (CAS RN: 1392-21-8)
• Lincomycin Hydrochloride (CAS RN: 859-18-7)
• Mepartricin (CAS RN: 11121-32-7)
• Midecamycin (CAS RN: 35457-80-8)
• Oleandomycin Phosphate (CAS RN: 7060-74-4)
• Oleandomycin Triacetate (CAS RN: 2751-09-9)
• Rokitamycin (CAS RN: 74014-51-0)
• Roxithromycin (CAS RN: 80214-83-1)
• Spiramycin (CAS RN: 8025-81-8)
• Tylosin (CAS RN: 74610-55-2)
• Tylosin Tartrate (CAS RN: 74610-55-2)
• Virginiamycin M (CAS RN: 21411-53-0)

Wikipedia Linking: http://en.wikipedia.org/wiki/Roxithromycin

http://www.druglib.com/
Mechanism of Action
Roxithromycin prevents bacteria from growing, by interfering with their protein synthesis. Roxithromycin binds to the subunit 50S of the bacterial ribosome, and thus inhibits the translocation of peptides. Roxithromycin has similar antimicrobial spectrum as erythromycin, but is more effective against certain gram-negative bacteria, particularly Legionella pneumophila.

http://www.freebase.com/
Macrolide Antibiotic: Drugs

APPEARANCE

pass

OPTICAL ROTATION

-93° ~ -96°

0.1% max

10ppm max

WATER

3.0% max

0.5% max ( Individual Impurities)

MACROLIDES