SCOPOLETIN

PRODUCT IDENTIFICATION

CAS NO. 92-61-5

SCOPOLETIN

EINECS NO. 202-171-9
FORMULA C10H8O4
MOL WT. 192.17

H.S. CODE

TOXICITY

SYNONYMS 7-Hydroxy-6-methoxycoumarin;
7-Hydroxy-6-methoxycumarin; 7-Hidroxi-6-metoxicumarina; 7-Hydroxy-6-méthoxycoumarine; 6-Methoxyumbelliferone; 7-Hydroxy-5-methoxycoumarin; Gelseminic acid; Chrysatropic acid; Esculetin-6-methyl ether; 7-Hydroxy-6-methoxy-2H-1-benzopyran-2-one;
SMILES

 

CLASSIFICATION

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE yellow to beige crystalline powder
MELTING POINT

200 - 207 C (Decomposes)

BOILING POINT

 

SPECIFIC GRAVITY

 

SOLUBILITY IN WATER Slightly soluble (freely soluble in acetic acid)
pH weak acidic
VAPOR DENSITY

 

AUTOIGNITION  

REFRACTIVE INDEX

 

NFPA RATINGS Health: 1; Flammability: 0; Reactivity: 0
FLASH POINT

 

STABILITY Stable under normal conditions.

GENERAL DESCRIPTION & APPLICATIONS

Coumarin (anhydride of o-coumaric acid) is white, crystalline lactone, obtainable naturally from several plants, such as tonka bean, lavender, sweet clover grass, strawberries, and cinnamon, or produced synthetically from an amino acid, phenylalanine. It is the principle of dicumarol which inhibits the hepatic synthesis of the vitamin Kā€“dependent coagulation factors. Coumarin derivatives are used widely as anticoagulants (such as warfarin, -OH group is attached at 4 position) for the treatment of disorders in which there is excessive or undesirable clotting, such as thrombophlebitis, pulmonary embolism, and certain cardiac conditions. Coumarin derivatives are also used as rodenticides due to the property of causing fatal hemorrhaging. Coumarin has the characteristic odour like that of vanilla beans. It is used for the preparation of perfumes, soaps, flavourings. The coumarin nucleus (benzo-2-pyrone) is derived cinnamic acid (phenylacrylic skeleton) in the biosynthesis. Accordingly, the hydroxy group attached to coumarin structure at 7 position is important in biosynthesis pathway. Umbelliferone (7-hydroxy coumarin), esculetin (6,7-Dihydroxycoumarin), scopoletin (7-hydroxy-6-methoxycoumarin) are the widespread coumarins in nature. Synthetic 7-hydroxy coumarins are used to absorb ultraviolet rays in sunscreen cosmetics and used in the synthesis of drugs especially anticancer. Scopoletin is used a peroxide or calcium signal during the oxidative burst. It is a acetylcholinesterase inhibitor.
SALES SPECIFICATION

APPEARANCE

yellow to beige crystalline powder
ASSAY

98.0% min

MELTING POINT

200 - 207 C

SULFATED ASH

0.2% max

LOSS ON DRYING

0.5% max

TRANSPORTATION
PACKING  
HAZARD CLASS  
UN NO.  
OTHER INFORMATION
Hazard Symbols: T, Risk Phrases: 23/24/25, Safety Phrases: 24/25