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| SULBACTAM | ||
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PRODUCT IDENTIFICATION |
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| CAS NO | 68373-14-8 |
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| EINECS NO. | 269-878-2 | |
| FORMULA | C8H11NO5S | |
| MOL WT. | 233.24 | |
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H.S. CODE |
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TOXICITY |
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| SYNONYMS | ||
| (2S, 5R)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0] heptane-2-carboxylate 4,4-dioxide; (2S, 5R)-(3,3-dimethyl-4,4,7-trioxo-4-thia-1- azabicyclo[3.2.0] hept-2ylcarboxylate; | ||
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CLASSIFICATION |
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PHYSICAL AND CHEMICAL PROPERTIES |
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| PHYSICAL STATE | white to off-white crystalline powder | |
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AUTOIGNITION |
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| STABILITY | Stable under ordinary conditions. | |
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APPLICATIONS |
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| Sulbactam, a derivative of the basic penicillin nucleus, is a beta-lactamase inhibitor. Chemical designation is (2S, 5R)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0] heptane-2-carboxylate 4,4-dioxide. It is used to increase the antibacterial spectrum of penicillins and cephalosporins against penicillinase-producing and beta-lactamase–producing organisms such as Staphylococcus aureus, H. flu, Moraxella catarrhalis that are resistant to ampicillin alone. Sulbactam does not improve enterococcal activity of ampicillin. Aampicillin/Gentamicin combination is used for the treatment of enterococcal infection. Sultamicillin is the combination of ampicillin and sulbactam. Sultamicillin is a white to off-white crystalline powder; soluble in aqueous diluents to yield reconstitution of ampicillin and sulbactam. Beta-lactamase enzymes are produced by some bacteria and have resistance ability to beta-lactam antibiotics. These enzymes deactivate the antibacterial properties of beta-lactam antibiotics by opening the beta-lactam ring. Beta-lactamase inhibitors have little antimicrobial functions themselves and are combined with an actual beta-lactam antibiotic. Beta-lactamase inhibitors' function is to bind beta-lactamase enzymes to form an inactive molecule so that the actual beta-lactam antibiotic access to the bacterial wall which it destroys. Beta-lactamase inhibitors include clavulanic acid, sulbactam, and tazobactam. | ||
| SALES SPECIFICATION | ||
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APPEARANCE |
white to off-white crystalline powder | |
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ASSAY |
97.0 - 103.0% |
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OPTICAL ROTATION |
+242° ~ +253° |
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WATER |
1.0% max |
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| TRANSPORTATION | ||
| PACKING |
5kgs
in drum
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