SULFAMETHIZOLE

PRODUCT IDENTIFICATION
CAS NO. 144-82-1

SULFAMETHIZOLE

EINECS NO. 205-641-1
FORMULA C9H10N4O2S2
MOL WT. 270.32

H.S. CODE

  

TOXICITY

  
SYNONYMS 4-Amino-N-(5-methyl-1,3,4-thiadiazol-2-yl) Benzenesulfonimide;
2-(p-Aminobenzenesulfonamido)-5-methyl-1,3,4-thiadiazole; Sulfamethylthiadiazole; 2-Sulfanilamido-5-methyl-1,3,4-thiadiazole; 5-Methyl-2-sulfanilamido-1,3,4-thiadiazole; N1-(5-methyl-1,3,4-thiadiazol-2-yl) Sulfanilimide;
SMILES

 

CLASSIFICATION

  

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white to pale yellow crystalline powder
MELTING POINT 208 - 210 C
BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER Insoluble at pH 6.5, soluble at pH 7.5
pH  
VAPOR DENSITY

 

AUTOIGNITION  

REFRACTIVE INDEX

  
NFPA RATINGS  
FLASH POINT

 

STABILITY Stable under normal conditions.

APPLICATIONS
Sulfamethizole, a sulfa drug, is used as an antimicrobial agent by inhibiting bacterial growth and activity in the treatment of infections of mainly the urinary tract.

Sulfonamide is an organic sulfur compounds containing the radical -SO2NH2 (the amides of sulfonic acids). Its molecular structure is similar to p-Aminobenzoic acid (PABA) which is needed in bacteria organisms as a substrate of the enzyme dihydropteroate synthetase for the synthesis of tetrahydrofolic acid (THF). Sulfonamides, derived from chiefly sulfanilamide, are capable of interfering with the metabolic processes in bacteria that require PABA. They act as antimicrobial agents by inhibiting bacterial growth and activity and called sulfa drugs. They are used in the prevention and treatment of bacterial infections, diabetes mellitus, edema, hypertension, and gout. Sulfa drug includes;

  • Topical sulfonamides: sulfacetamide; silver sulfadiazine; mafenide; 
  • Rapidly absorbed and eliminated sulfonamides: sulfisoxazole diolamine; sulfadiazine; sulfamethoxazole;
  • Hydrophylic sulfonamides: phtalylsulfacetamide; phtalylsulfathiazole; sulfasalazine; sulfaguanidine;
  • Long lasting sulfonamides: sulfadoxine; 
  • Others: sulfamazole; sulfamazone; sulfametopirazine; sulfametoxypiridazine; sulfametrol; succinylsulfathiazole; 
SALES SPECIFICATION (BP/EP/USP)

APPEARANCE

 white to pale yellow crystalline powder

IDENTIFICATION

Complies

ASSAY

 99.0 - 101.0% (on dry basis)

LOSS ON DRYING

0.5% max

Fe

5 ppm max

HEAVY METALS

20ppm max
TRANSPORTATION
PACKING
25kgs in fiber drum
HAZARD CLASS  
UN NO.  

OTHER INFORMATION
Hazard Symbols: XI, Risk Phrases: 43, Safety Phrases: 36/37