SULFAMETHOXAZOLE

PRODUCT IDENTIFICATION
CAS NO. 723-46-6

SULFAMETHOXAZOLE

EINECS NO. 211-963-3
FORMULA C10H11N3O3S
MOL WT. 253.28

H.S. CODE

  

TOXICITY

  
SYNONYMS 4-Amino-N-(5-methyl-3-isoxazolyl)benzenesulfonamide;
(p-Aminophenylsulfonamido)-5-methylisoxazole; 3-Sulfanilamido-5-methylisoxazole; 5-Methyl-3-sulfanilamidoisoxazole; N1-(5-Methyl-3-isoxazolyl)sulfanilamide; N-(5-methyl-3-isoxazolyl)sulfanilamide; Sulfamethoxizole; Sulfamethylisoxazole;
SMILES

 

CLASSIFICATION

  

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white crystalline powder
MELTING POINT  
BOILING POINT

 

SPECIFIC GRAVITY

 

SOLUBILITY IN WATER  
pH  
VAPOR DENSITY

 

AUTOIGNITION

 

NFPA RATINGS

 

REFRACTIVE INDEX

 

FLASH POINT

 

STABILITY

Stable under ordinary conditions.

GENERAL  DESCRIPTION & APPLICATIONS
Sulfonamide is an organic sulfur compounds containing the radical -SO2NH2 (the amides of sulfonic acids). Its molecular structure is similar to p-Aminobenzoic acid (PABA) which is needed in bacteria organisms as a substrate of the enzyme dihydropteroate synthetase for the synthesis of tetrahydrofolic acid (THF). Sulfonamides, derived from chiefly sulfanilamide, are capable of interfering with the metabolic processes in bacteria that require PABA. They act as antimicrobial agents by inhibiting bacterial growth and activity and called sulfa drugs. They are used in the prevention and treatment of bacterial infections, diabetes mellitus, edema, hypertension, and gout. Sulfa drug includes;
  • Topical sulfonamides: sulfacetamide; silver sulfadiazine; mafenide; 
  • Rapidly absorbed and eliminated sulfonamides: sulfisoxazole diolamine; sulfadiazine; sulfamethoxazole;
  • Hydrophylic sulfonamides: phtalylsulfacetamide; phtalylsulfathiazole; sulfasalazine; sulfaguanidine;
  • Long lasting sulfonamides: sulfadoxine; 
  • Others: sulfamazole; sulfamazone; sulfametopirazine; sulfametoxypiridazine; sulfametrol; succinylsulfathiazole; 
 

Sulfamethoxazole is used particularly for the prophylaxis and treatment of acute urinary tract infections and of pyodermata and infections of wounds and soft tissues. It is usually used in combination with trimethoprim, a bacterial dihydrofolate reductase inhibitor sulfonamide drug in the ratio 5:1.  The trade names of the combined product are Bactrim and Septra. The chemical designation of trimethoprim is 5-[(3, 4, 5-trimethoxyphenyl)methyl]-2, 4-pyrimidine diamine. It is a white to yellowish compound with bitter taste.  Sulfamethoxazole is 4-amino-N-(5-methyl-3-isoxazolyl) benzenesulfonamide or (N1-(5-methyl-3-Isoxazolyl) Sulfanilamide).
SALES SPECIFICATION (BP/USP)

APPEARANCE

 white crystalline powder
IDENTIFICATION Complies

ASSAY

99.0 - 101.0% (on dry basis)
ACIDITY

0.3% max
LOSS ON DRYING

0.5% max

SULFATE

0.1% max

SOLUTION CLARITY

Y5, BY3 or GY5

HEAVY METALS

20ppm max
TRANSPORTATION
PACKING
25kgs in fiber drum
HAZARD CLASS  
UN NO.  
OTHER INFORMATION
Hazard Symbols: XI, Risk Phrases: 36/37/38-43, Safety Phrases: 26-36