SULFATHIAZOLE

PRODUCT IDENTIFICATION
CAS NO.

72-14-0

SULFATHIAZOLE
EINECS NO. 200-771-5
FORMULA C9H9N3O2S2
MOL WT.

255.31

H.S. CODE

 2935.00

TOXICITY

 
SYNONYMS

N1-(2-Thiazolyl)Sulfanil Amide; Thiazamide;

2-(p-Aminobenzenesulfonamido)thiazole; 2-Sulfanilamidothiazole; Amino-N-2-thiazolylbenzenesulfonamide; Benzenesulfonamide, 4-Amino-N-2-thiazolyl-; cibazol; N(sup1)-2-thiazoylsulfanilamide;

SMILES

 

CLASSIFICATION

  

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE White to yellowish crystalline powder
MELTING POINT 200 - 203 C
BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER 0.5 g/l at 25 C
pH  
VAPOR DENSITY  

AUTOIGNITION

 

NFPA RATINGS

 Health: 1; Flammability: 0; Reactivity: 0

REFRACTIVE INDEX

  
FLASH POINT  
STABILITY

Stable under ordinary conditions

GENERAL DESCRIPTION AND APPLICATIONS

Sulfonamide is an organic sulfur compounds containing the radical -SO2NH2 (the amides of sulfonic acids). Its molecular structure is similar to p-Aminobenzoic acid (PABA) which is needed in bacteria organisms as a substrate of the enzyme dihydropteroate synthetase for the synthesis of tetrahydrofolic acid (THF). Sulfonamides, derived from chiefly sulfanilamide, are capable of interfering with the metabolic processes in bacteria that require PABA. They act as antimicrobial agents by inhibiting bacterial growth and activity and called sulfa drugs. They are used in the prevention and treatment of bacterial infections, diabetes mellitus, edema, hypertension, and gout. Sulfa drug includes;

  • Topical sulfonamides: sulfacetamide; silver sulfadiazine; mafenide; 
  • Rapidly absorbed and eliminated sulfonamides: sulfisoxazole diolamine; sulfadiazine; sulfamethoxazole;
  • Hydrophylic sulfonamides: phtalylsulfacetamide; phtalylsulfathiazole; sulfasalazine; sulfaguanidine;
  • Long lasting sulfonamides: sulfadoxine; 
  • Others: sulfamazole; sulfamazone; sulfametopirazine; sulfametoxypiridazine; sulfametrol; succinylsulfathiazole; 
Sulfathiazole has been replaced by less toxic antibiotics or used in combination with others such as sulfabenzamide and sulfacetamide.
SALES SPECIFICATION (BP/USP)

APPEARANCE

 White to yellowish crystalline powder

IDENTITY

pass

ASSAY

99.0% min
MELTING POINT

200 - 203 C
LOSS ON DRYING

0.5% max
TRANSPORTATION
PACKING 25kgs in fiber drum
HAZARD CLASS  
UN NO.  
OTHER INFORMATION
Hazard Symbols: XI, Risk Phrases: 36/37/38, Safety Phrases: 26-36

GENERAL DESCRIPTION OF THIAZOLE

Thiazole is a heterocyclic organic compound that has a five-member ring molecular structure, C3H3NS, containing three carbon atoms, one sulphur atom, and one nitrogen atom. It is a clear to yellowish liquid with a pyridine like odor. It is soluble in alcohol and ether and slightly soluble in water. It is used as an intermediate for numerous of this compound to manufacture synthetic drugs, fungicides, dyes, rubber accelerators and other organic chemicals.