| CAS
NO |
76497-13-7
(Base)
83105-70-8 (Tosylate) |
|
| EINECS
NO. |
|
| FORMULA |
C25H30N4O9S2 |
| MOL
WT. |
594.65 |
|
H.S.
CODE
|
|
|
TOXICITY
|
|
| SYNONYMS |
Sulbactam-Ampicillin;
|
| (2S,
5R)-(3,3-dimethyl-4,4,7-trioxo-4-thia-1-azabicyclo[3.2.0]hept-2ylcarbonyloxy)methyl
(2S,5R,6R)-6-[(R)-2-Amino-2-phenylacetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo
[3.2.0]heptane-2-carboxylate;
Hydroxymethyl (+)-(2S, 5R,
6R)-6-[(R)-(2-amino-2-phenyl acetamido)]- 3,3-dimethyl-7-oxo-4-thia-1-azabicyclo
[3.2.0] heptan-2-carboxylate, (2S, 5R)-3,3-dimethyl-7-oxo-4- thia-1-azabicyclo
[3.2.0]
heptane-2-carboxylate 4,4-dioxide; UNASYN;
|
| SMILES |
|
|
CLASSIFICATION
|
|
|
PHYSICAL
AND CHEMICAL PROPERTIES
|
| PHYSICAL
STATE |
white to off-white crystalline
powder |
| MELTING
POINT |
|
| BOILING
POINT |
|
| SPECIFIC
GRAVITY |
|
| SOLUBILITY
IN WATER |
|
| pH |
|
| VAPOR
DENSITY |
|
|
REFRACTIVE
INDEX
|
|
|
NFPA
RATINGS
|
|
|
AUTOIGNITION
|
|
| FLASH
POINT |
|
| STABILITY |
Stable
under ordinary conditions. |
|
APPLICATIONS
|
| Sulbactam, a derivative of the basic penicillin nucleus, is a beta-lactamase
inhibitor. Chemical designation is (2S,
5R)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0] heptane-2-carboxylate
4,4-dioxide. It is used to increase the antibacterial spectrum of penicillins
and cephalosporins against penicillinase-producing and beta-lactamase–producing
organisms such as Staphylococcus aureus, H. flu, Moraxella catarrhalis that are
resistant to ampicillin alone. Sulbactam does not improve enterococcal activity of ampicillin.
Aampicillin/Gentamicin combination is used for the treatment
of enterococcal infection. Sultamicillin is the combination of ampicillin
and sulbactam. Sultamicillin is a white to off-white crystalline powder; soluble in aqueous
diluents to yield reconstitution of ampicillin and sulbactam. |
| SALES
SPECIFICATION |
|
Sultamicillin
Base |
|
APPEARANCE
|
white to off-white crystalline
powder |
|
ASSAY
|
96.0%
min
|
|
OPTICAL
ROTATION
|
+242°
~ +253°
|
|
HEAVY
METALS
|
20ppm
max
|
|
SULFATE
|
0.2%
max
|
|
FREE
IDENTITY
|
1.0%
max (Sulbactam)
3.0% max (Ampicillin)
|
|
WATER
|
1.0%
max
|
|
Sultamicillin
Tosylate Dihydrate |
|
APPEARANCE
|
white to off-white crystalline
powder |
|
IDENTIFICATION
|
Complies
|
|
ASSAY
(HPLC)
|
75.0
- 79.5%
|
|
RESIDUE
ON IGNITION
|
0.1%
max
|
|
PTSA
|
21.5
- 23.5% (p-Toluene Sulfonic acid)
|
|
SOLVENT
RESIDUE
|
2.0%
max (Isopropyl Alcohol)
2.0% max (Ethyl Acetate)
|
|
FREE
IDENTITY
|
1.0%
max (Sulbactam)
4.0% max (Ampicillin)
|
|
HEAVY
METALS
|
10ppm
max
|
|
WATER
|
4.0
- 6.0%
|
| TRANSPORTATION |
| PACKING |
5kgs
in drum
|
| HAZARD
CLASS |
|
| UN
NO. |
|
| OTHER
INFORMATION |
|
|