| Testosterone is the major androgenic hormone that is responsible for the growth
and development of masculine characteristics. It is produced in the Leydig cells
(interstitial cells) of the testes. it regulates gonadotropic secretion and
wolffian duct differentiation (formation of the epididymis, vas deferens, and
seminal vesicle), and stimulates skeletal muscle. It is also responsible for
other male characteristics and spermatogenesis after its conversion to
dihydrotestosterone by 5alpha-reductase in peripheral tissue.
Testosterone is converted to dihydrotestosterone in the target tissues where it
appears to mediate many of the biological actions of testosterone. In addition,
testosterone possesses protein anabolic properties, manifested by retention of
nitrogen, calcium, phosphorus, and potassium, and is important in maintaining
muscle mass and bone tissue in the adult male. It is also converted by
aromatization to estradiol in peripheral tissue. It has been synthesized for
replacement therapy, in the form of various esters having prolonged duration of
effects, in treating male hypogonadism, cryptorchidism, frigidity, inoperable
female breast cancer, oligospermia, to suppress lactation, and as an anabolic
agent. Esters administered by subcutaneous, intramuscular injection, buccally or
intramuscularly include;
· Cloxotestosterone (CAS
RN: 53608-96-1) · Ethisterone
(Ethynyl testosterone, CAS RN: 434-03-7) · Mestanolone
(CAS RN: 521-11-9) · 17alpha-Methyltestosterone (CAS RN: 58-18-4) · Norethindrone
(CAS RN: 68-22-4) · Normethisterone (CAS RN: 514-61-4) · Oxymetholone
(CAS RN: 434-07-1) · Silandrone (Testosterone trimethylsilyl ether,
CAS RN: 5055-42-5) · Testosterone Acetate (CAS RN: 1045-69-8) · Testosterone Phenylpropionate
(CAS RN: 1255-49-8) · Testosterone Benzoate (CAS RN: 2088-71-3) · Testosterone heptanoate
(CAS RN: 315-37-7) · Testosterone phenylacetate (CAS RN: 5704-03-0) · Testosterone propionate
(CAS RN: 57-85-2) · Testosterone cypionate (CAS RN: 58-20-8) · Testosterone ketolaurate
(CAS RN: 5874-98-6) · Testosterone Undecanoate · Testosterone
Glucuronide · Testosterone Hemisuccinate
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