TETRACYCLINE

TETRACYCLINE
PRODUCT IDENTIFICATION
CAS NO.	60-54-8 (anhydro) 6416-04-2 (trihydrate) 64-75-5 (hydrochloride)
EINECS NO.	200-481-9
FORMULA	C₂₂H₂₄N₂O₈
MOL WT.	444.44
H.S. CODE	2941.30.0000
TOXICITY
SYNONYMS	Achromycin; Cefracycline; Tetracyclinum; Polycycline;
Achromycin; Panmycin ; 4S-(4alpha,4aalpha,5aalpha,6beta,12aalpha))-4-(Dimethylamino)- 1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl- 1,11-dioxo-2- naphthacenecarboxamide; 6-Methyl-1,11-dioxy-2-naphthacenecarboxamide;
SMILES	C[C@]1(c2cccc(c2C(=O)C3=C([C@]4([C@@H](C[C@@H]31)[C@@H] (C(=C (C4=O)C(=O)N)O)N(C)C)O)O)O)O
CLASSIFICATION	Antibiotic, Antiamebic, Antibacterial, Antirickettsial
EXTRA NOTES	A naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis.[MeSH]
PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE	off-white powder
MELTING POINT	175 ~ 177 C
BOILING POINT
SPECIFIC GRAVITY
SOLUBILITY IN WATER	231 mg/l
pH
VAPOR DENSITY
AUTOIGNITION
NFPA RATINGS
REFRACTIVE INDEX
FLASH POINT
STABILITY	Stable under ordinary conditions
EXTERNAL LINKS & GENERAL DESCRIPTION
USA.gov - Tetracycline Wikipedia Linking - Tetracycline Google Scholar Search - Tetracycline U.S. National Library of Medicine - Tetracycline PubChem Compound Summary - Tetracycline Drug Bank - Tetracycline KEGG (Kyoto Encyclopedia of Genes and Genomes) - Tetracycline ChEBI (http://www.ebi.ac.uk/chebi/) - Tetracycline NCBI (http://www.ncbi.nlm.nih.gov/) - Tetracycline Human Metabolome Database - Tetracycline Hazardous Substances Data Bank - Tetracycline EPA - Substance Registry Services - Tetracycline http://www.sigmaaldrich.com/ Tetracyclines possess a wide range of antimicrobial activity against gram-positive and gram-negative bacteria. The bacterial ribosome is the site of action of tetracyclines. Access to the ribosomes of gramnegative bacteria is obtained by passive diffusion through hydrophilic pores in the outer cell membrane and then by an energy-dependent active transport system that pumps all tetracyclines through the inner cytoplasmic membrane. Local: Tetracycline is a member of the tetracycline family useful because of broad antimicrobial action. It is chiefly used in treating infections caused by streptococci, staphylococci, Gram-negative bacilli, rickettsiae, and certain protozoans and viruses. Tetracycline can be produced biosynthetically by fermentation with a strain of Streptomyces aureofaciens (or certain other species) or chemically by hydrogenolysis of chlortetracycline. Tetracyclines inhibit bacterial protein synthesis by binding to the 30S ribosomal subunit. tetracyclines act as a inhibitor of a growth (bacteriostatic) rather than killer of the infectious agent (bacteriocidal) and is only effective against multiplying microorganisms. Tetracycline antibiotics include; Chlortetracycline (CAS # : 57-62-5) Demeclocycline Hydrochloride (CAS # : 64-73-3) Demethylchlortetracycline (CAS # : 127-33-3) Dihydrostreptomycin Sesquisulfate (CAS # : 5490-27-7) Doxycycline (CAS # : 564-25-0) Duramycin (CAS # : 1391-36-2) Meclocycline Sulfosalicylate (CAS # : 73816-42-9) Methacycline Hydrochloride (CAS # : 3963-95-9) Minocycline (CAS # : 10118-90-8) Neomycin (CAS # : 1404-04-2) Oxytetracycline (CAS # : 6153-64-6) Streptomycin (CAS # : 57-92-1) Tetracycline (CAS # : 60-54-8) Vancomycin (CAS # : 123409-00-7)
SALES SPECIFICATION (USP/BP)
APPEARANCE	off-white powder
ASSAY	88.0% min
TRANSPORTATION
PACKING
HAZARD CLASS
UN NO.
SAFETY INFORMATION
HAZARD OVERVIEW	GHS (Globally Harmonised System) Classification: Acute toxicity (Oral). Hazard statements: Harmful if swallowed. Potential Health Effects: Eyes - May cause eye irritation. Skin - Harmful if absorbed through skin. May cause skin irritation. Ingestion - Harmful if swallowed. Inhalation - May be harmful if inhaled. May cause respiratory tract irritation.
GHS
SIGNAL WORD	Warning
PICTOGRAMS
HAZARD STATEMENTS	H302
P STATEMENTS	P264-P270-P301 + P312-P330-P501
EC DIRECTIVES
HAZARD CODES
RISK PHRASES	22
SAFETY PHRASES	22-36
PRICE INFORMATION