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| TRIMETHOPRIM | ||
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PRODUCT IDENTIFICATION |
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| CAS NO. | 738-70-5 |
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| EINECS NO. | 212-006-2 | |
| FORMULA | C14H18N4O3 | |
| MOL WT. | 290.32 | |
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H.S. CODE |
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TOXICITY |
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| SYNONYMS | Chemotrim; Idotrim; | |
| Monotrim; Primosept; Primsol; Proloprim; 2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine; Lidaprim; Methoprim; 5-((3,4,5-Trimethoxyphenyl)methyl)-2,4-pyrimidinediamine; Syraprim; Tiempe; TMP-Ratiopharm; Trimanyl; Trimethoprim; Trimexazole; Trimogal; Trimetoprima; 5-(3,4,5-trimetoxibencil)pirimidina-2,4-diamina (Spanish); Triméthoprime; 5-(3,4,5-triméthoxybenzyl)pyrimidine-2,4-diamine (French); 5-(3,4,5-Trimethoxybenzyl)-2,4- DiaminoPyrimidine; 5-(3,4,5-Trimethoxybenzyl) pyrimidin-2,4-diamin (German); | ||
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CLASSIFICATION |
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PHYSICAL AND CHEMICAL PROPERTIES |
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| PHYSICAL STATE | white to yellowish powder | |
| MELTING POINT | 199 - 203 C | |
| BOILING POINT | ||
| SPECIFIC GRAVITY | ||
| SOLUBILITY IN WATER | (Soluble in DMSO) | |
| pH | ||
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AUTOIGNITION |
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NFPA RATINGS |
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REFRACTIVE INDEX |
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| FLASH POINT | ||
| STABILITY |
Stable under ordinary conditions | |
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GENERAL DESCRIPTION AND APPLICATIONS |
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| Trimethoprim, an antibacterial drug, is a bacterial dihydrofolate reductase inhibitor used as a prophylactic or to treat various bacterial infections particularly urinary tract infections such as Proteus mirabilis, Escherichia coli, and Klebsiella species as well as Pneumocystis carinii and traveler's diarrhea. Folic acid is essential for hematopoiesis. It is reduced to dihydrofolic acid and then tetrahydrofolic acid , the parent compound of the derivatives that act as coenzyme carriers of one-carbon groups in various metabolic reactions. In result, trimethoprim interferes the synthesis of tetrahydrofolic acid resulting the inhibition of the DNA nucleoside synthesis. It is usually used in combination with a sulfonamide drug, sulfamethoxazole for synergistic effect (in the ratio 1:5). The molecular structure of sulfonamide class antimicrobial agents is similar to p-Aminobenzoic acid (PABA) which is needed in bacteria organisms as a substrate of the enzyme dihydropteroate synthetase for the synthesis of tetrahydrofolic acid (THF). Sulfonamides are capable of interfering with the metabolic processes in bacteria that require PABA. The combination drug interferes with sequential steps in the metabolism of certain bacteria. But the use of sulfamethoxazole is declining due to reports of sulfamethoxazole bone marrow toxicity. The trade names of the combined product are Bactrim and Septra. The chemical designation of trimethoprim is 5-[(3, 4, 5-trimethoxyphenyl)methyl]-2, 4-pyrimidine diamine. It is a white to yellowish compound with bitter taste. Sulfamethoxazole is 4-amino-N-(5-methyl-3-isoxazolyl) benzenesulfonamide or (N1-(5-methyl-3-Isoxazolyl) Sulfanilamide). It is an white to off-white compound, odorless, tasteless. Dapsone (4,4'-sulfonylbisbenzenamine) is a parent compound in preparing sulfonamide antibacterial agents such as acedapsone, acetosulfone, glucosulfone, sulfoxone and solapsone. Dapsone and its derivatives have bacteriostatic activity against a broad spectrum of gram-negative and gram-positive organisms. Dapsone is a primary treatment for Dermatitis herpetiformis and in the treatment of leprosy (Mycobacterium leprae infections) leads to apparent improvementas. It is used in the prophylaxis of falciparum malaria. It is a white crystalline powder; melting point 175 - 180C; insoluble in water and vegetable oils. Pentamidine is also used for the patients who are allergic to trimethoprim or sulfamethoxazole. Pentamidine is an antiprotozoal agent used as the isethionate salt to preventi and treat diverse phylum of eukaryotic microorganisms. It is a nonpyrogenic, lyophilized product. Pentamidine isethionate is a white crystalline powder; soluble in water and glycerin; insoluble in ether, acetone, and chloroform. The chemical designation is 4,4'- diamidino-diphenoxypentane di(beta-hydroxyethanesulfonate). | ||
| SALES SPECIFICATION | ||
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BP/EP/CP/USP |
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APPEARANCE |
white to yellowish powder | |
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ASSAY |
99.0 - 101.0% |
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LOSS ON DRYING |
0.5% max |
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RELATED SUBSTANCE |
0.2% max |
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PARTICLE SIZE |
80 - 100 (mesh) |
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| TRANSPORTATION | ||
| PACKING | 25kgs in fiber drum | |
| HAZARD CLASS | ||
| UN NO. | ||
| OTHER INFORMATION | ||
| Hazard Symbols: T, Risk Phrases: 25, Safety Phrases: 45 | ||
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