VENLAFAXINE HYDROCHLORIDE

VENLAFAXINE HYDROCHLORIDE

PRODUCT IDENTIFICATION

CAS NO.

99300-78-4

VENLAFAXINE HYDROCHLORIDE

EINECS NO.

FORMULA C₁₇H₂₇NO₂·HCl

MOL WT. 313.87

H.S. CODE

TOXICITY

SYNONYMS Effexor;

(+/-)-1-(alpha-((dimethylamino)methyl)-p-methoxybenzyl)cyclohexanol hydrochloride; (RS)-1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol hydrochloride;

SMILES

CLASSIFICATION

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white crystalline powder

MELTING POINT 215 - 217 C

BOILING POINT

SPECIFIC GRAVITY

SOLUBILITY IN WATER Soluble

VAPOR DENSITY

AUTOIGNITION

NFPA RATINGS

REFRACTIVE INDEX

FLASH POINT

STABILITY

Stable under ordinary conditions

APPLICATIONS

Venlafaxine is an antidepressant structurally unrelated chemically to any other antidepressants. It inhibits both serotonin and norepinephrine reuptake. It is also used to treat OCD ( obsessive-compulsive disorder ) or FMS (Fibromyalgia). The hydrochloride samlt of venlafaxine is a a white to off-white crystalline powder; melting point 215 - 217 C; soluble in water; administered orally. The chemical designation is (+/-)-1-(alpha-((dimethylamino)methyl)-p-methoxybenzyl)cyclohexanol hydrochloride.

SSRIs are used to treat depressions and effective for obsessive-compulsive disorder, posttraumatic stress disorder, premenstrual dysphoric mood disorder, panic disorder, generalized anxiety disorder, and bulimia. Drugs used to treat depressions include;

TRICYCLIC ANTIDEPRESSANTS

Amitriptyline [CAS #: 50-48-6, 549-18-8 (HCl)]

Amoxapine [CAS #: 14028-44-5]

Clomipramine [CAS #: 303-49-1]

Desipramine [CAS #: 50-47-5 58-28-6 (HCl)]

Doxepin [CAS #: 1668-19-5, 1229-29-4 (HCl)]
Imipramine [CAS #: 50-49-7, 113-52-0 (HCl)]
Nortriptyline [CAS #: 894-71-3 (HCl)]
Protriptyline [CAS #: 438-60-8, 1225-55-4(HCl)]
Trimipramine [CAS #: 739-71-9, 521-78-8 (Maleate)]

TETRACYCLIC ANTIDEPRESSANT
- Maprotiline [CAS #: 10262-69-8, 10347-81-6 (HCl)]

MONOAMINE OXIDASE INHIBITORS
- Isocarboxazid [CAS #: 59-63-2, 24631-64-9 (Sulfate)]
- Phenelzine [CAS #: 51-71-8, 156-51-4 (Sulfate)]
- Tranylcypromine [CAS #: 155-09-9]

SELECTIVE SEROTONIN REUPTAKE INHIBITORS
- Fluoxetine [CAS #: 54910-89-3, 59333-67-4 (HCl)]
- Paroxetine [CAS #: 61869-08-7]
- Sertraline [CAS #: 79617-96-2, 79559-97-0 (HCl)]
- Escitalopram Oxalate [CAS #: 128196-01-0]
- Citalopram [CAS #: 59729-33-8, 59729-33-8 (HBr)]
- Fluvoxamine [CAS #: 54739-18-3, 6387-89-9 (Maleate)]

SEROTONIN-NOREPINEPHRINE REUPTAKE INHIBITOR
- Duloxetine [CAS #: 116539-59-4]

PSYCHOSTIMULANTS

Dextroamphetamine [CAS #: 51-64-9, 51-63-8 (Sulfate)]
Methylphenidate [CAS #: 113-45-1, 298-59-9 (HCl)]

MODIFIED ANTIDEPRESSANTS
- Trazodone [CAS #: 19794-93-5, 25332-39-2 (HCl)]
- Venlafaxine [CAS #: 93413-69-5, 99300-78-4 (HCl)]
- Nefazodone [CAS #: 83366-66-9]
- Mirtazapine [CAS #: 61337-67-5]
- Bupropion [CAS #: 31677-93-7]
- Buspirone [CAS #: 36505-84-7]
- Reboxetine [CAS #: 71620-89-8]

SALES SPECIFICATION

APPEARANCE

white crystals

IDENTIFICATION

Complies Test A,B

ASSAY

99.0% min

LOSS ON DRYING

1.0% max

RELATED SUBSTANCE

0.5% max

HEAVY METALS

20ppm max

SULFATED ASH

0.1% max

TRANSPORTATION

PACKING

HAZARD CLASS

UN NO.

OTHER INFORMATION

Hazard Symbols: n/a, Risk Phrases: 42/43, Safety Phrases:22-36/37-45

PRICES