ADEMETIONINE

PRODUCT IDENTIFICATION
CAS NO. 17176-17-9 (DL-form)
29908-03-0 (L-form)

 

EINECS NO.

249-946-8

FORMULA C15H22N6O5S
MOL WT. 398.44

H.S. CODE

 2934.99.9000

TOXICITY

  
SYNONYMS Ademetionine; S-Adenosylmethionine;
(±)-5'-((R')-((R')-3-Amino-3-carboxypropyl)methylsulfonio)-5'-deoxyadenosine hydroxide inner salt; S-Adenosyl-L-methionine; S-Adenosyl-L-methionine; AdoMet; SAMe; S-(5'-Adenosyl)-L-methionine; SAM;
SMILES C([C@@H]1[C@@H](O)[C@H]([C@@H](O1)n1cnc2c(N)ncnc12)O) [S+](C)CCC(C(=O)[O-])N

CLASSIFICATION

Coenzyme

EXTRA NOTES

 anti-apoptotic in normal hepatocytes and normal colon epithelial cells but pro-apoptotic in liver human hepatocellular carcinoma (HCC), HepG2 cells and colon cancer cells.

PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE white crystalline powder
MELTING POINT  
BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER  
pH  
VAPOR DENSITY

 

AUTOIGNITION

 

NFPA RATINGS

Health: 1, Flammability: 0, Reactivity: 0

REFRACTIVE INDEX

  
FLASH POINT

 

STABILITY Stable under ordinary conditions.

EXTERNAL LINKS & GENERAL DESCRIPTION

Wikipedia Linking

Google Scholar Search

Drug Information Portal (U.S. National Library of Medicine) - S-Adenosylmethionine

PubChem Compound Summary - S-Adenosylmethionine

Drug Bank -

KEGG (Kyoto Encyclopedia of Genes and Genomes) -  S-Adenosylmethionine

http://www.umm.edu/
S-Adenosylmethionine (SAMe) is a naturally occurring compound that is found in almost every tissue and fluid in the body. It is involved in many important processes. SAMe plays a role in the immune system, maintains cell membranes, and helps produce and break down brain chemicals, such as serotonin, melatonin, and dopamine. It works with vitamin B12 and folate (vitamin B6). Being deficient in either vitamin B12 or folate may reduce levels of SAMe in your body. Numerous scientific studies have shown that SAMe helps relieve the pain of osteoarthritis, and other studies suggest that SAMe may help treat depression. Researchers have also examined SAMe's use in the treatment of fibromyalgia and liver disease, with mixed results. Many of the early studies used SAMe given intravenously or as an injection. Only recently have researchers been able to look at the effects of SAMe taken by mouth.

http://academics.keene.edu/
Molecule of the Week: S-Adenosyl Methionine - Sometimes referred to as the "biological equivalent of methyl iodide," S-Adenosyl Methionine (or SAM, to its friends) carries out the methylation of members of most families of biomolecules. For example, bases in DNA and RNA are methylated as part of the maturation of the genetic material; protein amino groups are methylated, sugars are methylated on oxygen, and ethanolamine is converted to choline in the biosynthesis of phospholipids.

http://www.mbhs.org/
S-adenosylmethionine is quite a mouthful; the abbreviation SAMe (pronounced samm-ee ) is easier to say. Its chemical structure and name are derived from two materials you may have heard about already: methionine, a sulfur-containing amino acid; and adenosine triphosphate (ATP), the body's main energy molecule. SAMe was discovered in Italy in 1952. It was first investigated as a treatment for depression, but along the way it was accidentally noted to improve arthritis symptoms—a kind of positive side effect

 
SALES SPECIFICATION (SAMe-Disulfate Tosylate CAS RN.: 97540-22-2)

APPEARANCE

 white crystalline powder, hygroscopic

TOTAL CONTENT

 95.0% min (HPLC), on the dried basis

ADEMETIONINE ION

48.0% - 52.0%

(S.S)-ISOMER

75.0% min

WATER

2.5% max

pH

1.0 - 2.0

RELATED SUBSTANCES

1.5% max

HEAVY METALS

10ppm max
TOTAL PLATE COUNT

100 cfu/g max
SALES SPECIFICATION (SAMe-1,4-Butanedisulfonate CAS RN.: 101020-79-5)

APPEARANCE

 white crystalline powder, hygroscopic

TOTAL CONTENT

 95.0% min (HPLC), on the dried basis

ADEMETIONINE ION

49.0% - 53.0%

(S.S)-ISOMER

60.0% min

WATER

2.5% max

pH

3.0 - 4.0

RELATED SUBSTANCES

1.5% max

HEAVY METALS

10ppm max
TOTAL PLATE COUNT

100 cfu/g max
TRANSPORTATION
PACKING

 

HAZARD CLASS  
UN NO. Not regulated
SAFETY INFORMATION

Hazard OVERVIEW

Not known

GHS

 
SIGNAL WORD  

PICTOGRAMS

None

HAZARD STATEMENTS

H303 May be harmful if swallowed.
EC DIRECTIVES

 
HAZARD CODES

 

RISK PHRASES

36/37/38 Irritating to eyes, respiratory system and skin

SAFETY PHRASES

24/25 Avoid contact with skin and eyes

PRICE INFORMATION