ALLOXAN MONOHYDRATE

PRODUCT IDENTIFICATION

CAS NO. 50-71-5 (base), 2244-11-3 (monohydrate)

ALLOXAN

EINECS NO. 200-062-0
FORMULA C4H2N2O4·H2O
MOL WT. 160.08

H.S. CODE

 

TOXICITY

 
SYNONYMS
2,4,5,6-Pyrimidintetron; Alloxane  monohydrate;
2,4,5,6(1H,3H)-Pyrimidinetetrone hydrate; 2,4,5,6-Tetraoxohexahydropyrimidine hydrate; 2,4,5,6(1H,3H)-Pyrimidinetetrone, monohydrate; 5-Oxobarbituric acid monohydrate; Mesoxalylcarbamide monohydrate; Mesoxalylurea monohydrate; 5,6-Dioxyuracil monohydrate;
DERIVATION

 

CLASSIFICATION

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white powder
MELTING POINT 255 C (Decomposes)
BOILING POINT  
SPECIFIC GRAVITY

 

SOLUBILITY IN WATER

 

pH  
VAPOR DENSITY

 

AUTOIGNITION

 

NFPA RATINGS  

REFRACTIVE INDEX

 
FLASH POINT

 

STABILITY

Stable under ordinary conditions

GENERAL DESCRIPTION & APPLICATIONS

Allantoin, the diureide of glyoxylic acid, is a crystallizable oxidation product of uric acid found in allantoic and amniotic fluids, in fetal urine and in many plants. (Ureide is a compound derived from urea and contains acid radicles. Those from one molecule of urea, as alloxan, are monoureides; those derived from two, as uric acid, are diureides). Allantoin is an urinary excretion product of purine metabolism in most mammals but not in higher apes including humans. It is produced synthetically by the oxidation of uric acid. Allantoin is active in skin-softening (keratolytic effect) and rapid cell regeneration by precipitating proteins on skin. It is used as an abrasive and astringent agent in the end products include cosmetic lotions, creams, suntan products, scalp preparations, shampoos , lipsticks and and various aerosol preparations. It is used in topical pharmaceutical preparations. Allantoin has been used in various oral hygeine preparations such as toothpaste and mouthwash as well as in  eye drops to treat watering eyes and in ear drops to clean the ear canal. Alloxan is an oxidized product of uric acid by nitric acid. When administered to experimental animals, it produces selective destruction of the beta cells of the pancreas, causing hyperglycemia and ketoacidosis. Alloxan, a strong oxidizing agent, and its reduced product dialuric acid  form alloxantin (a hemiacetal) which is used as a raw material to produce ammonium purpurate dye, murexide (C8H5N5O6·NH3) with heating at 100 C in ammonia gas. Murexide is used as a complexometric titration indicator and as a colorimetric reagent for measurement of calcium and rare earth metals.

Product

CAS RN.

Alloxan 50-71-5
Alloxantin 76-24-4
Violuric acid 87-39-8
Alloxanic acid 470-44-0

Violuric acid monosodium salt

825-29-6

Alloxan monohydrate 2244-11-3
Oxypurinol 2465-59-0
1,3-Dimethylalloxan 2757-85-9
2,4,5,6(1H,3H)-Pyrimidinetetrone hydrate 3237-50-1
Alloxanthin 28380-31-6
5-((4-Methoxy-2-nitrophenyl)hydrazone) alloxan 31353-87-4
1-Phenylvioluric acid 82628-28-2
SALES SPECIFICATION

APPEARANCE

white crystalline powder

ASSAY

98.5% min

MELTING POINT

255 C

TRANSPORTATION
PACKING
 
HAZARD CLASS  
UN NO.  
OTHER INFORMATION
Hazard Symbols: XN, Risk Phrases: 20/21/22, Safety Phrases: 36