ALTRETAMINE

Synonyms. Altretamine; 2,4,6-Tris(dimethylamino)-1,3,5-triazine; Hexamethylmelamine; N,N,N',N',N'',N''-Hexamethyl-1,3,5-triazine-2,4,6-triamine; 2,4,6-Tris(dimethylamino)-s-triazine; Altretamina; Altretaminum; Hexalen; Hemel;

ALTRETAMINE

Click for original image

 

PRODUCT IDENTIFICATION

CAS RN

645-05-6

EINECS RN

211-428-4

FORMULA

 C9H18N6

MOLE WEIGHT

210.28

H.S CODE

 2933.69.6050

SMILES

 c1(nc(nc(n1)N(C)C)N(C)C)N(C)C

CLASSIFICATION

Insect attractant, Alkylating agent, Antineoplastic, Triazine

EXTRA NOTES

 An alkylating agent proposed as an antineoplastic. It also acts as a chemosterilant for male houseflies and other insects.

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE.

white to off-white crystalline powder

MELTING POINT

171 ~ 175 C

BOILING POINT

 

DENSITY

 

SOLUBILITY IN WATER

91mg/l

SOLVENT SOLUBILITY  

VAPOR DENSITY

 

log P(octanol-water)

 2.73

VAPOR PRESSURE

  

AUTOIGNITION TEMP

  
pH

 

REFRACTIVE INDEX

 

FLASH POINT

 

 
STABILITY AND REACTIVITY
STABILITY Stable under normal conditions.

INCOMPATIBLE MATERIALS

Strong oxidizing agents.

POLYMERIZATION

Has not been reported

NFPA RATINGS

Health: 2, Flammability: 0, Reactivity: 0

 

EXTERNAL LINKS & GENERAL DESCRIPTION

Wikipedia Linking - Altretamine

Google Scholar Search - Altretamine

Drug Information Portal (U.S. National Library of Medicine) - Altretamine

PubChem Compound Summary - Altretamine

Drug Bank -  Altretamine

KEGG (Kyoto Encyclopedia of Genes and Genomes) - Altretamine

http://www.ebi.ac.uk/ - Altretamine

http://www.ncbi.nlm.nih.gov/ - Altretamine

http://toxnet.nlm.nih.gov/
Hazardous Substances Data Bank - Altretamine

http://www.cancer.gov
A synthetic cytotoxic s-triazine derivative similar in structure to alkylating agent triethylenemelamin with antineoplastic activity. Although the precise mechanism by which altretamine exerts its cytotoxic effect is unknown, N-demethylation of altretamine may produce reactive intermediates which covalently bind to DNA, resulting in DNA damage.

 

SALES SPECIFICATION

APPEARANCE

white to off-white crystalline powder

IDENTIFICATION

positive (Test A,B)

ASSAY

98.0% ~ 102.0% (on anhydrous basis)

MELTING POINT

171 ~ 175 C
LOSS ON DRYING

1.0% max

HEAVY METALS

10ppm max
RESIDUE ON IGNITION

0.2% max

 

TRANSPORT & REGULATORY INFORMATION

UN NO.

Not regulated

HAZARD CLASS

  
PACKING GROUP  

 

SAFETY INFORMATION

HAZARD OVERVIEW

Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. OSHA Hazards:Target Organ Effect, Toxic by ingestion, Irritant. Target Organs:Central nervous system

GHS

  

SIGNAL WORD

Warning

PICTOGRAMS

HAZARD STATEMENTS

H302-H315-H319-H335

P STATEMENTS

P261-P305 + P351 + P338

EC DIRECTIVES

 

HAZARD CODES

Xn

RISK PHRASES

22-36/37/38

SAFETY PHRASES

 26-36

 

PACKING

Preserve in light-resistant and well-closed containers