AZELASTINE HYDROCHLORIDE

PRODUCT IDENTIFICATION
CAS NO. 58581-89-8 (Parent), 79307-93-0 (HCl)

AZELASTINE HYDROCHLORIDE

EINECS NO. 200-306-6
FORMULA C22H24ClN3O·HCl
MOL WT. 418.36

H.S. CODE

  

TOXICITY

 
SYNONYMS Astelin; Azeptin; Optivar;
4-(p-Chlorobenzyl)-2-(hexahydro-1-methyl-1H-azepin-4-yl)-1(2H)-phthalazinone monohydrochloride; 4-((4-Chlorophenyl)methyl)-2-(hexahydro-1-methyl-1H-azepin-4-yl)-1(2H)-phthalazinone hydrochloride;
DERIVATION  

CLASSIFICATION

  

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white crystalline powder
MELTING POINT 223 - 228 C
BOILING POINT

 
SPECIFIC GRAVITY  
SOLUBILITY IN WATER 13 g/l at 20 C (insoluble in ethanol, ether)
pH  
VAPOR DENSITY

 

AUTOIGNITION

 

NFPA RATINGS

 Health: 1; Flammability: 0; Reactivity: 0

REFRACTIVE INDEX

  
FLASH POINT

 

STABILITY

Stable under ordinary conditions

GENERAL DESCRIPTION & APPLICATIONS

Azelastine is an antihistamine for the biological ant-allergic action to cause the symptoms of the hypersensitive and in treatment of hay fever. It belongs to H1 receptor antagonists which block the H1 type of receptors, which are involved in allergic reactions. Azelastine is used to treat allergic symptoms that may underlie the chronic inflammation  as an anti-asthmatic agent. Azelastine is used intranasally as the hydrochloride salt form, white crystalline powder; sparingly soluble in water, methanol, and propylene glycol and slightly soluble in ethanol, octanol, and glycerine.

SALES SPECIFICATION

APPEARANCE

 white crystalline powder

ASSAY

98.5% min
LOSS ON DRYING 0.5% max
RESIDUE ON IGNITION 0.1% max
HEAVY METAL 10ppm max
pH 4.8 - 6.8
MELTING POINT 223 - 228 C
TRANSPORTATION
PACKING
 
HAZARD CLASS  
UN NO.  
OTHER INFORMATION