PRODUCT IDENTIFICATION
H.S. CODE
TOXICITY
CLASSIFICATION
PHYSICAL AND CHEMICAL PROPERTIES
REFRACTIVE INDEX
NFPA RATINGS
AUTOIGNITION
FLASH POINT
GENERAL DESCRIPTION & APPLICATIONS
Bicalutamide is capable of inhibiting the biological effects of male sex hormones (androgens). Antiandrogens are sometimes used in the treatment of prostate cancer. Bicalutamide is used for therapy of prostatic carcinoma, in combination with measures to lower testosterone levels; administered orally. Only R-enantiomer of bicalutamide is antiandrogenically active; the S-enantiomer is inactive. But commercial bicalutamide is a racemate. The chemical designation is N-[4-cyano-3-(trifluoromethyl)phenyl]- 3-(4-fluorophenyl)sulfonyl-2- hydroxy-2-methyl- propanamide. Bicalutamide is a white to off-white powder, practically insoluble in water.
Antiandrogens
|
Antiandrogen |
CAS RN |
| 1,6,10-Trihydroxy-2-(hydroxymethyl)-8,10-dimethyl-9(10H)-anthracenone | 154163-90-3 |
| 1,6,10-Trihydroxy-2,8,10-trimethyl-9(10H)-anthracenone | 154163-89-0 |
| 15-Hydroxycyproterone acetate | 114884-50-3 |
| 17,17-Dimethyl-18-norandrosta-4,13-dien-3-one | 1971-59-1 |
| 17beta-Hydroxy-2alpha,2beta,17alpha-trimethyl-8alpha-estra-4,9,11- trien-3-one | 42438-88-0 |
| 17-Hydroxycyproterone acetate | 65423-26-9 |
| 17-N,N-Diethylcarbamoyl-4-methyl-4-azaandrostane-3-one | 73671-86-0 |
| 2,2,4,6,6,8-Hexamethyl-4,8-diphenylcyclotetrasiloxane | 4657-20-9 |
| 2',3alpha'-Tetrahydrofuran-2'-spiro-17-(6alpha,7alpha-difluoromethylene- 1alpha,2alpha -methylene)-4-androsten-3-one | 57129-44-9 |
| 2-Azachlormadinone acetate | 105165-23-9 |
| 3-(Cyclohex-3-en-1-on-4-yl)-4-(4-hydroxyphenyl)hexane | 129579-58-4 |
| 3-alpha-Hydroxy-cyproterone acetate | 167356-55-0 |
| 3-Chloro-4-(2-amino-3-chlorophenyl)pyrrole | 16386-65-5 |
| 4-(3,4,4-Trimethyl-5-oxo-2-thioxo-1-imidazolidinyl)-2-(trifluoromethyl) benzonitrile | 143782-25-6 |
| 4-(4,4-Dimethyl-2,5-dioxo-3-(4-hydroxybutyl)-1-imidazolidinyl)- 2-(trifluoromethyl)benzonitrile | 154992-24-2 |
| 4-(4,4-Dimethyl-3-(4-hydroxybutyl)-5-oxo-2-thioxo-1-imidazolidinyl)- 2-(trifluoromethyl)benzonitrile | 155180-53-3 |
| 4,5-Secodihydrotestosterone | 76760-84-4 |
| 4,6-Estradiene-3,17-dione | 13209-45-5 |
| 6,7-Epoxycyproterone acetate | 148749-29-5 |
| 6,7-Epoxy-cyproterone acetate | 40007-74-7 |
| 6-alpha-Bromo-17-beta-hydroxy-17-alpha-methyl-4-oxa-5-alpha- androstan-3-one | 24543-59-7 |
| 7-Acetyl-4,4a,4b,5,6,7,8,8a,9,10-decahydro-2(3H)-phenanthrone | 2327-61-9 |
| 7alpha-(Methylthio)spironolactone S-oxide | 38753-75-2 |
| 7alpha-Thiospironolactone | 38753-76-3 |
| 7-Thiomethylspirolactone | 38753-77-4 |
| Anthrasteroid 1 | 120542-29-2 |
| Anthrasteroid 2 | 120542-30-5 |
| Benorterone | 3570-10-3 |
| Bicalutamide | 90357-06-5 |
| Cioteronel | 89672-11-7 |
| Cyoctol | 105635-64-1 |
| Cyproterone | 2098-66-0 |
| Cyproterone acetate | 427-51-0 |
| Delmadinone | 15262-77-8 |
| Delmadinone acetate | 13698-49-2 |
| Diane | 60528-19-0 |
| Dutasteride | 164656-23-9 |
| Edogestrone | 809-01-8 |
| Finasteride | 98319-26-7 |
| Flutamide | 13311-84-7 |
| Hydroxyflutamide | 52806-53-8 |
| Inocoterone acetate | 83646-86-0 |
| Ketoconazole | 65277-42-1 |
| Liarozole | 115575-11-6 |
| Methyl 3-oxo-4-methyl-4-aza-5alpha-androst-1-ene-17beta-carboxylate | 103335-44-0 |
| Mifentidine | 83184-43-4 |
| N-(2-Chloromethyl-2-hydroxypropionyl)-3,4,5-trichloroaniline | 65372-80-7 |
| N-(3,5-Dimethyl-4-isoxazolylmethyl)phthalimide | 39962-28-2 |
| Nilutamide | 63612-50-0 |
| Nordinone | 33122-60-0 |
| Osaterone acetate ester | 105149-00-6 |
| Oxendolone | 33765-68-3 |
| Oxyma | 57361-81-6 |
| Pleconaril | 153168-05-9 |
| Spironolactone | 52-01-7 |
| Topterone | 60607-35-4 |
| Vinclozolin | 50471-44-8 |
| Zanoterone | 107000-34-0 |
APPEARANCE
PURITY
99.0% min
INDIVIDUAL IMPURITY
0.1% max
TOTAL IMPURITY
0.5% max
HEAVY METALS
20ppm max
0.1% max
1.000ppm max
| Bacteria | 1000 cfu/g max |
| Fungi | 100 cfu/g max |
| Escherichia coli | absent |
| Salmonella | absent |
| Staphylococcus aureus | absent |
| Pseudomonas aeruginosa | absent |