BISMUTH SUBSALICYLATE

PRODUCT IDENTIFICATION
CAS NO.

14882-18-9

BISMUTH SUBSALICYLATE

EINECS NO. 238-953-1
FORMULA HOC6H4COOBiO
MOL WT. 362.09

H.S. CODE

  

TOXICITY

  
SYNONYMS 2-Hydroxybenzoic acid bismuth (3+) salt;
Basic bismuth salicylate; Bismuth oxysalicylate; Bismuth salicylate, basic; (2-Hydroxybenzoato-O(1),O(2))oxobismuth; Oxo(salicylato)bismuth; Bismuthi subsalicylas; Bismutum subsalicylicum; Salicylic acid basic bismuth salt; Spiromak forte; Stabisol; Vismut; Wismutsalicylat, basisches; Wismutsubsalicylat; (2-Hydroxybenzoato-O(1))-oxobismuth; Bismuth oxide salicylate; Other CAS RN.: 87-27-4; 8045-18-9; 55200-42-5; 56029-89-1; 61529-49-5;
DERIVATION

 

CLASSIFICATION

  

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white to off-white crystalline powder
MELTING POINT >350 C
BOILING POINT

 

SPECIFIC GRAVITY  
SOLUBILITY IN WATER Insoluble
pH  
VAPOR DENSITY

 

REFRACTIVE INDEX

 

NFPA RATINGS

  

AUTOIGNITION

 

FLASH POINT

 

STABILITY Stable under normal conditions.

GENERAL DESCRIPTION & APPLICATIONS

Bismuth subsalicylate, a bismuth salt of salicylic acid, is the active ingredient in popular medication Pepto-Bismol (a non-aspirin salicylate medication produced by the Procter and Gamble) and Kaopectate from Chattem, Inc. It is used as an antidiarrheal and in the treatment of gastric distress, including nausea, indigestion, and heartburn; administered orally. It acts as an anti-inflammatory or mild antibiotic. It displays also an antacid action which counteracts or neutralizes acidity, usually of the stomach. Some examples of antacid and antidiarrheal ingredients include:

Antacid

CAS RN.
Sodium bicarbonate 144-55-8

Calcium carbonate [USAN]

471-34-1
Bismuth subnitrate [USAN:JAN] 1304-85-4
Magnesium hydroxide [JAN] 1309-42-8
Magnesium oxide [JAN] 1309-48-4
Magaldrate 1317-26-6
Aluminum magnesium silicate 1327-43-1
Algeldrate [USAN:INN] 1330-44-5
beta-Dimethylaminoethyl-alpha,alpha-diphenyl-alpha-propargoxyacetate 2765-97-1
Aldioxa [USAN:INN:JAN] 5579-81-7
6-Aminoindazole 6967-12-0
Bismuth 7440-69-9
Aluminum phosphate 7784-30-7
Almagel-neo 8065-58-5
Combinationture (Aluminum hydroxide, magnesium silicon oxide) 8077-28-9
Polyethadene [USAN] 9003-23-0
Magnesium phosphate [USAN] 10233-87-1
Dihydroxyaluminum sodium carbonate [USAN] 12011-77-7
Almadrate sulfate [USAN:INN] 12125-11-0
Hydrotalcite [BAN:INN:JAN] 12304-65-3
Silodrate [USAN] 12408-47-8
Aluminum carbonate gel 12538-82-8
Dihydroxyaluminum aminoacetate anhydrous [USAN] 13682-92-3
Aloglutamol 13755-41-4
Dimephosphon 14394-26-4
Bismuth subsalicylate [USAN:JAN] 14882-18-9
Magnesium trisilicate anhydrous 14987-04-3
Magnesium hydroxycarbonate 16509-24-3
Aluminum hydroxide, dried [JAN] 21645-51-2
Magnesium Carbonate [USAN:JAN] 23389-33-5
Potassium glucaldrate [USAN:INN] 23835-15-6
Combinationture (Aluminum hydroxide, magnesium hydroxide) 37317-08-1
Combination(Aluminum hydroxide, magnesium hydroxide, simethicone) 39322-42-4
Magnesium trisilicate [USAN] 39365-87-2
Dihydroxyaluminum aminoacetate [USAN] 41354-48-7
Combination(Al mono-L-histidinate and magnesium hydroxide) 50957-57-8
Combination(Calcium carbonate, aluminum hydroxide, magnesium hydroxide) 51810-74-3

Combination(sodium acetylsalicylate, sodium bicarbonate, sodium citrate)

 53663-74-4
Sulfated polygalactoside 54392-46-0
Combination(aluminum hydroxide, magesium hydroxide, magnesium carbonate, dimethylpolsiloxane) 55874-20-9
Combination(magnesium carbonate, aluminum hydroxide) 56560-67-9
Bismuth tripotassium dicitrate 57644-54-9
Combination(bismuth aluminate, magnesium carbonate, sodium bicarbonate, cortex frangulae, fennel) 57916-93-5
Ethyl 2-hydroxycyclopentanehexanoate 60145-67-7
Combination(magnesium carbonate, aluminum hydroxide, magnesium hydroxide) 64721-20-6
Aluminum Hydroxide Combinationture with Magnesium Carbonate 66220-44-8
Combination(aluminum phosphate gel, pectin, agar) 66799-40-4
Almagate [USAN:INN] 66827-12-1
Combination(dimethicone, aluminum hydroxide gel, magnesium oxide) 68248-27-1
Magaldrate [USAN:BAN:INN] 74978-16-8
Combination(sodium citrate, sodium bicarbonate, citric acid, tartaric acid) 76095-53-9
Combination(nopoxamine lauryl sulfate, aluminum amino acetate, galactan sulfate) 76157-56-7
Combination(aluminum hydroxide, magnesium hydroxide, sorbitol, benzocaine) 76741-92-9
Combination(aluminum hydroxide, magnesium hydroxide, benzocaine) 76741-95-2
Combination(aluminum hydroxide, magnesium hydroxide, sorbitol, methylpolysiloxane) 77321-50-7
Combination(aluminum hydroxide, magnesium hydroxide, sorbitol, methylpolysiloxane, benzocaine) 77321-51-8
Combination(temazepam, Al mono-L-histidinate and magnesium hydroxide) 78065-43-7
Pyrogastrone 78515-90-9
Combination(aluminum aminoacetate, magnesium hydroxide) 79517-79-6
Combination(calcium carbonate, magnesium carbonate) 82351-35-7

Combination(sodium bicarbonate, sodium citrate)

 89964-52-3
Combination(montmorillonite beidellite, aluminum hydroxide, magnesium hydroxide) 90954-79-3
Combination(atropine sulfate, bethoxycaine, aluminum hydroxide, magnesium trisilicate) 99232-07-2
Ulsan D 111274-97-6
Ulsan DN 111274-98-7
Combination(magnesium alginate, aluminum hydroxide, magnesium carbonate, potassium bicarbonate) 111565-85-6
Combination(magnesium trisilicate, magnesium hydroxide, sodium acid phosphate, bismuth subnitrate) 115586-23-7
3-Butyryl-4-(2-methylphenylamino)-8-methoxyquinoline 115607-61-9
Kalmagin 122965-03-1
Almagcit 151126-69-1

Antidiarrheal

CAS RN.
Codeine phosphate 52-28-8

4-Bromophenacyl bromide

99-73-0
Quercitrin 522-12-3
Diphenoxylate [INN:BAN] 915-30-0
Kaolin [USAN:JAN] 1332-58-7
Diphenoxylate hydrochloride 3810-80-8
Xylonidine 4859-06-7
Cedrelanol 5937-11-1
Quercetin 3-O-gentobioside 7431-83-6
Opium 8008-60-4
Paregoric [USAN] 8029-99-0
Collagenan 8055-81-0
Mexaform 8056-07-3
Locust bean gum 9000-40-2
Pectin [USAN] 9000-69-5
Calcium polycarbophil [USAN] 9003-97-8
Collargol 9007-35-6
Bismuth subsalicylate [USAN:JAN] 14882-18-9
Isoquercitrin 21637-25-2
7-D-Glucuronic acid-5,6-dihydroxyflavone 21967-41-9
Quercetin 3-O-alpha-L-arabinoside 22255-13-6
Difenoxin [USAN:INN:BAN] 28782-42-5
Difenoxin hydrochloride 35607-36-4
Bicozamycin [INN] 38129-37-2
Loperamide [INN:BAN] 53179-11-6
N-(Aminoiminomethyl)-N'-(2,6-dimethylphenyl)urea 55831-94-2
Nufenoxole [USAN:BAN:INN] 57726-65-5
Rolgamidine [USAN:INN:BAN] 66608-04-6
Lidamidine [INN] 66871-56-5
Maletamer [USAN:BAN:INN] 67832-40-0
Tyrosyl-methionyl-glycyl-4-nitrophenylalanyl-prolinamide S-oxide 73385-60-1
Combination(difenoxine atropine sulfate) 79568-96-0
Racecadotril [INN] 81110-73-8
Kaoprompt H 81859-23-6
Octreotide [USAN:INN:BAN] 83150-76-9
Combination(tiliquinol, tilbroquinol) 87453-65-4
Tyrosyl-methionyl-O-glycyl-para-nitro-phenylalanyl-prolinamide 98311-64-9
Zaldaride [INN] 109826-26-8
Combination(tanninalbuminate, ethacrine lactate) 132590-64-8
Crofelemer [USAN] 148465-45-6
SALES SPECIFICATION

APPEARANCE

 white to off-white crystalline powder

BISMUTH CONTENT

56 - 60.0%

TOTAL SALICYLATE

36.5 - 39.5 %

NITRATE

0.5% max

LOSS ON DRYING

1.0% max

CHLORIDE

200ppm max

COPPER

10ppm max

LEAD

10ppm max

SILVER

10ppm max

ARSENIC

10ppm max

FREE SALICYLIC ACID

0.2% max

pH

2.7 - 5.0

SOLUBLE BISMUTH

pass test

ACIDITY

 pass test
TRANSPORTATION
PACKING
 
HAZARD CLASS  
UN NO.  
OTHER INFORMATION