BUSERELIN ACETATE

Synonyms. Buserelin acetate; 5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-O- tert-butyl-D- seryl-L- leucyl- L-arginyl-N-ethyl-L-prolinamide monoacetate; Buserelin; 6-(O-(1,1-Dimethylethyl)-D-serine)-9- (N-ethyl-L- prolinamide) -10-deglycinamide- luteinizing hormone-releasing factor monoacetate; Receptal; Suprefact; Des-Gly10-[D-Ser[t-Bu]6]-LH-RH ethylamide acetate; pGlu-His-Trp-Ser-Tyr-D-Ser(t-Bu)-Leu-Arg-Pro-NHEt acetate;

BUSERELIN

 

PRODUCT IDENTIFICATION

CAS RN

68630-75-1 (acetate), 57982-77-1 (free base)

EINECS RN

  

FORMULA

C60H86N16O13

MOLE WEIGHT

 1239.42

H.S CODE

 2937.19.0000

SMILES

 N1C(CC[C@H]1C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H] (C(N[C@ @H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1[C@ H](C(=O) NCC)CCC1)CCCNC(N)=N)CC(C)C)COC(C)(C)C)= O)Cc1ccc(cc1)O)=O)CO)=O)Cc1c[nH]c2c1cccc2)=O)Cc1cnc [nH]1)=O)=O.CC(=O)O

CLASSIFICATION

 

EXTRA NOTES

 A potent synthetic agonist of GONADOTROPIN-RELEASING HORMONE with D-serine substitution at residue 6, glycine10 deletion, and other modifications.

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE.

white powder

MELTING POINT

 

BOILING POINT

 

DENSITY

 

SOLUBILITY IN WATER

 

SOLVENT SOLUBILITY  

VAPOR DENSITY

 

log P(octanol-water)

  

VAPOR PRESSURE

  

AUTOIGNITION TEMP

  
pKa

 

REFRACTIVE INDEX

 

FLASH POINT

 

 

STABILITY AND REACTIVITY
STABILITY Stable under normal conditions.

INCOMPATIBLE MATERIALS

Strong oxidizing agents

POLYMERIZATION

Has not been reported

NFPA RATINGS

Health: 0, Flammability:0, Reactivity: 0

 

EXTERNAL LINKS & GENERAL DESCRIPTION

Wikipedia Linking - Buserelin

Google Scholar Search - Buserelin

Drug Information Portal (U.S. National Library of Medicine) - Buserelin

PubChem Compound Summary - Buserelin

Drug Bank -  Buserelin

KEGG (Kyoto Encyclopedia of Genes and Genomes) - Buserelin

http://www.ebi.ac.uk/ - Buserelin

http://www.ncbi.nlm.nih.gov/ - Buserelin

http://toxnet.nlm.nih.gov/
Hazardous Substances Data Bank -  Buserelin

http://prostatecanceruk.org/
What is buserelin? Buserelin is a form of hormone therapy called an LHRH (luteinizing hormonereleasing hormone) agonist. It comes as an injection and as a nasal spray. The brand name is Suprefact®. Buserelin and other LHRH agonists work by stopping the brain from telling your body to make testosterone. Without testosterone the prostate cancer cells are not able to grow. Buserelin will not cure prostate cancer but it can keep the cancer under control for many months or years.

http://wildpro.twycrosszoo.org/
Buserelin is a peptide hormone which is chemically analogous to the releasing hormone (RH) of the luteinising hormone (LH) and follicle stimulating hormone (FSH) thus a gonadotrophine releasing hormone (GnRH) analogue. The mode of action of Receptal corresponds to the physiologic-endocrinological action of the naturally occurring gonadotrophin releasing hormone: GnRH leaves the hypothalamus via the hypophyseal portal vessels and enters the anterior lobe of the hypophysis. Here it induces the secretion of the two gonadotrophins FSH and LH into the peripheral blood stream. These then act physiologically to cause maturation of ovarian follicles, ovulation and luteinization in the ovary.

 

SALES SPECIFICATION

APPEARANCE

white powder

ASSAY

95.0~105.0% (on Anhydrous, Acetic Acid free basis)

WATER

4.0% max (Karl Fischer)

ACETATE CONTENT

7.0% max (HPLC)

AMINO ACID COMPOSITION

Arg (0.9~1.1)+Leu (0.9~1.1)+Tyr (0.9~1.1)+Glu (0.9~1.1)+Pro (0.9~1.1)+His (0.9~1.1)+Arg (0.9~1.1)+Detected Try

RELATED SUBSTANCES

Individual 1.0% max, Total 5.0% max (HPLC)

PEPTIDE CONTENT

80% min (by %N)

BACTERIAL ENDOTOXINS

55.5lu/mg max

 

TRANSPORT & REGULATORY INFORMATION

UN NO.

Not regulated

HAZARD CLASS

  
PACKING GROUP  

 

SAFETY INFORMATION

HAZARD OVERVIEW

May damage fertility or the unborn child. Toxic by ingestion

GHS

  

SIGNAL WORD

Danger

PICTOGRAMS

HAZARD STATEMENTS

H302-H360

P STATEMENTS

P201-P308 + P313

EC DIRECTIVES

 

HAZARD CODES

RISK PHRASES

 60

SAFETY PHRASES

 22-36/37/39-45

 

PACKING