BUSULFAN

Synonyms. Busulfan; 1,4-Butanediol dimethanesulfonate; Myleran;Sulphabutin; Tetramethylene bis(methanesulfonate); Tetramethylene dimethane sulfonate; Tetramethylenester kyseliny methansulfonove; Leucosulfan; Mablin; Mielevcin; Mielosan; Mielucin; Milecitan; Mileran; Misulban; Mitostan; Myeleukon; Myeloleukon; Myelosan; Myelosanum; Mylecytan; Busulfex; Citosulfan; 1,4-Bis(methanesulfonoxy)butane; 1,4-Bis(methanesulfonyloxy)butane; 1,4-Butanediol dimethanesulphonate; 1,4-Butanediol dimethylsulfonate; 1,4-Dimesyloxybutane; 1,4-Dimethane sulfonyl oxybutane; 1,4-Dimethanesulfonoxybutane; 1,4-Dimethanesulfonoxylbutane; 1,4-Dimethanesulfonyloxybutane; 1,4-Dimethanesulphonyloxybutane; 1,4-Dimethylsulfonoxybutane; 1,4-Dimethylsulfonyloxybutane; Busulfano; Busulfanum;

BUSULFAN

Click for original image

 

PRODUCT IDENTIFICATION

CAS RN

55-98-1

EINECS RN

200-250-2

FORMULA

 CH3SO2O(CH2)4OSO2CH3

MOLE WEIGHT

246.30

H.S CODE

 2904.10.5000

SMILES

 O(S(C)(=O)=O)CCCCOS(C)(=O)=O

CLASSIFICATION

Alkylating agent, Antineoplastic, Immunosuppressive agent, Myeloablative agonist, Insect sterilant, Alkyl Sulfonate

EXTRA NOTES

 An alkylating agent having a selective immunosuppressive effect on BONE MARROW. It has been used in the palliative treatment of chronic myeloid leukemia (MYELOID LEUKEMIA, CHRONIC), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen. (MeSH)
Overall Carcinogenic Evaluation: Group 1

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE.

white crystalline powder

MELTING POINT

114 ~ 118 C

BOILING POINT

 

DENSITY

 

SOLUBILITY IN WATER

6.90E+04 mg/l (Practically insoluble in water, but will dissolve slowly as a hydrolysis)

SOLVENT SOLUBILITY Soluble in acetone

VAPOR DENSITY

 

log P(octanol-water)

  

VAPOR PRESSURE

 6.65E-06 mm Hg

AUTOIGNITION TEMP

  
pH

 

REFRACTIVE INDEX

 

FLASH POINT

 

 
STABILITY AND REACTIVITY
STABILITY Stable under normal conditions.

INCOMPATIBLE MATERIALS

Strong oxidizing agents.

POLYMERIZATION

Has not been reported

NFPA RATINGS

Health: 4, Flammability: 0, Reactivity: 0

 

EXTERNAL LINKS & GENERAL DESCRIPTION

Wikipedia Linking - Busulfan

Google Scholar Search - Busulfan

Drug Information Portal (U.S. National Library of Medicine) - Busulfan

PubChem Compound Summary - Busulfan

Drug Bank -  Busulfan

KEGG (Kyoto Encyclopedia of Genes and Genomes) - Busulfan

http://www.ebi.ac.uk/ - Busulfan

http://www.ncbi.nlm.nih.gov/ - Busulfan

http://toxnet.nlm.nih.gov/
Hazardous Substances Data Bank - Busulfan

http://monographs.iarc.fr/
Busulfan is an antineoplastic agent with a cell-cycle nonspecific alkylating action (unlike that of the nitrogen mustards) that has a selective depressant action on the bone marrow. In small doses, it depresses granulocytopoiesis and to a lesser extent thrombocytopoiesis, but has little effect on lymphocytes. With larger doses, severe bone-marrow depression eventually ensues.

 

SALES SPECIFICATION

APPEARANCE

white crystalline powder

IDENTIFICATION

positive (Test A,B)

CONTENT

98.0% ~ 101.0%
LOSS ON DRYING

2.0% max

HEAVY METALS

20ppm max

MELTING POINT

115 C ~ 118 C

 

TRANSPORT & REGULATORY INFORMATION

UN NO.

2811

HAZARD CLASS

 6.1
PACKING GROUP III

 

SAFETY INFORMATION

HAZARD OVERVIEW

Toxic if swalloed. Fatal in contact with skin. Fatal if inhaled. May cause cancer. OSHA Hazards:Carcinogen, Highly toxic by inhalation, Toxic by ingestion, Highly toxic by skin absorption. Target Organs:Bone marrow, EyesBone marrow, Eyes

GHS

  

SIGNAL WORD

Danger

PICTOGRAMS

HAZARD STATEMENTS

H301-H310-H330-H350

P STATEMENTS

P201-P260-P280-P284-P301 + P310-P302 + P350

EC DIRECTIVES

 

HAZARD CODES

T+

RISK PHRASES

45-26/27/28

SAFETY PHRASES

 53-36/37/39-45

 

PACKING

Preserve in light-resistant and well-closed containers