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CHLORAMBUCIL |
| Synonyms. Chlorambucil; gamma-(p-Bis(2-chloroethyl)aminophenyl)butyric acid; p-(N,N-Di-2-chlorethylaminophenyl)butyric acid; gamma-(p-Di(2-chloroethyl)aminophenyl)butyric acid; gamma-(p-bis(2-chloroethyl)aminophenyl)butyricacid; p-(N,N-Di-2-chloroethyl)aminophenyl butyric acid; p-N,N-Di-(beta-chloroethyl)aminophenyl butyric acid; Phenylbutyric acid nitrogen mustard; para-(Di(2-chloroethyl)aminophenyl)butyric acid; Phenylbuttersaeure-lost; Kyselina 4-(N,N-bis-(2-chlorethyl)-p-aminofenyl)maselna; para-N,N-Di(beta-chloroethyl)aminophenyl butyric acid; Leukeran; Linfolizin; Linfolysin; Lympholysin; N,N-Di-2-chloroethyl-gamma-p-aminophenylbutyric acid; N,N-Di-2-chloroethyl-gamma-para-aminophenyl butyric acid; Clorambucile; Clorambucilo; Chlorambucilum; Chloraminophen; Chloraminophene; Chlorbutin; Chlorbutine; Ambochlorin; 4-(Bis(2-chloroethyl)amino)benzenebutanoic acid; 4-(Bis(2-chloroethyl)amino)phenylbutyric acid; 4-(p-(Bis(2-chloroethyl)amino)phenyl)butyric acid; Ambochlorin; |
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| PRODUCT IDENTIFICATION | |
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CAS RN |
305-03-3 |
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EINECS RN |
206-162-0 |
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FORMULA |
C14H19Cl2NO2 |
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MOLE WEIGHT |
304.21 |
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H.S CODE |
2922.49.3700 |
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SMILES |
c1(N(CCCl)CCCl)ccc(cc1)CCCC(O)=O |
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CLASSIFICATION |
Alkylating agent, Antineoplastic agent |
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EXTRA NOTES |
A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
(MeSH) Overall Carcinogenic Evaluation: Group 1 |
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| PHYSICAL AND CHEMICAL PROPERTIES | |
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PHYSICAL STATE. |
white to off-white crystalline powder |
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MELTING POINT |
65 C ~ 69 C |
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BOILING POINT |
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DENSITY |
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SOLUBILITY IN WATER |
Practically insoluble |
| SOLVENT SOLUBILITY | Soluble in ether, in 1.5 parts alcohol, in 2.5 parts chloroform, in 2 parts acetone. Dissolves in dilute sodium hydroxide |
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VAPOR DENSITY |
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log P(octanol-water) |
1.7 |
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AUTOIGNITION TEMP |
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| pK |
15.29 |
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REFRACTIVE INDEX |
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FLASH POINT |
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| STABILITY AND REACTIVITY | |
| STABILITY | Stable under normal conditions. |
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INCOMPATIBLE MATERIALS |
Strong oxidizing agents. |
| POLYMERIZATION |
Has not been reported |
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NFPA RATINGS |
Health: 2, Flammability: 0, Reactivity: 0 |
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| EXTERNAL LINKS & GENERAL DESCRIPTION |
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Wikipedia Linking - Chlorambucil Google Scholar Search - Chlorambucil Drug Information Portal (U.S. National Library of Medicine) - Chlorambucil PubChem Compound Summary - Chlorambucil Drug Bank - Chlorambucil KEGG (Kyoto Encyclopedia of Genes and Genomes) - Chlorambucil http://www.ebi.ac.uk/ - Chlorambucil http://www.ncbi.nlm.nih.gov/ - Chlorambucil http://toxnet.nlm.nih.gov/ http://www.mims.com/ |
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| SALES SPECIFICATION | |
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APPEARANCE |
white to off-white crystalline powder |
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IDENTIFICATION |
positive (test A, B) |
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ASSAY |
98.0% ~ 101.0% |
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MELTING POINT |
65 ~ 69 C |
| WATER |
0.5% max |
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| TRANSPORT & REGULATORY INFORMATION | |
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UN NO. |
2811 |
| HAZARD CLASS |
6.1 |
| PACKING GROUP | III |
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| SAFETY INFORMATION |
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HAZARD OVERVIEW |
Toxic if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. May cause cancer. OSHA Hazards: Carcinogen, Target Organ Effect, Toxic by ingestion, Irritant. Target Organs:Bone marrow |
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GHS |
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SIGNAL WORD |
Danger |
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PICTOGRAMS |
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HAZARD STATEMENTS |
H301-H315-H319-H335-H350 |
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P STATEMENTS |
P201-P261-P301 + P310-P305 + P351 + P338-P308 + P313 |
| EC DIRECTIVES |
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| HAZARD CODES |
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RISK PHRASES |
45-25-36/37/38 |
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SAFETY PHRASES |
53-26-45 |
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| PACKING |
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