CIPROFIBRATE

Synonyms. Ciprofibrate; 2-(4-(2,2-Dichlorocyclopropyl)phenoxy)2-methylpropanoic acid; Ciprofibrato; Ciprofibratum; 2-(p-(2,2-Dichlorocyclopropyl)phenoxy)-2-methylpropionic acid; 2-(4-(2,2-Dichlorocyclopropyl)phenoxy)-2-methylpropionic acid;

CIPROFIBRATE

Click for original image

 

PRODUCT IDENTIFICATION

CAS RN

52214-84-3

EINECS RN

257-744-6

FORMULA

 C13H14Cl2O3

MOLE WEIGHT

289.15

H.S CODE

 2918.99.3000

SMILES

 c1([C@@H]2C(Cl)(Cl)C2)ccc(OC(C(O)=O)(C)C)cc1

CLASSIFICATION

Antihyperlipoproteinemic, Antilipemic agent, Antimetabolite, Hypolipidemic Agent, Lipid Regulating Agent, Peroxisome Proliferator

EXTRA NOTES

Peroxisome proliferator-activated receptor α (PPARα) agonist

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE.

white to off-white power

MELTING POINT

115 ~ 120 C

BOILING POINT

 

DENSITY

 

SOLUBILITY IN WATER

 

SOLVENT SOLUBILITY

 

VAPOR DENSITY

 

log P(octanol-water)

 3.94

VAPOR PRESSURE

  

AUTOIGNITION TEMP

  
pH

 

REFRACTIVE INDEX

 

FLASH POINT

 

 

STABILITY AND REACTIVITY
STABILITY Stable under normal conditions.

INCOMPATIBLE MATERIALS

Strong oxidizing agents

POLYMERIZATION

Has not been reported

NFPA RATINGS

Health: 1, Flammability:0, Reactivity: 0

 

EXTERNAL LINKS & GENERAL DESCRIPTION

Wikipedia Linking - Ciprofibrate

Google Scholar Search - Ciprofibrate

Drug Information Portal (U.S. National Library of Medicine) - Ciprofibrate

PubChem Compound Summary - Ciprofibrate

KEGG (Kyoto Encyclopedia of Genes and Genomes) - Ciprofibrate

Chemical Entities of Biological Interest (ChEBI) - Ciprofibrate

http://www.ncbi.nlm.nih.gov/ - Ciprofibrate

http://www.sigmaaldrich.com/
Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined.

 

SALES SPECIFICATION

APPEARANCE

white to off-white power

PURUTY

98.0% min (HPLC)

LOSS ON DRYING

5.0% max

HEAVY METALS

20ppm max

MELTING POINT

115 ~ 120 C

 

TRANSPORT & REGULATORY INFORMATION

UN NO.

Not regulated

HAZARD CLASS

  
PACKING GROUP  

 

SAFETY INFORMATION

HAZARD OVERVIEW

OSHA Hazards: Target Organ Effect, Target Organs: Liver, Skeletal muscle, Blood, Gastrointestinal tract. GHS Classification: Carcinogenicity Category 1B. Eyes: May cause eye irritation. Skin: May be harmful if absorbed through skin. May cause skin irritation. Inhalation: May be harmful if inhaled. May cause respiratory tract irritation. Ingestion: May be harmful if swallowed.

GHS

  

SIGNAL WORD

Danger

PICTOGRAMS

HAZARD STATEMENTS

H350

P STATEMENTS

P201-P308 + P313

EC DIRECTIVES

 

HAZARD CODES

RISK PHRASES

45

SAFETY PHRASES

 53-22-36/37/39-45

 

PACKING

Preserve in light-resistant and well-closed containers

 

PRICE INFORMATION