COLCHICINE

PRODUCT IDENTIFICATION
CAS NO. 64-86-8

 

EINECS NO. 200-598-5
FORMULA C22H25NO6
MOL WT. 399.44

H.S. CODE

 2939.99.0000

TOXICITY

Oral, mouse: LD50 = 5886 ug/kg
SYNONYMS

7-alpha-H-Colchicine; 7alphaH-Colchicine; Colchisol; Colchysat;

(S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)acetamide; 1,2,3,10-Tetramethoxy-7-acetamido-6,7-dihydrobenzo(a)heptalen-9(5H)-one; Colchicin; Colchicina; Colchicine; Colchicinum; Colchineos; Colcin; Colcrys; Colsaloid; Condylon; Goutnil; Kolkicin; N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)acetamide; N-Acetyl trimethylcolchicinic acid methylether; Other RN: 5843-86-7, 30512-31-3

SMILES

 c12c3c([C@H](CCc2cc(c(c1OC)OC)OC)NC(=O)C)cc(=O)c(cc3)OC

CLASSIFICATION

Antimitotic, Antirheumatic, Gout suppressant, Mitosis Modulator, Tubulin Modulator
EXTRA NOTES A major alkaloid from Colchicum autumnale L. and found also in other Colchicum species. Its primary therapeutic use is in the treatment of gout, but it has been used also in the therapy of familial Mediterranean fever (periodic disease).

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE yellow powder
MELTING POINT 150 - 160 C (Decomposes)
BOILING POINT

 

RELATIVE DENSITY  
SOLUBILITY IN WATER

45 g/l at 20 C

SOLVENT SOLUBILITY

 Soluble in alcohol and chloroform
pH  
VAPOR DENSITY

 

REFRACTIVE INDEX

 

NFPA RATINGS

Health: 3, Flammability: 1, Reactivity: 0

AUTOIGNITION

 

FLASH POINT

 

STABILITY Stable under normal conditions.

EXTERNAL LINKS & GENERAL DESCRIPTION

Wikipedia Linking

Google Scholar Search

Drug Information Portal (U.S. National Library of Medicine) - Colchicine

PubChem Compound Summary - Colchicine

IPCS INCHEM -  Colchicine

Drug Bank -  Colchicine

KEGG (Kyoto Encyclopedia of Genes and Genomes) -  Colchicine

http://www.ebi.ac.uk/chebi/ -  Colchicine

http://www.ncbi.nlm.nih.gov/ -  Colchicine

The Emergency Response Safety and Health Database - Colchicine

Local:
Colchicine is a tricyclic alkaloid prepared from Colchicum autumnale L. and found also in other Colchicum species. Colchicine inhibits microtubule polymerization by binding to tubulin. It is a drug used to prevent painful attacks of joint inflammation due to deposits of uric acid in the joint (gouty arthritis).and febrile attacks in familial Mediterranean fever. The mechanism is not clear, but it is considered that colchicine helps to reduce lactic acid production by leukocytes and reduce phagocytosis, with abatement of the inflammatory response. Colchicine has other pharmacologic effect in secondary amyloidosis (AA), and scleroderma. Colchicine is a pale yellow powder soluble in water. The chemical designation is N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[d]heptalen-7-yl]acetamide.COLCHICINE

Antigout drugs include:

Product

CAS RN.

Probenecid

57-66-9

Sulfinpyrazone

57-96-5
Indomethacin 53-86-1
Colchicine 64-86-8
Allopurinol 315-30-0
Naproxen 22204-53-1
Pranoprofen 52549-17-4
Amflutizole 82114-19-0
Febuxostat 144060-53-7
SALES SPECIFICATION

APPEARANCE

 yellow powder

CONTENT

97.0 - 101.0%

LOSS ON DRYING

1.0% max
SPECIFIC ROTATION -240° ~ -250°
TRANSPORTATION
PACKING
 
HAZARD CLASS 6.1 (Packing Group: I)
UN NO.

1544

SAFETY INFORMATION

HAZARD OVERVIEW

 Colchicine is a highly toxic plant hormone that is used medically in the treatment of gout and in scientific research. Colchicine stops the process of cell division (it is an antimitotic agent). Exposure to colchicine can be fatal in very small doses (e.g., 7 to 65 mg). Colchicine is derived from the meadow saffron or autumn crocus plant (Colchicum autumnale), which is locally abundant in meadows throughout most of Europe and has become naturalized in parts of North America. It can also be found in the tubers of the Glory Lily (Gloriosa superba) found primarily in Florida. It is odorless or nearly so and has a very bitter taste. It is produced in tablets, granules, and ampules of sterile solution. It has uses in the production of legitimate and illicit plant production.

GHS

 
SIGNAL WORD Danger

PICTOGRAMS

HAZARD STATEMENTS

H300  Fatal if swallowed
H340  May cause genetic defects

PRECAUTIONARY STATEMENTS

P201  Obtain special instructions before use
P301 + P310  IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician
P308 + P313  IF exposed or concerned: Get medical advice/attention
EC DIRECTIVES

 
HAZARD CODES

T+ Very Toxic

RISK PHRASES

28  Very toxic if swallowed.
46  May cause heritable genetic damage.

SAFETY PHRASES

13 Keep away from food, drink and animal feeding stuffs
45  In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)

PRICE INFORMATION