PRODUCT IDENTIFICATION
TOXICITY
H.S. CODE
(R)-4-Amino-3-isoxazolidinone; D-4-Amino-3-isoxazolidinone; Cicloserina; Cicloserina; Closina; Cyclo-D-serine; Cyclorin; Cycloserine; Cycloserinum; D-4-Amino-3-isossazolidone; D-4-Amino-3-isoxazolidinone; D-4-Amino-3-isoxazolidone; DCS; Farmiserina; Miroserina; Miroseryn; Novoserin; Orientomycin; Oxamicina; Oxamycin; Seromycin; Tebemicina; Tisomycin;
CLASSIFICATION
EXTRA NOTES
Mode of Action: Inhibits cell wall biosynthesis (D-Ala peptide
bond formation). Also prevents conversion of D-Ala to L-Ala. Bacteriostatic.
Mode
of Resistance: D-Ala transport interference
PHYSICAL AND CHEMICAL PROPERTIES
white to slightly yellow crystalline powder
155 C
REFRACTIVE INDEX
NFPA RATINGS
Health hazard: 1, Fire: 0, Reactivity Hazard: 0
AUTOIGNITION
FLASH POINT
EXTERNAL LINKS & GENERAL DESCRIPTION
Drug Information Portal (U.S. National Library of Medicine) - Cycloserine
PubChem Compound Summary - D-cycloserine
http://www.netdoctor.co.uk/
There are two stages in the treatment for tuberculosis. In the first two
months treatment is aimed at killing as many bacteria as possible. Therefore
several anti-TB drugs with different mechanisms of action are used at the same
time (usually rifampicin, pyrazinamide, isoniazid and ethambutol). After this
time some of the medicines are stopped and the others (usually rifampicin and
isoniazid) are continued for a further four months to kill any remaining
bacteria. Cycloserine is only used in second stage of treatment and when the
bacteria are resisant to the other medicines.
KEGG (Kyoto Encyclopedia of Genes and Genomes) - Cycloserine
Local:
Cycloserine
shows a good activity on tuberculosis and especially drug resistant tubercle
bacilli.
APPEARANCE
white to slightly yellow crystalline powder
IDENTIFICATION
passes Test A, B
ASSAY
SPECIFIC ROTATION
+108° ~ +114°
pH
5.5 ~ 6.5 C
LOSS ON DRYING
1.0% max
GHS
Not a dangerous substance according to GHS.