EPINASTINE HYDROCHLORIDE

PRODUCT IDENTIFICATION
CAS NO. 80012-43-7 (parent), 108929-04-0 (hydrochloride)

EPINASTINE

EINECS NO.  
FORMULA C16H15N3.HCl
MOL WT. 285.77

H.S. CODE

  

TOXICITY

  
SYNONYMS Epinastina; Epinastinum; (+-)-Epinastine hydrochloride;
Epinastine monohydrochloride; 3-Amino-9,13b-dihydro-1H-dibenz(c,f)imidazo(1,5-a)azepine hydrochloride; 1H-Dibenz(c,f)imidazo(1,5-a)azepin-3-amino, 9,13b-dihydro- hydrochloride; Other CAS RN.: 134507-59-8; 80012-44-8;
DERIVATION

 

CLASSIFICATION

  

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white to yellow crystalline powder
MELTING POINT 270 C
BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER  
pH  
VAPOR DENSITY

 

REFRACTIVE INDEX

  

NFPA RATINGS

  

AUTOIGNITION

 

FLASH POINT

 

STABILITY Stable under normal conditions.

GENERAL DESCRIPTION & APPLICATIONS
Epinastine is a histamine H1 antagonist that blocks the actions of endogenous histamine by selectively binding to but not activating histamine H1 receptors. Such agents also include the classical antihistamines that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. These agents also have sedative, anticholinergic, and antiemetic effects. They are used for the relief of allergic symptoms and as antiemetics, antivertigo agents, sedatives, and antidyskinetics in parkinsonism. Epinastine is used in eye drops to treat allergic conjunctivitis.

SALES SPECIFICATION
EPINASTINE.HCl

APPEARANCE

 white to yellow crystalline powder
IDENTIFICATION Complies

ASSAY

98.5 - 101.0% (dry basis)

pH

3.0 - 5.5

ASH

0.5% max
TRANSPORTATION
PACKING
 
HAZARD CLASS  
UN NO.  
OTHER INFORMATION