FLUCONAZOLE

PRODUCT IDENTIFICATION
CAS NO. 86386-73-4, 123631-92-5

FLUCONAZOLE

EINECS NO.  
FORMULA C13H12F2N6O
MOL WT. 306.27

TOXICITY

Oral Rat LD50: 1271mg/kg

H.S. CODE

 2933.99.7500
SYNONYMS Fluconazole; Flunizol; Flusol; Fluzon; Forcan; Fungata;
2,4-Difluoro-alpha,alpha-bis(1H-1,2,4-triazol-1-ylmethyl)benzyl alcohol; Afungil; Alflucoz; Baten; 2-(2,4-Difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-yl)-2-propanol; Diflucan; Dimycon; Fluconazol; Fluconazolum; Fluconazolum; Flucostat; Flukezol; Flunazol;  Oxifugol; Pritenzol; Triconal; Triflucan; Zoltec; Zonal; alpha-(2,4-Difluorophenyl)-alpha-(1H-1,2,4-triazol-1-ylmethyl)- 1H-1,2,4-triazole -1-ethanol;
SMILES c1c(cc(c(C(Cn2ncnc2)(O)Cn2cncn2)c1)F)F

CLASSIFICATION

Antibiotic, Anti-Infective, Antifungal, Triazole

EXTRA NOTES

 Triazole antifungal agent that is used to treat oropharyngeal candidiasis and cryptococcal meningitis in AIDS.

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white to off-white crystalline powder
MELTING POINT 138- 142 C
BOILING POINT

 

SPECIFIC GRAVITY  
SOLUBILITY IN WATER  
pH  
VAPOR DENSITY

 

REFRACTIVE INDEX

  

NFPA RATINGS

  

AUTOIGNITION

 

FLASH POINT

 

STABILITY Stable under normal conditions.

EXTERNAL LINKS & GENERAL DESCRIPTION

Wikipedia Linking

Google Scholar Search

Drug Information Portal (U.S. National Library of Medicine) - Fluconazole

http://www.fungalresearchtrust.org/
Fluconazole is active against most Candida species, with the absolute exception of Candida krusei and partial exception of Candida glabrata and a small number of isolates of Candida albicans, Candida tropicalis, Candida parapsilosis and other rare species. It is also active against the vast majority of Cryptococcus neoformans isolates. It is active against many other yeasts including Trichosporon beigelii, Rhodotorula rubra, and the dimorphic endemic fungi including Blastomyces dermatitidis, Coccidioides immitis, Histoplasma capsulatum and Paracoccidioides brasiliensis. It is less active than itraconazole against these dimorphic fungi. It is not active against Aspergillus or Mucorales. It is active against skin fungi such as Trichophyton.
Increasing resistance in Candida albicans in patients with AIDS has been reported. Typical rates of resistance, in Candida albicans in a general hospital are 3-6%, in Candida albicans in AIDS 10-15%, in Candida krusei 100%, in Candida glabrata ~50-70%, in Candida tropicalis 10-30% and in other Candida species less than 5%

http://www.eucast.org/
Fluconazole is an azole antifungal agent active against Candida spp. and Cryptococcus spp. It can be administered orally or intravenously. It has been used for treating Candida infections, and is effective in treating infections caused by strains of Candida albicans, Candida tropicalis and Candida parapsilosis without acquired resistance mechanisms. The drug is ineffective for treating infections caused by Candida krusei, which is naturally resistant. The response of infections caused by Candida glabrata is variable, as the wild-type MIC distribution straddles most reasonable MIC breakpoints. Every attempt should be made to identify Candida isolates to the species level before or in conjunction with antimicrobial susceptibility testing. The EUCAST-AFST (European Committee on Antimicrobial Susceptibility Testing-Subcommittee on Antifungal Susceptibility Testing) has determined breakpoints of fluconazole for Candida spp.
SALES SPECIFICATION

APPEARANCE

 white to off-white crystalline powder

ASSAY

98.0% ~ 102.0%
MELTING POINT 138- 142 C

Fe

0.002% max

RELATED SUBSTANCES

0.5% max
LOSS ON DRYING

0.5% max

RESIDUE ON IGNITION

0.1% max

CLARITY OF SOLUTION

 Transparent
TRANSPORTATION
PACKING
 
HAZARD CLASS  
UN NO.  
SAFETY INFORMATION
Hazard Symbols: XN, Risk Phrases: 22-36/37/38, Safety Phrases: 26-36
PRICE INFORMATION