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FOTEMUSTINE |
| Synonyms. Fotemustine; P-(1-((((2-Chloroethyl)nitrosoamino)carbonyl)amino)ethyl)-phosphonic acid diethyl ester; Mustophorane; Diethyl (1-(3-(2-chloroethyl)-3-nitrosoureido)ethyl)phosphonate; Muphoran; Mustoforan; Fotemustina; Fotemustinum; |
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| PRODUCT IDENTIFICATION | |
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CAS RN |
92118-27-9 |
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EINECS RN |
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FORMULA |
C9H19ClN3O5P |
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MOLE WEIGHT |
315.69 |
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H.S CODE |
2931.90.9043 |
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SMILES |
P(=O)(OCC)(OCC)C(NC(=O)N(CCCl)N=O)C |
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CLASSIFICATION |
Antineoplastic agent, Alkylating agent, Nitrosourea |
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EXTRA NOTES |
Fotemustine is a third generation nitrosourea, chloroethylating agent used in the treatment of glioma and malignant melanoma.(sigmaaldrich) Amino acid-linked nitrosourea alkylating agent |
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| PHYSICAL AND CHEMICAL PROPERTIES | |
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PHYSICAL STATE. |
white to yellow crystalline powder |
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MELTING POINT |
84 ~ 86 C |
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BOILING POINT |
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DENSITY |
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SOLUBILITY IN WATER |
≥1 mg/ml |
| SOLVENT SOLUBILITY | |
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VAPOR DENSITY |
10.9 |
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log P(octanol-water) |
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VAPOR PRESSURE |
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AUTOIGNITION TEMP |
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| pH |
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REFRACTIVE INDEX |
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FLASH POINT |
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| STABILITY AND REACTIVITY | |
| STABILITY | Stable under normal conditions. |
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INCOMPATIBLE MATERIALS |
Strong oxidizing agents |
| POLYMERIZATION |
Has not been reported |
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NFPA RATINGS |
Health: 0, Flammability: 0, Reactivity: 0 |
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| EXTERNAL LINKS & GENERAL DESCRIPTION |
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Wikipedia Linking - Fotemustine Google Scholar Search - Fotemustine Drug Information Portal (U.S. National Library of Medicine) - Fotemustine PubChem Compound Summary - Fotemustine Drug Bank - Fotemustine KEGG (Kyoto Encyclopedia of Genes and Genomes) - Fotemustine http://www.ebi.ac.uk/ - Fotemustine http://www.ncbi.nlm.nih.gov/ - Fotemustine http://toxnet.nlm.nih.gov/ |
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| SALES SPECIFICATION | |
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APPEARANCE |
white to yellow crystalline powder |
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IDENTIFICATION |
positive (Test A,B) |
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CONTENT |
98.5% ~ 101.5% |
| LOSS ON DRYING |
1.0% max |
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HEAVY METALS |
20ppm max |
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RELATED SUBSTANCES |
Total impurities:1.0% max, single impurity:0.5% max |
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MELTING POINT |
84 ~ 86 C |
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| TRANSPORT & REGULATORY INFORMATION | |
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UN NO. |
Not regulated |
| HAZARD CLASS |
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| PACKING GROUP | |
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| SAFETY INFORMATION |
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HAZARD OVERVIEW |
May be harmful if inhaled. May cause respiratory tract irritation. May be harmful if swallowed. May be harmful if absorbed through skin. May cause skin irritation. May cause eye irritation.Suspected of causing cancer. OSHA Hazards:Carcinogen. Target Organs:Eyes, Skin |
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GHS |
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SIGNAL WORD |
Warning |
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PICTOGRAMS |
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HAZARD STATEMENTS |
H351 |
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P STATEMENTS |
P281 |
| EC DIRECTIVES |
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| HAZARD CODES |
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RISK PHRASES |
40 |
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SAFETY PHRASES |
36/37 |
Xn|
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| PACKING |
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Preserve in light-resistant and well-closed containers |