FRAMYCETIN SULPHATE

PRODUCT IDENTIFICATION
CAS NO. 4146-30-9 (sulphate), 119-04-0 (parent)

FRAMYCETIN SULPHATE

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EINECS NO. 223-969-3
FORMULA C23H48N6O17S
MOL WT. 712.28

H.S. CODE

 2941.90.1010

TOXICITY

  
SYNONYMS Soframycin sulfate; Neomycin B sulfate;
(2R,3S,4R,5R,6R)-5-Amino-2-(aminomethyl)-6-((1R,2R,3S,4R,6S)-4,6-diamino-2- ((2S,3R,4S,5R) -4-((2S,3S, 4S, 5R,6R)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl) oxy-3-hydroxy-5-(hydroxymethyl)oxolan- 2-yl)oxy-3-hydroxycyclohexyl)oxyoxane-3,4- diol; sulfuric acid; O-2,6-diamino-2,6-dideoxy-alpha-D- glucopyranosyl -(1-4)-O-(O-2,6-diamino-2,6- dideoxy-beta-L- idopyranosyl-(1-3)-beta-D-ribofuranosyl -(1-5))-2-deoxy-D-streptamine sulfate; Enterfram; Framicetina; Framycetin; Framycetine; Framycetinum;
SMILES

NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N) [C@@H](O)[C@H]2O [C@@H]2O[C@H](CO)[C@H](O[C@@ H]3O[C@H](CN)[C@H](O)[C@H](O) [C@@H]3N)[C@H]2 O)[C@H](N)[C@H](O)[C@@H]1O.OS(O)(=O)=O

CLASSIFICATION

Antibacterial, Anti-Infective

EXTRA NOTES

 A component of NEOMYCIN that is produced by Streptomyces fradiae. On hydrolysis it yields neamine and neobiosamine B. (From Merck Index, 11th ed)

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white to yellowish powder
MELTING POINT  
BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER soluble
pH  
VAPOR DENSITY

 

AUTOIGNITION

 

NFPA RATINGS

 

REFRACTIVE INDEX

  
FLASH POINT

 

STABILITY

Stable under ordinary conditions

EXTERNAL LINKS & GENERAL DESCRIPTION

Wikipedia Linking - Framycetin

Google Scholar Search - Framycetin sulfate

Drug Information Portal (U.S. National Library of Medicine) - Framycetin sulfate

PubChem Compound Summary - Framycetin sulfate

Drug Bank -  Framycetin

KEGG (Kyoto Encyclopedia of Genes and Genomes) - Framycetin sulfate

http://www.ebi.ac.uk/ - Framycetin

http://www.ncbi.nlm.nih.gov/ - Framycetin sulfate

Local:
Aminoglycoside is any of a group of antibiotics derived from various species of Streptomyces or Micromonosporaceae, while some of which are produced synthetically. Aminoglycosides inhibit bacterial protein synthesis by binding with the 30S ribosomal subunit. They include;

 

Aminoglycoside antibiotic

CAS RN.

Adechlorin 96328-17-5
Gentamicin 1403-66-3

Netilmicin

 56391-56-1
Gentamicin sulfate 1405-41-0
Amikacin 37517-28-5
Apramycin 37321-09-8
Butirosin sulfate anhydrous 51022-98-1
Chlorothricin 34707-92-1
Dibekacin 34493-98-6
Dihydrostreptomycin Sulfate 5490-27-7
Framycetin 119-04-0
Geneticin 49863-47-0
Hygromycin A 6379-56-2
Hygromycin B 31282-04-9
Isepamicin 58152-03-7
Kanamycin 59-01-8
Nebramycin 11048-13-8
Neomycin 1404-04-2
O-Demethylchlorothricin 134637-04-0
O-Demethylhydroxychlorothricin 134615-17-1
Paromomycin 7542-37-2

Puromycin

53-79-2

Ribostamycin 25546-65-0
Sisomicin 32385-11-8
Streptomycin 57-92-1
Streptozocin 18883-66-4
Tobramycin sulfate 49842-07-1
Tobramycin 32986-56-4

 
Neomycin is an aminoglycoside antibiotic derived from the metabolic Streptomyces fradiae, effective against a wide range of aerobic gram-negative bacilli and some gram-positive bacteria. It consists of three components A, B, and C. The main form is B, The chemical designation is 2-Deoxy-4-O-(2,6-diamino-2,6-dideoxy-alpha-D-glucopyranosyl)-5-O-(3-O- (2,6-diamino-2,6-dideoxy- beta-L-idopyranosyl)-bete-D-ribofuranosyl)-D-streptamine. Neomycin is applied topically to the skin, conjunctiva, and ears in the treatment of infections due to susceptible organisms. It is used in combination with other antibiotics or antiinflammatory steroids. Neomycin sulfate is administered orally in preoperative bowel preparation. Neomycin sulfate is a white to yellowish powder; hygroscopic; very soluble in water; slightly soluble in alcohol; insoluble in acetone.

Neomycin and Framycetin are not absorbed from the gastrointestinal tract and are thus found in many topical medications such as creams, ointments and eyedrops. They can also be used for gastrointestinal infections. Framycetin yields neamine and neobiosamine B on hydrolysis.

SALES SPECIFICATION

APPEARANCE

 white to yellowish powder

POTENCY

630 μm/mg min(Anhydrous basis)

ASSAY

90.0~100.0%(HPLC)

IDENTIFICATION

positive (Test A, Test B,)

SULFATE

 27.0 - 31.0%

pH

 6.0 - 7.0

RELATED SUBSTANCES

 Neomycin C: 3.0% max
Neamine: 1.0% max
Total Impurity: 3.0% max

LOSS ON DRYING

8.0% max

OPTICAL ROTATION

+52.5º  ~ +55.0º

SULFATED ASH

1.0% max

PARTICLE SIZE

< 25 μm (90.0% min)

TRANSPORTATION
PACKING
 
HAZARD CLASS  
UN NO.  
SAFETY INFORMATION