PRODUCT IDENTIFICATION
20098-14-0
H.S. CODE
TOXICITY
CLASSIFICATION
Adamantanone
EXTRA NOTES
PHYSICAL AND CHEMICAL PROPERTIES
> 300 C
AUTOIGNITION
NFPA RATINGS
REFRACTIVE INDEX
Stable under ordinary conditions.
EXTERNAL LINKS & GENERAL DESCRIPTION
PubChem Compound Summary - 5-Hydroxy-2-adamantanone
KEGG (Kyoto Encyclopedia of Genes and Genomes) - 5-Hydroxy-2-adamantanone
http://www.ebi.ac.uk/chebi/ - 5-Hydroxy-2-adamantanone
Drug Bank - Idramantone
http://www.sciencedirect.com/
Adamantyl-based compounds are used clinically for the
treatment of neurological conditions, as anti-viral agents and as agents against
type 2 diabetes. The value of the adamantyl group in drug design is
multidimensional. The hydrophobic substituent constant for the adamantyl group
has been estimated from the calculated partition coefficients (clogP
values) of 31 adamantyl-bearing compounds in the clinic or in development as
πadamantyl = 3.1, which indicates that the logP
value of a compound with high water solubility (logP < < 0) could
be moved with an adamantyl-based modification to a region that is more
clinically useful. The steric bulk of the adamantyl group can: (i) restrict or
modulate intramolecular reactivity; and (ii) impede the access of hydrolytic
enzymes, thereby increasing drug stability and plasma half life. The value of
the adamantyl group in drug design has been recognized most recently in the
design of agents to treat iron overload disease (in development), malaria (in
clinical trials) and type 2 diabetes (in the clinic).
APPEARANCE
ASSAY
99.0% min
MELTING POINT
> 300 C
LOSS ON DRYING
1.0% max
RESIDUE ON IGNITION
0.2% max
HEAVY METALS
10ppm max
Xi
Irritant
RISK PHRASES
36/37/38: Irritating to eyes, respiratory system and skin
SAFETY PHRASES
24/25: Avoid contact with skin and eyes.