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KITASAMYCIN |
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Synonyms. Kitasamycin;
Ayermicina; Kitasamycine; Kitasamycinum;
Quitasamicina; Selectomycin; Stereomycine; Syneptine;
Turimycin; Leucomycin V; 2-[(4R,5S,6S,7R,9R,10R,11E,13E,16R)-6-[(2S,3R,4R,5S,6R)-5-[(2S,4R,5S,6S)-4,5-
dihydroxy-4,6-dimethyloxan-2-yl]oxy-4-(dimethylamino)-3-hydroxy-6-methyloxan-
2-yl]oxy-4,10-dihydroxy-5-methoxy-9,16-dimethyl-2-oxo-1-oxacyclohexadeca-11,
13-dien-7-yl]acetaldehyde; |
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| PRODUCT
IDENTIFICATION
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CAS
RN
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1392-21-8, 39405-35-1 |
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EINECS
RN |
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FORMULA |
C40H67NO14 |
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MOLE
WEIGHT
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785.96 |
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H.S CODE
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2941.90.1010 |
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SMILES
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O([C@@H]1[C@H](C[C@H]([C@@H](C=CC=CC[C@H](OC(C[C
@H]([C@@H]1OC)O)=O)C)O)C)CC=O)[C@@H]1[C@@H]([C@@ H]([C@@H](O[C@@H]2C[C@@]([C@@H](O*)[C@@H](O2)C)
(C)O)CO1)N(C)C)O |
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CLASSIFICATION
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Antibacterial, |
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EXTRA
NOTES
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A macrolide antibiotic produced by Streptomyces kitasatoensis. The drug has
antimicrobial activity against a wide spectrum of pathogens. |
| PHYSICAL
AND CHEMICAL PROPERTIES
|
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PHYSICAL
STATE. |
white to yellowish powder
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MELTING
POINT |
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BOILING
POINT |
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DENSITY
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SOLUBILITY
IN WATER |
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SOLVENT
SOLUBILITY |
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VAPOR
DENSITY |
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log P(octanol-water)
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VAPOR
PRESSURE |
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AUTOIGNITION TEMP
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pH |
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REFRACTIVE
INDEX
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FLASH
POINT |
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| STABILITY AND REACTIVITY |
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STABILITY |
Stable
under normal conditions. |
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INCOMPATIBLE
MATERIALS
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n/a
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POLYMERIZATION |
Has not been reported
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NFPA
RATINGS
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Health hazard: 1, Flammability: 0, Physical hazards:
0
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| EXTERNAL LINKS
& GENERAL
DESCRIPTION
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Wikipedia
Linking
Google
Scholar Search
Drug
Information Portal (U.S. National Library of Medicine) - Kitasamycin
PubChem
Compound
Summary
- Kitasamycin
Drug
Bank - Kitasamycin
KEGG
(Kyoto Encyclopedia of Genes and Genomes) - Kitasamycin
http://www.ebi.ac.uk/
- Kitasamycin
http://www.ncbi.nlm.nih.gov/
- Kitasamycin
http://www.biology-online.org/
Kitasamycin was developed by Japanese Kitasa Institute in 1960. The antibiotic
was produced by Streptomycin kitasatoensis with the active compound of 16 carbon
macrolide. The antibiotic has other names such as Selectomycin， leucomycin,
ayermicina, sineptin. This antibiotic was approved by Ministry of Agriculture in
2001 as the growth promoter additive in poultry and swine to control and prevent
digestive and respiratory diseases. Pharmacology Characteristic: Belonging to the macrolide antibiotic, its
antibacterial activity is similar to tylosin, erythromycin, spiramycin and
oleandomycin. The mode of action is to inhibit the protein synthesis process.
Its inhibition spectrum includes Mycoplasmas, Gram-positive bacteria, some
Gram-negative bacteria, Leptospira, Rickettsia. It also inhibits most bacteria
resistant to penicillin, oxytetracycline, chlortetracycline, erythromycin and
chloramphenicol bacteria strains. It is a safe and high efficacy
growth-promoting additive for swine and poultry.
http://aac.asm.org/
Biosynthesis of Kitasamycin(Leucomycin) by Leucine Analog-Resistant Mutants of
Streptomyces kitasatoensis
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| SALES
SPECIFICATION
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|
APPEARANCE |
white to yellowish powder
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|
IDENTIFICATION |
passes test
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|
ASSAY
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90.0%
- 100.0%
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|
BIOLOGICAL POTENCY |
450u/mg ~ 550u/mg |
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LOSS
ON DRYING
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10.0% max
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|
HEAVY METALS |
20ppm max
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|
ARSENIC |
5ppm max
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| TRANSPORT
& REGULATORY INFORMATION
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UN
NO. |
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| HAZARD SYMBOL
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PACKING GROUP |
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