KITASAMYCIN

Synonyms. Kitasamycin; Ayermicina; Kitasamycine; Kitasamycinum; Quitasamicina; Selectomycin; Stereomycine; Syneptine; Turimycin; Leucomycin V; 2-[(4R,5S,6S,7R,9R,10R,11E,13E,16R)-6-[(2S,3R,4R,5S,6R)-5-[(2S,4R,5S,6S)-4,5- dihydroxy-4,6-dimethyloxan-2-yl]oxy-4-(dimethylamino)-3-hydroxy-6-methyloxan- 2-yl]oxy-4,10-dihydroxy-5-methoxy-9,16-dimethyl-2-oxo-1-oxacyclohexadeca-11, 13-dien-7-yl]acetaldehyde;

KITASAMYCIN

 

PRODUCT IDENTIFICATION

CAS RN

1392-21-8, 39405-35-1

EINECS RN

 

FORMULA

C40H67NO14

MOLE WEIGHT

785.96

H.S CODE

2941.90.1010

SMILES

O([C@@H]1[C@H](C[C@H]([C@@H](C=CC=CC[C@H](OC(C[C @H]([C@@H]1OC)O)=O)C)O)C)CC=O)[C@@H]1[C@@H]([C@@ H]([C@@H](O[C@@H]2C[C@@]([C@@H](O*)[C@@H](O2)C) (C)O)CO1)N(C)C)O

CLASSIFICATION

Antibacterial,

EXTRA NOTES

A macrolide antibiotic produced by Streptomyces kitasatoensis. The drug has antimicrobial activity against a wide spectrum of pathogens.

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE.

white to yellowish powder

MELTING POINT

 

BOILING POINT

 

DENSITY

 

SOLUBILITY IN WATER

 
SOLVENT SOLUBILITY  

VAPOR DENSITY

 

log P(octanol-water)

 

VAPOR PRESSURE

 

AUTOIGNITION TEMP

 
pH

 

REFRACTIVE INDEX

 

FLASH POINT

 

 

STABILITY AND REACTIVITY
STABILITY Stable under normal conditions.

INCOMPATIBLE MATERIALS

n/a

POLYMERIZATION

Has not been reported

NFPA RATINGS

Health hazard: 1, Flammability: 0, Physical hazards: 0

 

EXTERNAL LINKS & GENERAL DESCRIPTION

Wikipedia Linking

Google Scholar Search

Drug Information Portal (U.S. National Library of Medicine) - Kitasamycin

PubChem Compound Summary - Kitasamycin

Drug Bank - Kitasamycin

KEGG (Kyoto Encyclopedia of Genes and Genomes) -  Kitasamycin

http://www.ebi.ac.uk/ -  Kitasamycin

http://www.ncbi.nlm.nih.gov/ - Kitasamycin

http://www.biology-online.org/
Kitasamycin was developed by Japanese Kitasa Institute in 1960. The antibiotic was produced by Streptomycin kitasatoensis with the active compound of 16 carbon macrolide. The antibiotic has other names such as Selectomycin´╝î leucomycin, ayermicina, sineptin. This antibiotic was approved by Ministry of Agriculture in 2001 as the growth promoter additive in poultry and swine to control and prevent digestive and respiratory diseases. Pharmacology Characteristic: Belonging to the macrolide antibiotic, its antibacterial activity is similar to tylosin, erythromycin, spiramycin and oleandomycin. The mode of action is to inhibit the protein synthesis process. Its inhibition spectrum includes Mycoplasmas, Gram-positive bacteria, some Gram-negative bacteria, Leptospira, Rickettsia. It also inhibits most bacteria resistant to penicillin, oxytetracycline, chlortetracycline, erythromycin and chloramphenicol bacteria strains. It is a safe and high efficacy growth-promoting additive for swine and poultry.

http://aac.asm.org/
Biosynthesis of Kitasamycin(Leucomycin) by Leucine Analog-Resistant Mutants of
Streptomyces kitasatoensis

 

 

SALES SPECIFICATION

APPEARANCE

white to yellowish powder

IDENTIFICATION

passes test

ASSAY

90.0% - 100.0%

BIOLOGICAL POTENCY

450u/mg ~ 550u/mg

LOSS ON DRYING

10.0% max

HEAVY METALS

20ppm max

ARSENIC

5ppm max

 

TRANSPORT & REGULATORY INFORMATION

UN NO.

 

HAZARD SYMBOL

 

PACKING GROUP  

 

PACKING

 

 

PRICE INFORMATION