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http://www.cedars-sinai.edu/ Carmustine and lomustine are lipid soluble drugs: penetrate the nervous system ( treat central nervous system malignancies, optic and neurological complications were reported) • Used also for treating malignant lymphomas, melanomas and some GIT tumors • Myelosuppression is the dose-limiting toxicity • Cause nausea and vomiting • Long term use of carmustine may cause pulmonary toxicity |