LOMUSTINE

Synonyms. Lomustine; 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea; (Chloro-2-ethyl)-1-cyclohexyl- 3-nitrosourea; (Cloro-2-etil)-1-cicloesil-3-nitrosourea; 1-(2-Chloroethyl)-3-cyclohexylnitrosourea; Chloroethylcyclohexylnitrosourea; Cyclohexyl chloroethyl nitrosourea; N-(2-Chloroethyl)-N'- cyclohexyl- N-nitrosourea; Belustine; Cecenu; CCNU; CeeNU; CINU;

LOMUSTINE

Click for original image

 

PRODUCT IDENTIFICATION

CAS RN

13010-47-4

EINECS RN

235-859-2

FORMULA

 C9H16ClN3O2

MOLE WEIGHT

233.70

H.S CODE

 2924.29.9500

SMILES

 C1(NC(=O)N(CCCl)N=O)CCCCC1

CLASSIFICATION

Antineoplastic agent, Alkylating agent, Nitrosourea

EXTRA NOTES

 An alkylating agent of value against both hematologic malignancies and solid tumors. (MeSH)
Overall Carcinogenic Evaluation: Group 2A

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE.

white to yellow crystalline powder

MELTING POINT

88 ~ 90 C

BOILING POINT

 

DENSITY

 

SOLUBILITY IN WATER

111 mg/l

SOLVENT SOLUBILITY Freely soluble in chloroform. Soluble in ethanol, acetone and slightly soluble in acetonitrile, very slightly soluble in methanol.

VAPOR DENSITY

 

log P(octanol-water)

 2.365

VAPOR PRESSURE

 1.01E-05 mm Hg

AUTOIGNITION TEMP

  
pH

 

REFRACTIVE INDEX

1.548

FLASH POINT

 

 

STABILITY AND REACTIVITY
STABILITY Stable under normal conditions.

INCOMPATIBLE MATERIALS

Strong oxidizing agents, Strong bases, moisture

POLYMERIZATION

Has not been reported

NFPA RATINGS

Health: 2, Flammability:0, Reactivity: 0

 

EXTERNAL LINKS & GENERAL DESCRIPTION

Wikipedia Linking - Lomustine

Google Scholar Search - Lomustine

Drug Information Portal (U.S. National Library of Medicine) - Lomustine

PubChem Compound Summary - Lomustine

Drug Bank -  Lomustine

KEGG (Kyoto Encyclopedia of Genes and Genomes) - Lomustine

http://www.ebi.ac.uk/ - Lomustine

http://www.ncbi.nlm.nih.gov/ - Lomustine

http://toxnet.nlm.nih.gov/
Hazardous Substances Data Bank - Lomustine

http://www.cedars-sinai.edu/
Carmustine and lomustine are lipid soluble drugs: penetrate the nervous system ( treat central nervous system malignancies, optic and neurological complications were reported) • Used also for treating malignant lymphomas, melanomas and some GIT tumors • Myelosuppression is the dose-limiting toxicity • Cause nausea and vomiting • Long term use of carmustine may cause pulmonary toxicity

 

SALES SPECIFICATION

APPEARANCE

white to yellow crystalline powder

IDENTIFICATION

positive (Test A,B)

CONTENT

98.5% ~ 101.5%

LOSS ON DRYING

1.0% max

HEAVY METALS

20ppm max

RELATED SUBSTANCES

Total impurities:1.0% max, single impurity:0.5% max

MELTING POINT

88 ~ 90 C

 

TRANSPORT & REGULATORY INFORMATION

UN NO.

2811

HAZARD CLASS

 6.1
PACKING GROUP III

 

SAFETY INFORMATION

HAZARD OVERVIEW

Toxic if swallowed. May cause cancer. OSHA Hazards: Carcinogen, Target Organ Effect, Toxic by ingestion. Target Organs:Bone marrow

GHS

  

SIGNAL WORD

Danger

PICTOGRAMS

HAZARD STATEMENTS

H301-H350

P STATEMENTS

P201-P301 + P310-P308 + P313

EC DIRECTIVES

 

HAZARD CODES

T

RISK PHRASES

45-25

SAFETY PHRASES

 53-45

 

PACKING

Preserve in light-resistant and well-closed containers